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Protein-coding gene in the species Homo sapiens
SIGLEC7 Gene ontology
Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Wikidata
Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene .[3] [4] SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).
References
Further reading
Reif K, Buday L, Downward J, Cantrell DA (1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases" . J. Biol. Chem . 269 (19): 14081–7. .
Falco M, Biassoni R, Bottino C, et al. (1999). "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells" . J. Exp. Med . 190 (6): 793–802. .
Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction" . J. Biol. Chem . 274 (42): 30202–8. .
Vitale C, Romagnani C, Falco M, et al. (2000). "Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells" . Proc. Natl. Acad. Sci. U.S.A . 96 (26): 15091–6. .
Angata T, Varki A (2000). "Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily" . Glycobiology . 10 (4): 431–8. .
Ito A, Handa K, Withers DA, et al. (2001). "Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression" . FEBS Lett . 498 (1): 116–20. .
Mingari MC, Vitale C, Romagnani C, et al. (2001). "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors". Progress in Basic and Clinical Immunology . Advances in Experimental Medicine and Biology. Vol. 495. pp. 55–61. .
Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene . 286 (2): 259–70. .
Alphey MS, Attrill H, Crocker PR, van Aalten DM (2003). "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family" . J. Biol. Chem . 278 (5): 3372–7. .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. .
Nicoll G, Avril T, Lock K, et al. (2003). "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms" . Eur. J. Immunol . 33 (6): 1642–8. .
Dimasi N, Moretta A, Moretta L, et al. (2004). "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1". Acta Crystallogr. D . 60 (Pt 2): 401–3. .
Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9" . J. Biol. Chem . 279 (41): 43117–25. .
Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells" . J. Immunol . 173 (11): 6841–9. .
Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y (2005). "Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs" . Glycobiology . 15 (7): 667–76. .
Attrill H, Takazawa H, Witt S, et al. (2006). "The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design" . Biochem. J . 397 (2): 271–8. .
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc . 71 (5): 496–504. .
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res . 31 (2): 211–20. .
PDB gallery
1nko : Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7
1o7s : HIGH RESOLUTION STRUCTURE OF SIGLEC-7
1o7v : HIGH RESOLUTION STRUCTURE OF SIGLEC-7
2df3 : The structure of Siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl
2g5r : Crystal structure of Siglec-7 in complex with methyl-9-(aminooxalyl-amino)-9-deoxyNeu5Ac (oxamido-Neu5Ac)
2hrl : Siglec-7 in complex with GT1b
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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