HLA-B39

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Further information: HLA-serotype tutorial
Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B39
Alleles B*3901, 3902, 3903, . .
Structure (See HLA-B)
Shared data
Locus
chr.6 6p21.31

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.[1]

B39 is a split antigen of the broad antigen B16, and is a sister type of B38. B39 is most commonly found on the west pacific rim, in Japan and highest frequency in the new world. In Europe it is found in Scandinavia and Northern Russia.

Serotype

Serotypes B39, B16, and B38 recognition of the
HLA B*39 gene products[2]
B*39 B39 B16 B38 Sample
allele % % % size (N)
*3901 95 476
*3902 87 96
*3903 77 20
*3905 82 245
*3906 94 508
*3908 48 57
*3909 97 13
*3910 82 127
*3911 69 16
Alleles link-out to IMGT/HLA Databease at EBI

The serology for the most common B39 alleles, B*3901 and B*3906 is good, but some allele products are not well detected. Given the differential involvement of these alleles in disease testing should involve high resolution typing.

HLA B*3906 frequencies
freq
ref. Population (%)
[3] Venezuela Perja Mountain Bari 23.9
Mexico Mixtec Oaxaca 8.8
USA Arizona Pima 7.3
USA South Texas Hispanics 5.6
Mexico Zaptotec Oaxaca 4.5
New Mexico Canoncito Navajo 3.7
Oman 2.5
PNG Wanigela 2.3
Tunisia Tunis 2.3
North American Natives 1.9
USA Hispanic 1.7
Brazil Belo Horizonte 1.6
South Dakota Lakota Sioux 1.5
Cuban White 1.4
Azores S. Maria & S. Miguel 1.3
Australia New South Wales 1.1
Finland 1.1
Portugal North 1.1
Portugal Centre 1.0
Spain Eastern Andalusia Gipsy 1.0
Brazil Terena 0.9
Ireland Northern 0.9
Azores Terceira Island 0.8
USA Caucasian pop2 0.8
Brazil 0.7
USA Philadelphia Caucasians 0.7
India Andhra Pradesh Golla 0.5
Thailand 0.4

Alleles

HLA B*3901 frequencies
freq
ref. Population (%)
[3] Taiwan Saisiat 54.9
[3] Taiwan Tsou 24.5
[3] South Dakota Lakota Sioux 22.5
[3] Taiwan Taroko 21.8
[3] Taiwan Atayal 19.8
[3] PNG Wanigela 16.7
[3] Japan Ainu Hokkaido 16.0
[3] Taiwan Bunun 14.9
[3] New Mexico Canoncito Navajo 14.6
[3] Taiwan Thao 13.3
[3] Taiwan Rukai 13.0
[3] Taiwan Ami 10.2
[3] USA Hawaii Okinawa 7.7
[3] Papua New Guinea Wosera 7.0
[3] Papua New Guinea Madang 6.4
[3] Mexico Mixtec Oaxaca 5.9
[3] Taiwan Puyuma 5.0
[3] Taiwan Paiwan 4.9
[3] New Caledonia 4.8
[3] Japan Central 4.4
[3] American Samoa 4.0
[3] USA North American Natives 4.0
[3] Taiwan Hakka 3.6
[3] Indig. Australian Cape York Peninsula 3.5
[3] Japan (5) 3.5
[3] Philippines Ivatan 3.0
[3] Brazil 2.9
[3] China Guangxi Maonan 2.8
[3] Georgia Tbilisi Georgians 2.8
[3] China Yunnan Nu 2.6
[3] Thailand 2.5
[3] Azores Terceira Island 2.4
[3] Singapore Chinese 2.4
[3] Romanian 2.3
[3] China Yunnan Lisu 2.2
[3] Indig. Australian Yuendumu 2.1
[3] China Guangzhou 2.0
[3] Croatia 2.0
[3] France South East 1.9
[3] Georgia Svaneti Svans 1.9
[3] PNG Karimui Plateau 1.9
[3] Azores Central Islands 1.8
[3] Spain Eastern Andalusia 1.8
[3] Uganda Kampala 1.6
[3] Mexico Zaptotec Oaxaca 1.5
[3] Singapore Thai 1.5
[3] China Guangzhou Han 1.4
[3] China Qinghai Hui 1.4
[3] Czech Republic 1.4
[3] Madeira 1.4
[3] Indig. Australian Kimberly 1.3
[3] Finland 1.1

