Periodontal disease
Periodontal disease | |
---|---|
Other names | Gum disease, pyorrhea, periodontitis |
Usual onset | Getting gingivitis[3] |
Causes | Bacteria related plaque build up[1] |
Risk factors | Smoking,[4] diabetes, HIV/AIDS, certain medications[1] |
Diagnostic method | Dental examination, X-rays[1] |
Treatment | Good oral hygiene, regular professional cleaning[5] |
Frequency | 538 million (2015)[6] |
Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth.[5] In its early stage, called gingivitis, the gums become swollen and red and may bleed.[5] It is considered the main cause of tooth loss for adults worldwide.[7][8] In its more serious form, called periodontitis, the gums can pull away from the tooth, bone can be lost, and the teeth may loosen or fall out.[5] Halitosis (bad breath) may also occur.[1]
Periodontal disease is generally due to bacteria in the mouth infecting the tissue around the teeth.
Treatment involves good
Signs and symptoms
In the early stages, periodontitis has very few symptoms, and in many individuals the disease has progressed significantly before they seek treatment.
Symptoms may include:
- Redness or bleeding of gums while brushing teeth, using dental floss or biting into hard food (e.g., apples) (though this may also occur in gingivitis, where there is no attachment loss gum disease)
- Gum swelling that recurs
- Spitting out blood after brushing teeth
- Halitosis, or bad breath, and a persistent metallic taste in the mouth
- Gingival recession, resulting in apparent lengthening of teeth (this may also be caused by heavy-handed brushing or with a stiff toothbrush)
- Deep pockets between the teeth and the gums (collagenases)
- Loose teeth, in the later stages (though this may occur for other reasons, as well)
Gingival inflammation and bone destruction are largely painless. Hence, people may wrongly assume painless bleeding after teeth cleaning is insignificant, although this may be a symptom of progressing periodontitis in that person.
Associated conditions
Periodontitis has been linked to increased
Diabetes and periodontal disease
A positive correlation between raised levels of glucose within the blood and the onset or progression of periodontal disease has been shown in the current literature.
Data has also shown that there is a significant increase in the incidence or progression of periodontitis in patients with uncontrolled diabetes compared to those who do not have diabetes or have well-controlled diabetes. In uncontrolled diabetes, the formation of reactive oxygen species can damage cells such as those in the connective tissue of the periodontal ligament, resulting in cell necrosis or apoptosis. Furthermore, individuals with uncontrolled diabetes mellitus who have frequent exposure to periodontal pathogens have a greater immune response to these bacteria. This can subsequently cause and/or accelerate periodontal tissue destruction leading to periodontal disease.[36]
Oral cancer and periodontal disease
Current literature suggests a link between periodontal disease and oral cancer. Studies have confirmed an increase in systemic inflammation markers such as C-Reactive Protein and Interleukin-6 to be found in patients with advanced periodontal disease. The link between systemic inflammation and oral cancer has also been well established.
Both periodontal disease and cancer risk are associated with genetic susceptibility and it is possible that there is a positive association by a shared genetic susceptibility in the two diseases.
Due to the low incidence rate of oral cancer, studies have not been able to conduct quality studies to prove the association between the two, however future larger studies may aid in the identification of individuals at a higher risk.[37]
Systemic implications
Periodontal disease (PD) can be described as an inflammatory condition affecting the supporting structures of the teeth. Studies have shown that PD is associated with higher levels of systemic inflammatory markers such as Interleukin-6 (IL-6), C-Reactive Protein (CRP) and Tumor Necrosis Factor (TNF). To compare, elevated levels of these inflammatory markers are also associated with cardiovascular disease and cerebrovascular events such as ischemic strokes.[38]
The presence of a wide spectrum inflammatory oral diseases can increase the risk of an episode of stroke in an acute or chronic phase. Inflammatory markers, CRP, IL-6 are known risk factors of stroke. Both inflammatory markers are also biomarkers of PD and found to be an increased level after daily activities, such as mastication or toothbrushing, are performed. Bacteria from the periodontal pockets will enter the bloodstream during these activities and the current literature suggests that this may be a possible triggering of the aggravation of the stroke process.[39]
Other mechanisms have been suggested, PD is a known chronic infection. It can aid in the promotion of atherosclerosis by the deposition of cholesterol, cholesterol esters and calcium within the subendothelial layer of vessel walls.[40] Atherosclerotic plaque that is unstable may rupture and release debris and thrombi that may travel to different parts of the circulatory system causing embolization and therefore, an ischemic stroke. Therefore, PD has been suggested as an independent risk factor for stroke.
