SIGLEC10
| SIGLEC10 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 19: 51.41 – 51.42 Mb | Chr 7: 43.06 – 43.07 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10 [7]
Structure and function
Like most but not all other Siglecs, Siglec-10 bears an ITIM (
Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24
also known as HSA (Heat-stable antigen).
Gene family summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142512 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030468 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11284738.
- ^ a b "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
- PMID 30130255.
- S2CID 11457712.
Further reading
- Li N, Zhang W, Wan T, et al. (2001). "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells". J. Biol. Chem. 276 (30): 28106–12. PMID 11358961.
- Yousef GM, Ordon MH, Foussias G, Diamandis EP (2001). "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants". Biochem. Biophys. Res. Commun. 284 (4): 900–10. PMID 11409878.
- Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone". Nat. Cell Biol. 4 (7): 495–501. S2CID 4795393.
- Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1". Biochem. Biophys. Res. Commun. 296 (2): 355–62. PMID 12163025.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMID 16344560.
- Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. PMID 17672918.
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