Disease

B39 is suggested as a factor in Takayasu's arteritis and gallstones in Mexico.[4] Osteoarticular complications of

MICA-A9 which tightly linked to HLA-B39.[10][11] B39 also appears to be involved in the Fishers syndrome variant of Guillain–Barré syndrome.[12]

B39 appears to be protective against cardiomyopathy in

Chaga's disease indicating a possible selective factor in its rise in the New World.[13] Chaga's disease is caused by a trypanosome
carried by a blood sucking insect found in tropical, palm growing regions.

Southern California now reports cases of Chaga's disease from contaminated transfusions and may be already a habitat for the vector.[14]

In Takayasu's arteritis

ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.[17] B*3906, common in indigenous Mesoamericans has been found associated with the same disease.[18]

HLA B*3902 frequencies
freq
ref. Population (%)
[3] Mexico Mixe Oaxaca 38.7
Mexico Zaptotec Oaxaca 13.4
Mexico Mixtec Oaxaca 5.9
Mexico Mestizos 1.2
Japan pop5 0.9
Cuban White 0.7
Israel Ashk. and Non Ashk. Jews 0.5
Japan Central 0.5
Senegal Niokholo Mandenka 0.5
B*3903
PNG New Britain Rabaul 13.2
Brazil Terena 11.2
Argentina Toba Rosario 5.2
Brazil 0.7
Finland 0.6
Kenya Luo 0.6
North American Natives 0.5
B*3904
Argentina Toba Rosario 1.2
Georgia Svaneti Svans 0.6
Jordan Amman 0.3
Shijiazhuang Tianjian Han 0.1
Japan Central 0.1
Romanian 0.1
B*3905
Venezuela Perija Yucpa 36.1
Mexico Zaptotec Oaxaca 12.7
Mexico Mixtec Oaxaca 9.8
Mexico Mestizos 4.9
Arizona Pima 4.5
Mexico Guadalajara Mestizos 2.4
Argentina Toba Rosario 2.3
USA Hispanic 2.1
Mexico Mixe Oaxaca 1.9
Cuban White 1.4
Mexico Chihuahua Tarahumara 1.1
USA North American Natives 0.5
Shijiazhuang Tianjian Han 0.2
B*3907
Shijiazhuang Tianjian Han 0.6
Singapore Thai 0.5
China South Han 0.2
B*3908
Mexico Zaptotec Oaxaca 2.2
Mexico Mestizos 1.2
Mexico Mixtec Oaxaca 1.0
Brazil 0.7
USA Hispanic 0.6
B*3909
Venezuela Perija Yucpa 34.9
Thailand pop3 3.1
Brazil Terena 1.7
China South Han 1.4
Argentina Toba Rosario 1.2
China Qinghai Hui 0.9
B*3910
Sudanese 2.5
Senegal Niokholo Mandenka 2.1
South African Natal Zulu 1.5
Cameroon Beti 1.4
Spain Eastern Andalusia 1.2
Kenya Luo 1.1
Israel Arab Druse 1.0
Kenya Nandi 1.0
Guinea Bissau 0.8
Kenya 0.7
Mali Bandiagara 0.7
Morocco Nador Metalsa Class I 0.7
Cameroon Bamileke 0.6
Cameroon Yaounde 0.5
Israel Ashk. and Non Ashk. Jews 0.5
Saudi Arabia Guraiat and Hail 0.5

References

  1. PMID 20356336
    .
  2. ^ derived from IMGT/HLA
  3. ^
    PMID 12753660
    .
  4. PMID 15554998
    .
  5. PMID 12734905
    .
  6. PMID 9920028
    .
  7. PMID 10910175
    .
  8. PMID 8076387
    .
  9. PMID 7779129
    .
  10. PMID 11881819
    .
  11. PMID 12022360. Archived from the original
    on 2008-12-04. Retrieved 2008-08-03.
  12. PMID 8498847
    .
  13. PMID 14700597
    .
  14. ^ "Chagas Disease Represents New Challenge for Blood Supply Safety".
  15. PMID 9119528
    .
  16. PMID 7903491
    .
  17. PMID 9951811
    .
  18. PMID 9951813
    .
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