Susan Golden

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Susan Golden (née Stephens) is a Professor of

Golden was born in Pine Bluff, Arkansas in 1957.^[1] She attended the local public high school, where she was involved with the marching band and school newspaper. She was accepted to the Mississippi University for Women in 1976 as a journalism major, but soon switched her studies to major in biology and minor in chemistry.

Golden graduated from MUW in two years, after which she was offered a position in the first cohort of trainees in a NIH-financed doctoral program in genetics at the University of Missouri. During her graduate program, Golden met James Golden, a fellow doctoral student.^[2] They later married in 1979. At the University of Missouri, Golden researched the protein makeup of the photosynthetic center in cyanobacteria, work she continued when she moved to the University of Chicago in 1983 as a postdoctoral research fellow.^[1]

In 1986 Golden accepted a faculty position at Texas A&M to further her investigation into light-dependent gene regulation in bacteria. While at Texas A&M, Golden became interested in studying circadian rhythms after her first encounter with Carl H. Johnson and Takao Kondo, with whom she would go on to discover the Kai complex.^[2] Golden was promoted to Distinguished Professor at Texas A&M in 2003, and then moved to UC San Diego in 2008 where she is currently a Distinguished Professor and the Director of the Center for Circadian Biology.^[3]

Research contributions

Early work

Golden began her graduate career with Louis A. Sherman, where she used genetics to research the proteins in photosynthetic complexes of the cyanobacteria

After moving to UC San Diego in 2008, Susan Golden's research converged with that of her husband, James Golden, to investigate biofuels.^[2] She currently researches the potential of utilizing cyanobacteria for industrial production of biofuels. Cyanobacteria are attractive due to simplistic genomes and ability to be genetically modified for industrial efficiency. Their photosynthetic nature may ideally be used to produce sustainably produce biofuels, potentially replacing the need for petroleum and other fossil fuels.^[3] They have simple requirements for growth, only requiring sunlight, water, and inorganic trace elements for fast growth. Cyanobacteria are capable of fixing atmospheric carbon (carbon dioxide) into bio-oils and biofuels.^[11]

In 2016, Golden and colleagues manually curated a model of metabolism in S. elongatus, indicating the importance of a linear tricarboxylic acid cycle (TCA) metabolic pathway and potential modifications for bio-industrial application.^[12]

Honors, awards, and membership

• National Science Foundation Presidential Young Investigator Award, 1989 - 1995
• Fellow of the American Academy of Microbiology, elected in 2000
• Texas A&M Distinguished Professor, 2003
• Member of the Faculty of 1000 Biology, 2008 - 2015^[13]
• UC San Diego Distinguished Professor and Chancellor’s Associates Chair in Molecular Biology, 2008–present
• Member of the National Academy of Sciences, elected in 2010^[14]
• Howard Hughes Medical Institute Professor, 2014–present
• Aschoff and Honma Prize for Biological Rhythm Research, 2018^[15]

Selected publications

This section may contain excessive or irrelevant examples. Please help improve the article by adding descriptive text and removing less pertinent examples. (March 2022)

• Kondo T, Strayer CA, Kulkarni RD, Taylor W, Ishiura M, Golden SS, Johnson CH (1993). "Circadian rhythms in prokaryotes: luciferase as a reporter of circadian gene expression in cyanobacteria". Proc Natl Acad Sci USA. 90 (12): 5672–6.
  PMID 8516317.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Kondo T, Tsinoremas NF, Golden SS, Johnson CH, Kutsuna S, Ishiura M (1994). "Circadian clock mutants of cyanobacteria". Science. 266 (5188): 1233–6.
  PMID 7973706.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Liu Y, Golden SS, Kondo T, Ishiura M, Johnson CH (1995). "Bacterial luciferase as a reporter of circadian gene expression in cyanobacteria". J Bacteriol. 177 (8): 2080–6.
  PMID 7536731.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Golden SS (1995). "Light-responsive gene expression in cyanobacteria". J Bacteriol. 177 (7): 1651–4.
  PMID 7896684
  .

