Junying Yuan

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The native form of this personal name is Yuan Junying. This article uses Western name order when mentioning individuals.
Junying Yuan
Born (1958-10-03) October 3, 1958 (age 65)
Shanghai, China
NationalityAmerican
Alma materFudan University
Harvard University
Massachusetts Institute of Technology
Known forApoptosis research
Necroptosis
Scientific career
FieldsBiology
Cell death
InstitutionsHarvard Medical School
Doctoral advisorH. Robert Horvitz

Junying Yuan (Chinese: 袁钧瑛; pinyin: Yuán Jūnyīng, born October 3, 1958) is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School,[1] best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.[2][3] More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.[4]

Education and early career

Yuan was born in

National Higher Education Entrance Examination in 1977, coming in first of all students who attempted it in Shanghai.[citation needed] She completed her bachelor's in biochemistry in 1982, and was subsequently one of the first students admitted to doctoral study in the United States through the China-U.S. Biochemistry Examination and Application (CUSBEA) program, coming in second out of the 25,000 who attempted the CUSBEA in its first year.[5]

In the United States, she completed her

caspase-1.[2][3][6]

Career

Junying Yuan established an independent lab at Harvard-affiliated Massachusetts General Hospital in 1989, immediately upon completion of her Ph.D. [5] Her initial efforts were directed towards providing evidence for the functional role of caspases in mediating mammalian apoptosis.[7][8] Her independent work at this stage provided the first insights into molecular mechanisms in mammalian apoptosis, which contributed significantly to the Nobel Prize in Chemistry won by her Ph.D. supervisor, Robert Horvitz.[9]

In 1996, Yuan moved her lab to the Department of

caspase-1-driven inflammation.[11]

In 2005, Yuan's group discovered a non-apoptotic form of programmed

TNFR family of death-domain receptors (DR) activated a canonical apoptotic pathway; however, in many cell types, not only did caspase inhibition fail to inhibit cell death, as would be expected of canonical apoptosis, but stimulated cells experienced a form of cell death that more closely resembled necrosis than apoptosis.[12] Yuan's group conducted a chemical screen that identified a small molecule capable of inhibiting DR-driven cell death, necrostatin-1, and demonstrated necroptosis' role in ischemic neuronal injury, thereby positing a potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1,[13]
thus implicating it as a key player in necroptosis.

Yuan went on to identify and characterize members of the signaling network responsible for regulating necroptosis,

amyotrophic lateral sclerosis (ALS), Alzheimer's disease, rheumatoid arthritis, psoriasis, and Crohn's disease.[16]

Awards and Fellowships

References

  1. ^ "Yuan Named Hay Professor of Cell Biology". HMS News. Retrieved 13 May 2015.
  2. ^
    PMID 2307287
    .
  3. ^
    PMID 1286611
    .
  4. ^
    S2CID 866321
    .
  5. ^ a b "Junying Yuan" (PDF). ASCB Profile. Retrieved 13 May 2015.
  6. PMID 8242740
    .
  7. PMID 8242741
    .
  8. S2CID 19330119
    .
  9. ^ "H. Robert Horvitz - Nobel Lecture: Worms, Life and Death" (PDF). Nobel Prize. Retrieved 14 May 2015.
  10. PMID 9727492
    .
  11. PMID 10791975
    .
  12. PMID 9730893
    .
  13. PMID 18408713
    .
  14. PMID 19109899
    .
  15. PMID 25087983
    .
  16. PMID 31110005
    .
  17. ^ "Fellows of the Foundation". Albert J. Ryan Foundation. Retrieved 13 May 2015.
  18. ^ "Wilson S. Stone Memorial Award Recipients" (PDF). Archived from the original (PDF) on 10 September 2015. Retrieved 13 May 2015.
  19. ^ a b c d "Junying Yuan - Curriculum Vitae". Archived from the original on 2016-03-04. Retrieved 2015-05-16.
  20. ^ "Innovator Award Recipients from the DOD Breast Cancer Research Program". U.S. Army Medical Research and Materiel Command. Retrieved 13 May 2015.
  21. ^ "Awardees". celldeath-apoptosis.org (ICDS). Archived from the original on 25 February 2015. Retrieved 13 May 2015.
  22. ^ "Junying Yuan". American Academy of Arts and Sciences. Retrieved 14 May 2015.
  23. ^ "AAAS Members Elected as Fellows". American Association for the Advancement of Science. Retrieved 14 May 2015.
  24. ^ "Agilent Technologies Thought Leader Award Supports Dr. Junying Yuan, Chinese Academy of Sciences". Agilent Technologies. Retrieved 13 May 2015. {{cite news}}: External link in |work= (help)
  25. ^ "May 2, 2017: NAS Members and Foreign Associates Elected".

External links

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