Essential hypertension
Essential hypertension | |
---|---|
Other names | Primary hypertension |
Specialty | Cardiology |
Essential hypertension (also called primary hypertension, or idiopathic hypertension) is a form of
Classification
Blood pressure is classified as normal blood pressure,
Classification | Systolic pressure | Diastolic pressure | ||
---|---|---|---|---|
mmHg
|
kPa (kN/m2) | mmHg | kPa (kN/m2) | |
Normal | 90–119 | 12–15.9 | 60–79 | 8.0–10.5 |
Prehypertension | 120–139 | 16.1–18.5 | 80–89 | 10.8–11.9 |
Stage 1 | 140–159 | 18.7–21.2 | 90–99 | 12.0–13.2 |
Stage 2 | ≥160 | ≥21.3 | ≥100 | ≥13.3 |
Isolated systolic
hypertension |
≥140 | ≥18.7 | <90 | <12.0 |
Source: American Heart Association (2003).[6] |
Resistant hypertension is defined as the failure to reduce blood pressure to normal levels following an adequate trial of three antihypertensive medications.[6] Guidelines for treating resistant hypertension have been published in the UK, and US.[7]
Risk factors
The etiology of hypertension differs widely amongst individuals within a large population.[8] While essential hypertension has no identifiable cause, several risk factors have been identified.
Genetics
Having a personal family history of hypertension increases the likelihood that an individual develops it.
Race
In the United States, essential hypertension is four times more common in black than white people, accelerates more rapidly and is often more severe with higher mortality in black patients.There are numerous racial inequities that contribute to black individuals having higher prevalence of essential hypertension than white people. These racial disparity-related risk factors are less conspicuous. Discrimination may have both a direct and indirect effect on hypertension. Chronic stress, like that caused by discrimination, has been linked to a number of health problems. Access to social, financial, and educational resources that can enhance one's health is unequally impacted by racial prejudice. Numerous studies have demonstrated the connection between feeling discriminated against and having elevated blood pressure. In comparison to participants who reported low levels of lifetime discrimination, a study from the Jackson Heart Study indicated that those people who reported high or medium levels of prejudice were more likely to acquire hypertension. Racial inequities are rarely acknowledged as significant risk factors in the healthcare industry.[13][14][15][9][16][17][18]
Diet
An unhealthy diet, which includes excessive consumption of unhealthy food, is a recognized risk factor for hypertension. A balanced diet is recommended for both its prevention and control.[19] Dietary sodium intake also contributes to blood pressure. Approximately one third of the essential hypertensive population is responsive to sodium intake.[20][21] When sodium intake exceeds the capacity of the body to excrete it through the kidneys, blood volume will expand due to movement of fluids by osmosis into the blood vessels. This causes the arterial pressure to rise as the cardiac output will increase. Local autoregulatory mechanisms counteract this by increasing the vascular resistance to blood flow in order to maintain normal pressure in the capillary blood vessels . As arterial pressure increases in response to high sodium chloride intake, urinary sodium excretion increases but this higher excretion of salt is maintained at the expense of increased arterial blood pressure.[9] The increased sodium ion concentration stimulates ADH and thirst mechanisms, leading to increased reabsorption of water in the kidneys, a concentrated urine, and thirst with a higher intake of water.
Aging
Hypertension can also be age-related when associated with a western diet and lifestyle, and if this is the case, it is likely to be multifactorial.[22] One possible mechanism involves a reduction in vascular compliance due to the stiffening of the arteries. This can build up due to isolated systolic hypertension with a widened pulse pressure. A decrease in glomerular filtration rate is related to aging and this results in decreasing efficiency of sodium excretion. The developing of certain diseases such as renal microvascular disease and capillary rarefaction may relate to this decrease in efficiency of sodium excretion. There is experimental evidence that suggests that renal microvascular disease is an important mechanism for inducing salt-sensitive hypertension.[23]
Obesity
Obesity can increase the risk of hypertension to fivefold as compared with normal weight, and up to two-thirds of hypertension cases can be attributed to excess weight.[24] More than 85% of cases occur in those with a Body mass index (BMI) greater than 25.[24] A definitive link between obesity and hypertension has been found using animal and clinical studies; from these it has been realized that many mechanisms are potential causes of obesity-induced hypertension. These mechanisms include the activation of the sympathetic nervous system as well as the activation of the renin–angiotensin–aldosterone system.[25]
Alcohol
Excessive alcohol consumption can increase blood pressure over time. Alcohol also contains a high density of calories and may contribute to obesity.[26]
Renin
Diabetes
Smoking
Smoking directly causes a temporary increase in blood pressure through activation of the
Vitamin deficiency
It has been suggested that
Also, some authorities claim that potassium might both prevent and treat hypertension.[32]
Lack of exercise
Regular physical exercise reduces blood pressure. The UK National Health Service advises 150 minutes (2 hours and 30 minutes) of moderate-intensity aerobic activity per week to help prevent hypertension.[26]
Pathophysiology
What is known is that
- An overactive Renin–angiotensin system leads to vasoconstriction and retention of sodium and water. The increase in blood volume leads to hypertension.
