SLX4
SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination.[5] Mutations in the gene are associated with the disease Fanconi anemia.[6][7]
The version of SLX4 present in humans and other mammals acts as a sort of scaffold upon which other proteins form several different
multiprotein complexes. The SLX1-SLX4 complex acts as a Holliday junction resolvase. As such, the complex cleaves the links between two homologous chromosomes that form during homologous recombination. This allows the two linked chromosomes to resolve into two unconnected double-strand DNA molecules.[8] The SLX4 interacting protein interacts with SLX4 in the DNA repair process, specifically in interstrand crosslink repair.[9] SLX4 also associates with RAD1, RAD10 and SAW1 in the single-strand annealing pathway of homologous recombination.[10] The DNA repair function of SLX4 is involved in sensitivity to proton beam radiation.[11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188827 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039738 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 15429205.
- PMID 21240275.
- PMID 21722353.
- PMID 19596235.
- PMID 31495888.
- PMID 19473888.
- PMID 27084631.
External links
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