Goitrogen
Goitrogens are substances that disrupt the production of
goiter.[1]
Goitrogenic drugs and chemicals
Chemicals that have been shown to have goitrogenic effects include:
- Sulfadimethoxine (Albon),[2] propylthiouracil,[3] potassium perchlorate,[4] and iopanoic acid.[5]
- Some oxazolidines such as goitrin.[6]
- Ions such as thyrotropin (by reduced negative feedback), which then stimulates the gland.[citation needed]
- thyroxine to triiodothyronine; also interferes with thyroid hormone action.[citation needed]
- Lithium inhibits thyroid hormone release.[citation needed]
- rifampin induce metabolic degradation of triiodothyronine (T3) and thyroxine (T4).[citation needed]
Goitrogenic foods
Foods which have been demonstrated to have goitrogenic effects include
vegetables in the genus Brassica (such as broccoli and cabbage),[9][page needed] and other cruciferous vegetables.[10] In places where iodine deficiency exists in tandem with millet being a major component of the diet, millet consumption can contribute to thyroid enlargement which is the start of endemic goiter.[11]
See also
References
- ISBN 9780199234875.
- ^ Blackwell T, Werdin R, Eisenmenger M, FitzSimmons M (March 1989). "Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation". Journal of the American Veterinary Medical Association. 194 (4): 519–523.
- PMID 19843064.
- PMID 11477312.
- PMID 24895606.
- PMID 9055870.
- ^ PMID 16704348.
- PMID 14757960.
- ISBN 978-1-4160-2973-1.
- PMID 1696490.
- PMID 2921306.