Taenia asiatica

Source: Wikipedia, the free encyclopedia.

Taenia asiatica
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Animalia
Phylum: Platyhelminthes
Class: Cestoda
Order: Cyclophyllidea
Family: Taeniidae
Genus: Taenia
Species:
T. asiatica
Binomial name
Taenia asiatica

Taenia asiatica, commonly known as Asian taenia or Asian tapeworm, is a

molecular phylogeny
in the late 2000s established the taxonomic status.

T. asiatica causes intestinal taenisis in humans and

digestive tract, which they penetrate to migrate to other body organs. Unlike other Taenia they preferentially settle in the liver
, where they form cysticerci.

Asian taeniasis is documented in nine countries in

economic losses of about US$40,000,000 in these regions.[5] Praziquantel is the drug of choice for treating the infection. As the latest addition to human taeniasis, misidentified for over two centuries, still complete lack of systematic diagnosis, and no control programmes, it is regarded as the most neglected human taenid.[6]

Discovery

T. asiatica was first recognized in Taiwan, and subsequently in

In 1992 two Korean parasitologists Keeseon S. Eom, from

novel species, Taenia asiatica, in 1993.[1]

Even then scepticism still persisted. Considering the degree of variations between Taiwan strain and typical T. saginata, Taiwanese parasitologists such as P.C. Fan, C.Y Lin, C.C. Chen and W.C Chung from

gene) with those of Taenia solium and T. saginata provided further support to its taxonomic status.[23] The complete sequence of mitochondrial genome of T. saginata in 2007,[24] and the development of high-resolution multiplex PCR assay in 2009[25] finally established beyond doubt that it is indeed a new species. The two species separated 1.14 million years ago.[26]

Description

The body of Taenia asiatica is yellowish-white in colour, about 350 cm long and 1 cm broad, divided into the anterior

gravid proglottid, which are absent in other taenids including T. saginata.[28]

The cysticerci of T. asiatica are typically smaller than those of other human taenids. They possess two rows of rudimentary hooks, unlike T. saginata, which has none.[10][11] In addition the protoscolex of cysticercus (metacestode) has a sunken rostellum, while that of T. saginata has only an apical pit.[17]

Life cycle

The

faeces along with the gravid proglottid which gets detached from the strobila. The number of proglottids released per day may vary from 0 to 35. Cysticercus grows into adult in about 2.5 to 4 months, by the time gravid proglottids are found in faeces.[29]

Pigs and wild boars ingest the infective

circulation of the host. This is where the young larval stages form a pea-sized, fluid filled cyst, also known as “cysticercus”, which migrate to visceral organs like liver, serosa and lungs in pigs, and liver in cattle.[8] In contrast to T. saginata, the larval development is short, taking about four weeks. Cystecerci have a predilection for liver.[30]

Pathogenesis

T. asiatica infection in human is usually asymptomatic. There was an isolated report of severe pathogenic lesions in a 60-year-old woman admitted to Mackay Memorial Hospital in Taiwan. Using endoscopy she was diagnosed with multiple erosions and active bleeding from ulcers in the stomach and duodenum caused by a single tapeworm. A year later she returned with intermittent epigastric pain, which she reported having had for several months. Again a tapeworm was seen.[31] The tapeworm species was not identified but was suspected to be T. asiatica, because the woman ate pork liver at a festival, and the common pork tapeworm T. solium is mostly found in pig muscle.[32]

In pigs cysticercus has a tendency to produce cysticercosis. Cysts are formed in vital organs such as liver and lungs. In contrast T. saginata does not cause cysticercosis.[33] As its life cycle and mode of development are very similar to those of Taenia solium, which is the major cause of neurocysticercosis, a possibility that T. asiatica can cause cysticercosis in humans is highly conjectured.[6][16][34]

Epidemiology

The

parasite is known in Asian countries including Taiwan, Korea, Indonesia, Nepal, Thailand and China. In addition, molecular genotyping techniques have revealed that the disease also occurs in Japan, the Philippines, and Vietnam.[35][36]

Diagnosis

The basic

sympatric distribution. Identification often requires histological observation of the uterine branches and PCR detection of ribosomal 5.8S gene.[37][38] The presence of rostellum on the scolex, a large number of uretine branches (more than 57) and prominent posterior protuberances in gravid proglottids, and wart-like formation on the surface of the larvae are the distinguishing structures.[1][28]

To date the most relevant diagnosis of taeniasis due to T. asiatica is by enzyme-linked immunoelectrotransfer blot (EITB). EITB can effectively identify it from other taenid infections since

false positive result. Loop-mediated isothermal amplification (LAMP) is highly sensitive (~2.5 times that of multiplex PCR), without false positive, for differentiating the taenid species from faecal samples.[40]

Treatment

Niclosamide (2 mg) is very effective against experimental infection in human.

benzimidazoles are relatively ineffective. Praziquantel at a single dose of 150 mg is the most effective medication against T. asiatica without causing side effects.[41]

Genome

References

External links