A variety of cardiovascular diseases can also be associated with periodontal disease. Patients with higher levels of inflammatory markers such as TNF, IL-1, IL-6 and IL-8 can lead to progression of atherosclerosis and the development and perpetuation of atrial fibrillation,[41] as it is associated with platelet and coagulation cascade activations, leading to thrombosis and thrombotic complications.
Experimental animal studies have shown a link between periodontal disease, oxidative stress and cardiac stress. Oxidative stress favours the development and progression of heart failure as it causes cellular dysfunction, oxidation of proteins and lipids, and damage to the deoxyribonucleic acid (DNA), stimulating fibroblast proliferation and metalloproteinases activation favouring cardiac remodelling.[42]
During SARS Covid 19 pandemic, Periodontitis was significantly associated with a higher risk of complications from COVID‐19, including ICU admission, need for assisted ventilation and death and increased blood levels of markers such as D‐dimer, WBC and CRP which are linked with worse disease outcome. [43]
Clinical significance
This section may need to be rewritten to comply with Wikipedia's quality standards, as it focuses on a single aspect of the disease while ignoring other clinical consequences.. (April 2024) |
Inadequate nutrition and periodontal disease
Periodontal disease is multifactorial, and nutrition can significantly affect its prognosis. Studies have shown that a healthy and well-balanced diet is crucial to maintaining periodontal health. [11] Nutritional deficiencies can lead to oral manifestations such as those in scurvy and rickets disease. Different vitamins will play a different role in periodontal health:
- Vitamin C: Deficiencies may lead to gingival inflammation and bleeding, subsequently advancing periodontal disease
- Vitamin D: Deficiencies may lead to delayed post-surgical healing
- Vitamin E: Deficiencies may lead to impaired gingival wound healing
- Vitamin K: Deficiencies may lead to gingival bleeding
Nutritional supplements of vitamins have also been shown to positively affect healing after periodontal surgery and many of these vitamins can be found in a variety of food that we eat within a regular healthy diet. [11] Therefore, vitamin intakes (particularly vitamin C) and dietary supplements not only play a role in improving periodontal health, but also influence the rate of bone formation and periodontal regeneration. However, studies supporting the correlation between nutrition and periodontal health are limited, and more long-term research is required to confirm this. [44]
Causes
Periodontitis is an inflammation of the periodontium, i.e., the tissues that support the teeth. The periodontium consists of four tissues:
- gingiva, or gum tissue,
- cementum, or outer layer of the roots of teeth,
- alveolar bone, or the bony sockets into which the teeth are anchored, and
- periodontal ligaments (PDLs), which are the connective tissuefibers that run between the cementum and the alveolar bone.
The primary cause of gingivitis is poor or ineffective
In some people, gingivitis progresses to periodontitis – with the destruction of the
Smoking is another factor that increases the occurrence of periodontitis, directly or indirectly,[52][53][54] and may interfere with or adversely affect its treatment.[55][56][57] It is arguably the most important environmental risk factor for periodontitis. Research has shown that smokers have more bone loss, attachment loss and tooth loss compared to non-smokers.[58] This is likely due to several effects of smoking on the immune response including decreased wound healing, suppression of antibody production, and the reduction of phagocytosis by neutrophils[58]
Ehlers–Danlos syndrome and Papillon–Lefèvre syndrome (also known as palmoplantar keratoderma) are also risk factors for periodontitis.
