Trubion

Trubion
	Seattle, WA
Products	Protein-based therapeutics
Website	www.trubion.com

Trubion was a publicly held

State of Delaware

.

In December 2005, Trubion entered into a collaborative agreement with Wyeth^[2] for the development and worldwide commercialization of CD20-directed therapeutics. The agreement also included the development and worldwide commercialization of certain other product candidates directed to targets other than CD20. The research portion of Trubion's contract with Wyeth extended through December 22, 2009.

Former product pipeline

Name	Platform	Indication	Status	Collaboration	Research
TRU-015	SMIP	Rheumatoid arthritis	Phase 2b	Wyeth	Phase 2b initiation^[3] EULAR data^[4]
SBI-087	SMIP	Rheumatoid arthritis	Phase 1	Wyeth	Recent data^[4]
SBI-087	SMIP	Systemic lupus erythematosus	Phase 1	Wyeth
TRU-016	SMIP	Chronic lymphocytic leukemia	Phase 1/2	Trubion Proprietary Technology	ASCO 2008 Poster Presentation^[5]
TRU-016	SMIP	Non-Hodgkin lymphoma	Pre-clinical	Trubion Proprietary Technology
TRU-016	SMIP	Autoimmune disease and inflammation	Pre-clinical	Trubion Proprietary Technology

Former technology

Trubion's product development efforts were focused on three technology pillars: SMIP protein therapeutics, SCORPION protein therapeutics, and TRU-ADhanCe potency enhancing technology for immunopharmaceuticals.

SMIP, or

mAbs

.

SCORPION protein therapeutics are also single chain polypeptides composed of functional domains from naturally occurring proteins. The difference between SMIP and SCORPION technologies is that SCORPION compounds are multi-specific therapeutics that are capable of targeting two or more antigens simultaneously.

TRU-ADhanCe potency enhancing technology was designed to enhance the potency of existing therapies that work through Fc-directed or antibody-directed cellular cytotoxicity, or

ADCC. TRU-ADhanCe technology could be applied late in development to established manufacturing lines and generate candidates with increased ADCC and longer in vivo

half lives.

References

^ "Emergent BioSolutions Completes Acquisition of Trubion Pharmaceuticals | Reuters". www.reuters.com. Archived from the original on 5 December 2014. Retrieved 13 January 2022.
^ "Wyeth.com | CBD - Trubion Alliance". Archived from the original on 2008-08-28. Retrieved 2008-07-30.
^ http://investors.trubion.com/releasedetail.cfm?ReleaseID=308846^{[permanent dead link‍]}
^ ^a ^b http://investors.trubion.com/releasedetail.cfm?ReleaseID=316893^{[permanent dead link‍]}
^ "Archived copy" (PDF). files.shareholder.com. Archived from the original (PDF) on 17 July 2011. Retrieved 13 January 2022.{{cite web}}: CS1 maint: archived copy as title (link)

[1] "Emergent BioSolutions Completes Acquisition of Trubion Pharmaceuticals | Reuters". www.reuters.com. Archived from the original on 5 December 2014. Retrieved 13 January 2022.

[2] "Wyeth.com | CBD - Trubion Alliance". Archived from the original on 2008-08-28. Retrieved 2008-07-30.

[3] ttp://investors.trubion.com/releasedetail.cfm?ReleaseID=308846^{[permanent dead link‍]}

[trubion1-4] ttp://investors.trubion.com/releasedetail.cfm?ReleaseID=316893^{[permanent dead link‍]}

[5] "Archived copy" (PDF). files.shareholder.com. Archived from the original (PDF) on 17 July 2011. Retrieved 13 January 2022.{{cite web}}: CS1 maint: archived copy as title (link)

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