POLR2A
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 7.48 – 7.51 Mb | Chr 11: 69.62 – 69.65 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.
Function
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.[5]
Interactions
POLR2A has been shown to
interact
with:
- BRCA1,[6][7][8][9]
- CREBBP,[10]
- CTDP1,[7]
- CDK8,[10]
- GTF2B,[7]
- GTF2F1,[7][10]
- GTF2H4,[7]
- MED21,[7][10][11]
- MED26,[12]
- PCAF,[10]
- POLR2C,[13]
- POLR2E,[13]
- POLR2H,[13]
- POLR2L,[13]
- PQBP1,[14]
- SMARCA2,[10][15][16]
- SMARCA4[15][16][17]
- SMARCB1,[10][15][16]
- SMYD3,[18]
- SND1,[19]
- SUPT5H,[20][21]
- TAF11,[7]
- TBP,[7]
- TCEA1,[22][23][24]
- TCERG1,[25] and
- ZNF74.[26]
References
- ^ a b c ENSG00000181222 GRCh38: Ensembl release 89: ENSG00000284832, ENSG00000181222 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005198 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa".
- PMID 14506230.
- ^ PMID 9159119.
- PMID 11504724.
- PMID 12955082.
- ^ PMID 9710619.
- PMID 9315662.
- PMID 15175163.
- ^ PMID 9201987.
- S2CID 15993809.
- ^ PMID 11238380.
- ^ PMID 8895581.
- S2CID 3184211.
- S2CID 13456531.
- PMID 12234934.
- PMID 10454543.
- PMID 9450929.
- S2CID 14209300.
- PMID 9765293.
- PMID 9305922.
- PMID 10908677.
- PMID 9346935.
Further reading
- Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.
- Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. S2CID 15480646.
- Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. S2CID 43685090.
- Szentirmay MN, Sawadogo M (2000). "Spatial organization of RNA polymerase II transcription in the nucleus". Nucleic Acids Res. 28 (10): 2019–25. PMID 10773068.
- Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. S2CID 10931640.