If left undisturbed, microbial plaque calcifies to form
Periodontitis may be associated with higher stress.[59] Periodontitis occurs more often in people in the lower classes than people in the upper classes.[60]
Genetics appear to play a role in determining the risk for periodontitis. It is believed genetics could explain why some people with good plaque control have advanced periodontitis, whilst some others with poor oral hygiene are free from the disease. Genetic factors which could modify the risk of a person developing periodontitis include:
- Defects of phagocytosis: person may have hypo-responsive phagocytes.
- Hyper-production of interleukins, prostaglandins and cytokines, resulting in an exaggerated immune response.
- Interleukin 1 (IL-1) gene polymorphism: people with this polymorphism produce more IL-1, and subsequently are more at risk of developing chronic periodontitis.[58]
Diabetes appears to exacerbate the onset, progression, and severity of periodontitis.
Mechanism
As dental plaque or biofilm accumulates on the teeth near and below the gums there is some
Plaque may be soft and uncalcified, hard and calcified, or both; for plaques that are on teeth the calcium comes from saliva; for plaques below the gumline, it comes from blood via oozing of inflamed gums.[64]
The damage to teeth and gums comes from the immune system as it attempts to destroy the microbes that are disrupting the normal symbiosis between the oral tissues and the oral microbe community. As in other tissues,
Classification
There were several attempts to introduce an agreed-upon classification system for periodontal diseases: in 1989, 1993, 1999,[65] and 2017.
1999 classification
The 1999 classification system for periodontal diseases and conditions listed seven major categories of periodontal diseases,[65] of which 2–6 are termed destructive periodontal disease, because the damage is essentially irreversible. The seven categories are as follows:
- Gingivitis
- Chronic periodontitis
- Aggressive periodontitis
- Periodontitis as a manifestation of systemic disease
- Necrotizing ulcerative gingivitis/periodontitis
- Abscesses of the periodontium
- Combined periodontic-endodontic lesions
Moreover, terminology expressing both the extent and severity of periodontal diseases are appended to the terms above to denote the specific diagnosis of a particular person or group of people.
Severity
The "severity" of disease refers to the amount of
- Slight: 1–2 mm (0.039–0.079 in) of attachment loss
- Moderate: 3–4 mm (0.12–0.16 in) of attachment loss
- Severe: ≥ 5 mm (0.20 in) of attachment loss
Extent
The "extent" of disease refers to the proportion of the dentition affected by the disease in terms of percentage of sites. Sites are defined as the positions at which probing measurements are taken around each tooth and, generally, six probing sites around each tooth are recorded, as follows:
- Mesiobuccal
- Mid-buccal
- Distobuccal
- Mesiolingual
- Mid-lingual
- Distolingual
If up to 30% of sites in the mouth are affected, the manifestation is classified as "localized"; for more than 30%, the term "generalized" is used.
2017 classification
The 2017 classification of periodontal diseases is as follows:[67][68][69]
Periodontal health, gingival disease and conditions
- Periodontal health and gingival health
- Clinical gingival health on an intact periodontium
- Clinical gingival health on an intact periodontium
- Stable periodontitis
- Non periodontitis person
- Gingivitis - Dental biofilm induced
- Associated with the dental biofilm alone
- Mediated by systemic and local risk factors
- Drug induced gingival enlargement.
- Gingival diseases - Non dental biofilm induced
- Genetic/developmental disorders
- Specific infections
- Inflammatory and immune conditions
- Reactive processes
- Neoplasms
- Endocrine, nutritional and metabolic
- Traumatic lesions
- Gingival pigmentation.