- An overactive sympathetic nervous system, leading to increased stress responses.
It is also known that hypertension is highly heritable and
[37]Essential hypertension can lead to impaired white matter of the brain, which is accompanied by specific cognitive impairment.[38]
Diagnosis
For most patients, health care providers diagnose high blood pressure when blood pressure readings are consistently 140/90 mmHg or above. A blood pressure test can be done in a health care provider's office or clinic. To track blood pressure readings over a period of time, the health care provider may ask the patient to come into the office on different days and at different times. The health care provider also may ask the patient to check readings at home or at other locations that have blood pressure equipment and to keep a written log of results. The health care provider usually takes 2–3 readings at several medical appointments to diagnose high blood pressure.[39] Using the results of the blood pressure test, the health care provider will diagnose prehypertension or high blood pressure if:
- For an adult, systolic or diastolic readings are consistently higher than 120/80 mmHg.
- A child's blood pressure numbers are outside average numbers for children of the same age, gender, and height.[39]
Once the health care provider determines the severity, he or she may order additional tests to determine if the blood pressure is due to other conditions, medications, or if there is primary high blood pressure. Health care providers can use this information to develop a treatment plan.[39]
History
Prior to the work of Australian cardiovascular physiologist Paul Korner, in the 1940s, little was known about essential hypertension.[40]
See also
References
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- ^ Williams B, et al. (British Hypertension Society) (2006). Sutters M (ed.). "Hypertension Etiology & Classification – Secondary Hypertension". Armenian Medical Network. Retrieved December 2, 2007.
- ^ Wazlowski S (September 1, 2020). "Study: Racial discrimination can increase hypertension in blacks". The Nation's Health. 50 (7): 5.
- ^ Hedgepeth C (September 21, 2020). "Discrimination, high blood pressure, and health disparities in African Americans". Harvard Health.
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- ^ http://www.jstage.jst.go.jp/article/jphs/100/5/370/_pdf[permanent dead link] A Missing Link Between a High Salt Intake and Blood Pressure Increase: Makoto Katori and Masataka Majima, Department of Pharmacology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan February 8, 2006
- ^ http://hyper.ahajournals.org/content/27/3/481.full Salt Sensitivity of Blood Pressure in Humans Myron H. Weinberger Indiana University School of Medicine, Hypertension 1996 doi:10.1161/01.HYP.27.3.481
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- ^ a b "Prevention". nhs.uk. October 23, 2017. Retrieved April 11, 2018.
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- ^ Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health (2010), "Cardiovascular Diseases", How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General, Centers for Disease Control and Prevention (US), retrieved February 8, 2024
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- ^ Klabunde RE (2007). "Cardiovascular Physiology Concepts – Mean Arterial Pressure". Retrieved September 29, 2008.
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- ^ Bello Inumidun Taofik (2017). diagnosis impact of hypertension
- ^ Pervichko E, Ostroumova T, Darevskaya M, Perepelova E, Perepelov V, Vartanov A, et al. (2018). "A psychophysiological study ofcognitive disorders in naivemiddle-age patients withuncomplicated essential hypertensionand white matter lesions". European Psychiatry. 48S: 114.
- ^ a b c "Diagnosis of High Blood Pressure - NHLBI, NIH". National Institutes of Health. March 24, 2022. This article incorporates text from this source, which is in the public domain.
- ^ "World authority on blood pressure: Paul Korner". Sydney Morning Herald. Fairfax Media. November 30, 2012.