SYT7
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| Location (UCSC) | Chr 11: 61.51 – 61.58 Mb | Chr 19: 10.37 – 10.43 Mb | |||||||
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Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.[5][6]
Function
Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM][6]
Interactions
SYT7 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9615227.
- ^ a b "Entrez Gene: SYT7 synaptotagmin VII".
- PMID 10734137.
Further reading
- Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. S2CID 4265549.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. PMID 8901523.
- Craxton M, Goedert M (November 1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Letters. 460 (3): 417–22. S2CID 19207631.
- Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Research. 9 (12): 1198–203. PMID 10613842.
- Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. PMID 10734137.
- Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW (May 2001). "The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi". The Journal of Experimental Medicine. 193 (9): 1097–104. PMID 11342594.
- Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K (July 2002). "Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human". The Biochemical Journal. 365 (Pt 1): 173–80. PMID 12071850.
External links
- Overview of all the structural information available in the PDB for UniProt: O43581 (Human Synaptotagmin-7) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB.
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