Periodontitis
- Necrotizing periodontal diseases
- Necrotizing Gingivitis
- Necrotizing periodontitis
- Necrotizing stomatitis
- Periodontitis as a manifestation of systemic disease
- Periodontitis
Other conditions affecting the periodontium
(Periodontal Manifestations of Systemic Diseases and Developmental and Acquired Conditions)
- Systemic disease of conditions affecting the periodontalsupport tissues
- Other Periodontal Conditions
- Periodontal abscesses
- Endodontic- periodontal lesions
- Mucogingival deformities and conditions
- Gingival Phenotype
- Gingival/Soft Tissue Recession
- Lack of Gingiva
- Decreased Vestibular Depth
- Aberrant Frenum/muscle position
- Gingival Excess
- Abnormal Color
- Condition of the exposed root surface
- Traumatic occlusal forces
- Primary Occlusal Trauma
- Secondary Occlusal Trauma
- Tooth and prosthesis related factors
- Localized tooth-related factors
- Localized dental prostheses-related factors
Peri-implant diseases and conditions
- Peri-implant health
- Peri-implant mucositis
- Peri-implantitis
- Peri-implant soft and hard tissue deficiencies
Staging
The goals of staging periodontitis is to classify the severity of damage and assess specific factors that may affect management.[69]
According to the 2017 classification, periodontitis is divided into four stages; after considering a few factors such as:
- Amount and percentage bone loss radiographically
- Clinical attachment loss, probing depth
- Presence of furcation
- Vertical bony defects
- History of tooth loss related to periodontitis
- Tooth hypermobility due to secondary occlusal trauma[69]
Grading
According to the 2017 classification, the grading system for periodontitis consists of three grades:[70]
- Grade A: Slow progression of disease; no evidence of bone loss over last five years
- Grade B: Moderate progression; < 2mm of bone loss over last five years
- Grade C: Rapid progression or future progression at high risk; ≥ 2mm bone loss over five years
Risk factors affecting which grade a person is classified into include:[70]
- Smoking
- Diabetes
Periodontal probing
Dentists and dental hygienists measure periodontal disease using a device called a periodontal probe. This thin "measuring stick" is gently placed into the space between the gums and the teeth, and slipped below the gumline. If the probe can slip more than 3 mm (0.12 in) below the gumline, the person is said to have a gingival pocket if no migration of the epithelial attachment has occurred or a periodontal pocket if apical migration has occurred. This is somewhat of a misnomer, as any depth is, in essence, a pocket, which in turn is defined by its depth, i.e., a 2-mm pocket or a 6-mm pocket. However, pockets are generally accepted as self-cleansable (at home, by the person, with a toothbrush) if they are 3 mm or less in depth. This is important because if a pocket is deeper than 3 mm around the tooth, at-home care will not be sufficient to cleanse the pocket, and professional care should be sought. When the pocket depths reach 6 to 7 mm (0.24 to 0.28 in) in depth, the hand instruments and ultrasonic scalers used by the dental professionals may not reach deeply enough into the pocket to clean out the microbial plaque that causes gingival inflammation. In such a situation, the bone or the gums around that tooth should be surgically altered or it will always have inflammation which will likely result in more bone loss around that tooth. An additional way to stop the inflammation would be for the person to receive subgingival antibiotics (such as minocycline) or undergo some form of gingival surgery to access the depths of the pockets and perhaps even change the pocket depths so they become 3 mm or less in depth and can once again be properly cleaned by the person at home with his or her toothbrush.
Prevention
Daily oral hygiene measures to prevent periodontal disease include:
- Brushing properly on a regular basis (at least twice daily), with the person attempting to direct the toothbrush bristles underneath the gumline, helps disrupt the bacterial-mycotic growth and formation of subgingival plaque.[citation needed]
- Flossing daily and using interdental brushes (if the space between teeth is large enough), as well as cleaning behind the last tooth, the third molar, in each quarter.[citation needed]
- Using an antiseptic Chlorhexidine gluconate-based mouthwash in combination with careful oral hygiene may cure gingivitis, although they cannot reverse any attachment loss due to periodontitis.[citation needed]
- Regular dental check-ups and professional teeth cleaning as required: Dental check-ups serve to monitor the person's oral hygiene methods and levels of attachment around teeth, identify any early signs of periodontitis, and monitor response to treatment.
