Prostaglandin-E2 9-reductase
| prostaglandin-E2 9-reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a prostaglandin-E2 9-reductase (EC 1.1.1.189) is an enzyme that catalyzes the chemical reaction
- (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
Thus, the two
substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate and NADP+, whereas its 3 products are (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate, NADPH, and H+
.
This enzyme belongs to the family of
arachidonic acid metabolism
.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with PDB accession codes 1Q13, 1Q5M, and 2PFG
.
References
- Lee SC, Levine L (1975). "Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase". J. Biol. Chem. 250 (12): 4549–55. PMID 166995.
- Schlegel W, Kruger S, Korte K (1984). "Purification of prostaglandin E2 reductase-9-oxoreductase from human decidua vera". FEBS Lett. 171 (1): 141–4. S2CID 25623206.
- Tai HH, Yuan B (1982). "Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney". Methods Enzymol. 86: 113–7. PMID 7132747.
- Watkins JD, Jarabak J (1985). "The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney". Prostaglandins. 30 (2): 335–49. PMID 3901124.