• Liu Y, Tsinoremas NF, Johnson CH, Lebedeva NV, Golden SS, Ishiura M, Kondo T (1995). "Circadian orchestration of gene expression in cyanobacteria". Genes Dev. 9 (12): 1469–78.
  PMID 7601351.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Tsinoremas NF, Ishiura M, Kondo T, Andersson CR, Tanaka K, Takahashi H, Johnson CH, Golden SS (1996). "A sigma factor that modifies the circadian expression of a subset of genes in cyanobacteria". EMBO J. 15 (10): 2488–95.
  PMID 8665856.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Johnson CH, Golden SS, Ishiura M, Kondo T (1996). "Circadian clocks in prokaryotes". Mol Microbiol. 21 (1): 5–11.
  S2CID 40431382.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Kondo T, Mori T, Lebedeva NV, Aoki S, Ishiura M, Golden SS (1997). "Circadian rhythms in rapidly dividing cyanobacteria". Science. 275 (5297): 224–7.
  S2CID 31261881.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Golden SS, Ishiura M, Johnson CH, Kondo T (1997). "Cyanobacterial circadian rhythms". Annu Rev Plant Physiol Plant Mol Biol. 48: 327–354.
  PMID 15012266.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Ouyang Y, Andersson CR, Kondo T, Golden SS, Johnson CH (1998). "Resonating circadian clocks enhance fitness in cyanobacteria". Proc Natl Acad Sci USA. 95 (15): 8660–4.
  PMID 9671734.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T (1998). "Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria". Science. 281 (5382): 1519–23.
  PMID 9727980.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Johnson CH, Golden SS, Kondo T (1998). "Adaptive significance of circadian programs in cyanobacteria". Trends Microbiol. 6 (10): 407–10.
  PMID 9807785.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Golden SS, Johnson CH, Kondo T (1998). "The cyanobacterial circadian system: a clock apart". Curr Opin Microbiol. 1 (6): 669–73.
  PMID 10066545.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Katayama M, Tsinoremas NF, Kondo T, Golden SS (1999). "cpmA, a gene involved in an output pathway of the cyanobacterial circadian system". J Bacteriol. 181 (11): 3516–24.
  PMID 10348865.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Johnson CH, Golden SS (1999). "Circadian programs in cyanobacteria: adaptiveness and mechanism". Annu Rev Microbiol. 53: 389–409.
  PMID 10547696
  .

• Andersson CR, Tsinoremas NF, Shelton J, Lebedeva NV, Yarrow J, Min H, Golden SS (2000). "Application of bioluminescence to the study of circadian rhythms in cyanobacteria". Bioluminescence and Chemiluminescence Part C. Methods in Enzymology. Vol. 305. pp. 527–42.
  PMID 10812624.{{cite book}}: CS1 maint: multiple names: authors list (link
  )

• Williams SB, Vakonakis I, Golden SS, LiWang AC (2002). "Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism". Proc Natl Acad Sci USA. 99 (24): 15357–62.
  PMID 12438647.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Ditty JL, Williams SB, Golden SS (2003). "A cyanobacterial circadian timing mechanism". Annu Rev Genet. 37: 513–43.
  S2CID 36703896.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Golden SS (2003). "Timekeeping in bacteria: the cyanobacterial circadian clock". Curr Opin Microbiol. 6 (6): 535–40.
  PMID 14662347
  .

• Golden SS (2004). "Meshing the gears of the cyanobacterial circadian clock". Proc Natl Acad Sci USA. 101 (38): 13697–8.
  PMID 15367731
  .

• Mackey SR, Golden SS (2007). "Winding up the cyanobacterial circadian clock". Trends Microbiol. 15 (9): 381–8.
  PMID 17804240
  .

• Kim YI, Dong G, Carruthers CW Jr, Golden SS, LiWang A (2008). "The day/night switch in KaiC, a central oscillator component of the circadian clock of cyanobacteria". Proc Natl Acad Sci USA. 105 (35): 12825–30.
  PMID 18728181.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Dong G, Golden SS (2008). "How a cyanobacterium tells time". Curr Opin Microbiol. 11 (6): 541–6.
  PMID 18983934
  .

• Chen Y, Kim YI, Mackey SR, Holtman CK, Liwang A, Golden SS (2009). "A novel allele of kaiA shortens the circadian period and strengthens interaction of oscillator components in the cyanobacterium Synechococcus elongatus PCC 7942". J Bacteriol. 191 (13): 4392–400.
  PMID 19395479.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Dong G, Yang Q, Wang Q, Kim YI, Wood TL, Osteryoung KW, van Oudenaarden A, Golden SS (2010). "Elevated ATPase activity of KaiC applies a circadian checkpoint on cell division in Synechococcus elongatus". Cell. 140 (4): 529–39.
  PMID 20178745.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Dong G, Kim YI, Golden SS (2010). "Simplicity and complexity in the cyanobacterial circadian clock mechanism". Curr Opin Genet Dev. 20 (6): 619–25.
  PMID 20934870.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Cohen SE, Golden SS (2015). "Circadian Rhythms in Cyanobacteria". Microbiol Mol Biol Rev. 79 (4): 373–85.
  PMID 26335718
  .

• Rubin BE, Wetmore KM, Price MN, Diamond S, Shultzaberger RK, Lowe LC, Curtin G, Arkin AP, Deutschbauer A, Golden SS (2015). "The essential gene set of a photosynthetic organism". Proc Natl Acad Sci USA. 112 (48): E6634–43.
  PMID 26508635.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

• Tseng R, Goularte NF, Chavan A, Luu J, Cohen SE, Chang YG, Heisler J, Li S, Michael AK, Tripathi S, Golden SS, LiWang A, Partch CL (2017). "Structural basis of the day-night transition in a bacterial circadian clock". Science. 355 (6330): 1174–1180.
  PMID 28302851.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )

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