Typically, dental hygienists (or dentists) use special instruments to clean (debride) teeth below the gumline and disrupt any plaque growing below the gumline. This is a standard treatment to prevent any further progress of established periodontitis. Studies show that after such a professional cleaning (periodontal debridement), microbial plaque tends to grow back to precleaning levels after about three to four months. Nonetheless, the continued stabilization of a person's periodontal state depends largely, if not primarily, on the person's oral hygiene at home, as well as on the go. Without daily oral hygiene, periodontal disease will not be overcome, especially if the person has a history of extensive periodontal disease.[citation needed]
Management
The cornerstone of successful periodontal treatment starts with establishing excellent
Initial therapy
Removal of microbial plaque and calculus is necessary to establish periodontal health. The first step in the treatment of periodontitis involves nonsurgical cleaning below the gum line with a procedure called "root surface instrumentation" or "RSI", this causes a mechanical disturbance to the bacterial biofilm below the gumline.[58] This procedure involves the use of specialized curettes to mechanically remove plaque and calculus from below the gumline, and may require multiple visits and local anesthesia to adequately complete. In addition to initial RSI, it may also be necessary to adjust the occlusion (bite) to prevent excessive force on teeth that have reduced bone support. Also, it may be necessary to complete any other dental needs, such as replacement of rough, plaque-retentive restorations, closure of open contacts between teeth, and any other requirements diagnosed at the initial evaluation. It is important to note that RSI is different to scaling and root planing: RSI only removes the calculus, while scaling and root planing removes the calculus as well as underlying softened dentine, which leaves behind a smooth and glassy surface, which is not a requisite for periodontal healing. Therefore, RSI is now advocated over root planing.[58]
Reevaluation
Nonsurgical scaling and root planing are usually successful if the periodontal pockets are shallower than 4–5 mm (0.16–0.20 in).[71][72][73] The dentist or hygienist must perform a re-evaluation four to six weeks after the initial scaling and root planing, to determine if the person's oral hygiene has improved and inflammation has regressed. Probing should be avoided then, and an analysis by gingival index should determine the presence or absence of inflammation. The monthly reevaluation of periodontal therapy should involve periodontal charting as a better indication of the success of treatment, and to see if other courses of treatment can be identified. Pocket depths of greater than 5–6 mm (0.20–0.24 in) which remain after initial therapy, with bleeding upon probing, indicate continued active disease and will very likely lead to further bone loss over time. This is especially true in molar tooth sites where furcations (areas between the roots) have been exposed.
Surgery
If nonsurgical therapy is found to have been unsuccessful in managing signs of disease activity, periodontal surgery may be needed to stop progressive bone loss and regenerate lost bone where possible. Many surgical approaches are used in the treatment of advanced periodontitis, including open flap debridement and osseous surgery, as well as guided tissue regeneration and bone grafting. The goal of periodontal surgery is access for definitive calculus removal and surgical management of bony irregularities which have resulted from the disease process to reduce pockets as much as possible. Long-term studies have shown, in moderate to advanced periodontitis, surgically treated cases often have less further breakdown over time and, when coupled with a regular post-treatment maintenance regimen, are successful in nearly halting tooth loss in nearly 85% of diagnosed people.[74][75]
Local drug delivery
Local drug deliveries in periodontology has gained acceptance and popularity compared to systemic drugs due to decreased risk in development of resistant flora and other side effects.[76] A meta analysis of local tetracycline found improvement.[77] Local application of statin may be useful.[78]
Systemic drug delivery
Systemic drug delivery in conjunction with non-surgical therapy may be used as a means to reduce the percentage of the bacterial plaque load in the mouth. Many different antibiotics and also combinations of them have been tested; however, there is yet very low-certainty evidence of any significant difference in the short and long term compared to non-surgical therapy alone. It may be beneficial to limit the use of systemic drugs, since bacteria can develop antimicrobial resistance and some specific antibiotics might induce temporary mild adverse effects, such as nausea, diarrhoea and gastrointestinal disturbances.[79]
Adjunctive systemic antimicrobial treatment
There is currently low-quality evidence suggesting if adjunctive systemic antimicrobials are beneficial for the non-surgical treatment of periodontitis.[80] It is not sure whether some antibiotics are better than others when used alongside scaling and root planing).
