Mary F. Lyon

Source: Wikipedia, the free encyclopedia.
This article is about the 20th century British geneticist. For the 19th century American educator, see Mary Lyon.

Mary Lyon
X-chromosome inactivation[3]
Awards
Scientific career
InstitutionsUniversity of Edinburgh
Doctoral advisorRonald Fisher
Doctoral studentsElizabeth Fisher[2]

Mary Frances Lyon

X-chromosome inactivation, an important biological phenomenon.[6][7][8][9][10][11][12]

Early life and education

Mary Lyon was born on 15 May 1925 in Norwich, England as the eldest out of three children of a civil servant and a

schoolteacher
. She was educated at a grammar school in Birmingham. During that time, she said, she became interested in science thanks to a good schoolteacher[13] and nature books she won in an essay competition.[14] During the Second World War in 1943, she began her studies at Girton College, Cambridge at the University of Cambridge,[15] where she read zoology, physiology, organic chemistry and biochemistry, with zoology as her main subject. At this time, only 500 (less than 10%) female students were allowed to study at the university, in contrast to more than 5,000 men. Furthermore, despite doing the same work as male students, female students received only “titular" degrees, rather than full Cambridge degrees that would make them members of the university.[14] During her studies at Cambridge, she became interested in embryology. She went on to do her PhD with Ronald Fisher, who was Professor of Genetics in Cambridge, where she characterised a mutant mice strain with a 'pallid' mutation and published the research. During the course of her PhD she moved to the University of Edinburgh, where she completed her studies under the direction of Douglas Falconer.[16]

Research and career

After her PhD (awarded 1950

Medical Research Council, and she worked with TC Carter to investigate mutagenesis and the genetic risks of radiation.[16]
In addition to the 'pallid' mutation mice, she studied mutations such as 'ataxia' (a nervous mutation which caused walking difficulties in the mice) and 'twirler' (a mutation which induced inner ear issues, causing the mice to shake their heads and walk in circles due to lack of balance).

In 1955, her group moved to the MRC radiobiology unit in Harwell, where there was room for more mouse facilities. There she continued to investigate the mouse mutations. She also scrutinised a 'mottled' mutant, which had a different effect on male and female mice: male embryos sometimes died, and the surviving males had white coats, but females lived and were variegated. Through calculated and deliberated breeding of mutants, she investigated the transition of the mutation and concluded that the mutation was positioned on the X chromosome. This, together with new findings at that time concerning the X chromosome, led her to hypothesize about X chromosome silencing.[14]

Lyon published many papers on radiation and chemical mutagenesis and on studies of mutant genes.[18] She also did extensive work on the mouse t-complex.[19][20]

She was head of the Genetics Section of the MRC Radiology Unit at Harwell from 1962 to 1987. Although she retired from research in 1990, according to an interview from 2010, she was still active in the laboratory a few times a week.[14]

X-inactivation

It was while working on radiation hazards in 1961 that she discovered

X-linked genetic disorders can display mild symptoms.[21]

Awards and honours

Library resources about
Mary F. Lyon
By Mary F. Lyon

Lyon was elected a

US National Academy of Sciences, and a Foreign Honorary Member of the American Academy of Arts and Sciences. In 1994 she won the Mauro Baschirotto Award in Human Genetics, in 1997 the Wolf Prize for Medicine, for her hypothesis concerning the random inactivation of X-chromosomes in mammals. In 1997 she also received the Amory Prize, for genetic discoveries relating to mammalian sex chromosomes.[22] In 2004 she was awarded the March of Dimes Prize in Developmental Biology. In 2006 she received the Pearl Meister Greengard Prize awarded by the Rockefeller University
.

Since 2015 The Genetics Society has awarded the Mary Lyon Medal in her honour.

Other awards and honours include:

Her nomination for the

dosage compensation in the female mammal, has thrown much light on the nature of sex-chromosome aneuploidy, has influenced ideas on the origin of certain tumours and of chronic granulocytic leukaemia in man, and has provided food for thought about the fundamental mechanism of switching off genes. Lyonisation, as others were quick to call the phenomenon, has perhaps opened more lines of enquiry and stimulated more work than any recent biological concept.[4]

Legacy

In 2018, the International Mammalian Genome Society established the Mary Lyon Award in recognition her role as a mentor and her remarkable career which began in a time period where very few women became scientists. The award is presented annually to early- and mid-stage independent female researchers.[16]

References

  1. ^
    doi:10.1093/ww/9780199540884.013.U25200. (Subscription or UK public library membership
    required.)
  2. EThOS uk.bl.ethos.769180. Free access icon
  3. S2CID 46853044
    .
  4. ^ a b c d "EC/1973/19: Lyon, Mary Frances". London: The Royal Society. Archived from the original on 8 July 2019.
  5. ^ "Mary Lyon, geneticist – obituary". The Daily Telegraph. 3 February 2015. Retrieved 4 March 2015.
  6. PMID 25652989
    .
  7. ^ "Formal portrait of Mary Lyon by Godfrey Argent". London: The Royal Society. Archived from the original on 8 July 2019.
  8. ^ Mary Lyon Entry in Who named it?. Retrieved 4 March 2015.
  9. ^ Oakes, Elizabeth H. Lyon, Mary Frances. International Encyclopedia of Women Scientists. New York, NY. Facts on File, Inc. 2002. Facts on File, Inc. Science Online. factsonfile.com.
  10. S2CID 4146768
    .
  11. PMID 28947664
    .
  12. PMID 28947653. Open access icon
  13. ^ "Genetics and Medicine Historical Network".
  14. ^
    PMID 20107603
    .
  15. ^ a b Peter Harper (11 October 2004). "Mary Lyon". Genetics and Medicine Historical Network, Cardiff University.
  16. ^ a b c "Mary Lyon Award". International Mammalian Genome Society.
  17. ISBN 978-0-19-861412-8
    .
  18. ^ Mary F. Lyon's publications indexed by the Scopus bibliographic database. (subscription required)
  19. S2CID 30795392
    .
  20. S2CID 39402646
    .
  21. PMID 9445416
    .
  22. PMID 14467629
    .
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