List of adverse effects of chlorpromazine
Chlorpromazine includes the following list of adverse effects (serious adverse effects appear in bold):[Note 1][1][2][3][4][5]
Very common
- Sedation (cf. "Thorazine shuffle" – a shuffling gait due to sedation)
- Somnolence
- Extrapyramidal symptoms[Note 2]
- Weight gain
- Orthostatic hypotension[Note 3]
- Dry mouth
- Constipation
Common
- ECG changes[Note 4]
- Contact dermatitis
- Sensitivity to light
- Urticaria(hives)
- Maculopapular rash
- Petechia or edema
- Hyperprolactinaemia[Note 5]
- Impaired thermoregulation[Note 6]
- Hyperglycaemia[Note 7]
- Other hypothalamic abnormalities[Note 8]
- Blurred vision
- Confusion
- Raised ANAtitre
- Positive SLEcells
- Mydriasis[Note 9]
- Atonic colon
- Seizure[Note 10]
- Psychomotor agitation|Agitation (restlessness)
- Pain at the injection site
- Injection site abscess
Uncommon
- Miosis[Note 11]
- Urinary retention[Note 12]
- Nasal congestion
- Nausea
- Obstipation
- Arrhythmias
- Skin pigmentation
- Glycosuria[Note 13]
- Hypoglycaemia[Note 14]
- Paralytic ileus
Rare
- Agranulocytosis[Note 15]
- Haemolytic anaemia[Note 16]
- Aplastic anaemia[Note 17]
- A-V block[Note 18]
- Hypertensive crises[Note 19]
- Thrombocytopenic purpura
- Exfoliative dermatitis
- Toxic epidermal necrolysis[Note 20]
- Systemic lupus erythematosus[Note 21]
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)[Note 22]
- Water retention
- Cholestatic jaundice
- Liver injury
- Neuroleptic malignant syndrome[Note 23]
- Myasthenia gravis[Note 24]
Unknown frequency
- Leucopaenia[Note 25]
- Eosinophilia[Note 26]
- Pancytopaenia[Note 27]
- Priapism[Note 28]
- Photophobia[Note 29]
- Corneal deposits
- Respiratory depression[Note 30]
- Ventricular tachycardia
- QT interval prolongation
- Atrial fibrilation
- Hyperthermia[Note 31]
- Hypothermia[Note 32]
- Galactorrhoea[Note 33]
- Breast enlargement in either sex
- False-positive pregnancy tests
- Allergic reaction
- Fits
- Cerebral oedema[Note 34]
- Urinary incontinence
- Coagulation defects
- Nightmares
- Abnormality of cerebrospinal fluid proteins
- Dysphoria[Note 35]
- Catatonic excitement
- Narrow angle glaucoma
- Optic atrophy
- Pigmentary retinopathy
- Amenorrhoea[Note 36]
- Infertility
- Tardive dyskinesia[Note 37]
Notes
- ^ Data on the exact incidence of the different adverse effects is greatly lacking so only rough approximations of adverse effect incidence is available
- ^ Refer to main text below for details on this adverse effect
- ^ A drop in blood pressure that results from standing up
- ^ A disturbance in the electrical cycle of the heart
- amenorrhoea (the absence of the menstrual period in women). Whereas in the long-term hyperprolactinaemia can result in osteoporosis(brittle bones).
- ^ An impaired ability to regulate one's body temperature
- ^ High blood glucose (sugar) levels
- ^ The hypothalamus of the brain regulates the release of a number of hormones as well as a few "housekeeping" functions such as tight control over body temperature
- ^ Widening (dilation) of the pupils
- ^ Refer to the text below for details
- ^ Constriction of the pupils of the eyes
- ^ Being unable to pass urine
- nephrons of the kidney.
- ^ Low blood glucose (sugar)
- leucopaenia. It occurs when the white blood cell(WBC) count drops below 5% of the norm
- red blood cellsof the body die breakdown to an abnormal extent. These cells carry oxygen across the body from the lungs
- ^ Where the bone marrow stops adequately (in order to replenish the blood cells that die off every day) producing new blood cells
- ^ An abnormality in the electrical activity of the heart which can lead to potentially fatal changes in heart rhythm
- ^ Dangerously (in the short-term) high blood pressure
- ^ A dangerous skin reaction
- ^ An autoimmune reaction
- antidiuretic hormone(ADH). This in turn increases the reabsorption of
- rigidity, tremor, diarrhoea, tachycardia, altered mental status (e.g. confusion, mania, hallucinations, etc.) and hyperthermia(high body temperature)
- ^ An autoimmune condition in of which the body's defences attack the neuromuscular junction – the gap between muscle and nerve cells across which the nerves send messages to the muscle cells
- white blood cellsin the blood. These cells defend the body from infections and hence this can heighten one's risk of infections
- eosinophils– the cells of the immune system that defends the body from parasites
- ^ An abnormally low number of all three major groups of blood cells including the red blood cells, white blood cells and platelets
- ^ A painful and sustained (usually a few hours) erection
- ^ Fear of light
- ^ A reduction in the normal homeostatic breathing reaction to reductions in plasmacarbon dioxide levels
- ^ High body temperature
- ^ Low body temperature
- ^ Lactation that is unassociated with lactation or breastfeeding
- ^ The accumulation of fluid in the tissues of the brain
- ^ Basically the opposite to euphoria
- ^ The absence of menstrual periods
- ^ An often irreversible and sometimes even fatal movement disorder characterised by involuntary, repetitive and purposeless movements of the face, extremities, lips or tongue. Usually takes a number of years to develop but in some it can appear within months or less since the initiation of antipsychotic treatment
References
- ^ "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Retrieved 8 December 2013.
- ^ "Chlorpromazine Hydrochloride 100mg/5ml Oral Syrup - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Rosemont Pharmaceuticals Limited. 6 August 2013. Retrieved 8 December 2013.
- ^ "CHLORPROMAZINE HYDROCHLORIDE tablet, film coated [Sandoz Inc]". DailyMed. Sandoz Inc. October 2011. Retrieved 8 December 2013.
- ^ "CHLORPROMAZINE HYDROCHLORIDE injection [West-ward Pharmaceutical Corp.]". DailyMed. West-ward Pharmaceutical Corp. June 2012. Retrieved 8 December 2013.
- ^ "Largactil Injection - Summary of Product Characteristics". electronic Medicines Compendium. Sanofi. 10 May 2013. Retrieved 8 December 2013.