Maintenance
Once successful periodontal treatment has been completed, with or without surgery, an ongoing regimen of "periodontal maintenance" is required. This involves regular checkups and detailed cleanings every three months to prevent repopulation of periodontitis-causing microorganisms, and to closely monitor affected teeth so early treatment can be rendered if the disease recurs. Usually, periodontal disease exists due to poor plaque control resulting from inappropriate brushing. Therefore, if the brushing techniques are not modified, a periodontal recurrence is probable.
Other
Most alternative "at-home" gum disease treatments involve injecting antimicrobial solutions, such as hydrogen peroxide, into periodontal pockets via slender applicators or oral irrigators. This process disrupts anaerobic micro-organism colonies and is effective at reducing infections and inflammation when used daily. A number of other products, functionally equivalent to hydrogen peroxide, are commercially available, but at substantially higher cost. However, such treatments do not address calculus formations, and so are short-lived, as anaerobic microbial colonies quickly regenerate in and around calculus.
Doxycycline may be given alongside the primary therapy of scaling (see § initial therapy).[81] Doxycycline has been shown to improve indicators of disease progression (namely probing depth and attachment level).[81] Its mechanism of action involves inhibition of matrix metalloproteinases (such as collagenase), which degrade the teeth's supporting tissues (periodontium) under inflammatory conditions.[81] To avoid killing beneficial oral microbes, only small doses of doxycycline (20 mg) are used.[81]
Phage therapy may be a new therapeutic alternative.[82]
Prognosis
If people have 7-mm or deeper pockets around their teeth, as measured by a periodontal probe, then they would likely risk eventual tooth loss over the years.[citation needed] If this periodontal condition is not identified and people remain unaware of the progressive nature of the disease, then years later, they may be surprised that some teeth will gradually become loose and may need to be extracted, sometimes due to a severe infection or even pain.[citation needed]
According to the Sri Lankan tea laborer study, in the absence of any oral hygiene activity, approximately 10% will experience severe periodontal disease with rapid loss of attachment (>2 mm/year). About 80% will experience moderate loss (1–2 mm/year) and the remaining 10% will not experience any loss.[83][84]
Epidemiology
no data <3.5 3.5–4 4–4.5 4.5–5 5–5.5 5.5–6 | 6–6.5 6.5–7 7–7.5 7.5–8 8–8.5 >8.5 |
Periodontitis is very common, and is widely regarded as the second most common dental disease worldwide, after
Chronic periodontitis affects about 750 million people or about 10.8% of the world population as of 2010.[86]
Like other conditions intimately related to access to hygiene and basic medical monitoring and care, periodontitis tends to be more common in economically disadvantaged populations or regions. Its occurrence decreases with a higher standard of living. In Israeli populations, individuals of Yemenite, North-African, South Asian, or Mediterranean origin have higher prevalence of periodontal disease than individuals from European descent.[87] Periodontitis is frequently reported to be socially patterned, i.e. people from the lower end of the socioeconomic scale are affected more often than people from the upper end of the socioeconomic scale.[60]
History
An ancient hominid from 3 million years ago had gum disease.
Society and culture
Etymology
The word "periodontitis" (
Economics
It is estimated that lost productivity due to severe periodontitis costs the global economy about US$54 billion each year.[93]
Other animals
Periodontal disease is the most common disease found in dogs and affects more than 80% of dogs aged three years or older. Its prevalence in dogs increases with age, but decreases with increasing body weight; i.e., toy and miniature breeds are more severely affected. Recent research undertaken at the
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External links
- Canadian Academy of Periodontology — What is periodontitis?
- Periodontal disease and braces. Orthodontics Australia.