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TEKTIP1

TEKTIP1, also known as tektin-bundle interacting protein 1 is a protein that in humans is encoded by the TEKTIP1 gene.[1]

GeneCard for C19orf71


Gene

Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA.[1] The longest mRNA produced is 826 bases long.[2]

Aliases

Alias of the protein is C19orf71.[3] Locus

The TEKTIP1 gene is located at 19p13.3.[4]

Transcriptional Regulation

Several predicted transcription factors may bind in the promoter region:

ZSCAN4, POU2F3.[5][6][7][8][9][10][11]

Chemical Interactions

Acrylamide[12], cisplatin[13], and silicon dioxide[14] decrease expression, while butanal (butyraldehyde), and pentanal increase expression[15] of TEKTIP1 mRNA.

Sequence orthology also suggests that

valproic acid increases methylation of TEKTIP1 mRNA.[16]

Protein

The mRNA of TEKTIP1 is 654 nucleotides long.

molecular mass of 24.5 kDa.[3] The human protein has a theoretical isoelectric point of 9.1.[17]

Isoforms

There are two splice isoforms of the protein, X1[18] and X2[19].

X1 & X2 Isoform Orthologs
X1 X2
Tibetan macaque[20] Chimpanzee[21]
Olive baboon[22] Olive baboon[23]
Panamanian white-faced capuchin[24] Common marmoset[25]
Golden[26] and Black[27]

snub-nosed monkeys

Golden sub-nosed monkey[28]
Elk[29] Elk[30]
Red deer[31] Red deer[32]
Greater horseshoe bat[33] Bats[34][35][36]
Red fox[37] Polar bear[38]
File:TEKTIP1 structure (PHYRE2).png
Proposed tertiary structure for 27% of TEKTIP1. Image is in rainbow color, from the amino (N-terminus) to the carboxyl (C-terminus).[39]


Characteristics & structure

TEKTIP1 is highly enriched in tryptophan and tyrosine.[40] Additionally, the protein is semi-enriched in arginine and proline.[41]








Expression

TEKTIP1 is tissue specific and is found in higher levels in the

testis and thymus.[4]

In

fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20.[4]

TEKTIP1 protein is said to be specific to the

testis and is found in early spermatids during spermatogenesis.[42]

Evolution

Orthologs

File:TEKTIP1 Phylogenetic Tree.jpg
TEKTIP1 phylogenetic tree schematic. Line length between organisms represent degree of species divergence.[43]

Over 240 organisms have orthologs with human gene TEKTIP1.[4] The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA).[44][45]

Selected Orthologs for TEKTIP1
Genus and Species Common Name Taxonomic Group Median Date of Divergence (MYA) Accession # Sequence length (aa) Sequence Identity to Human Protein % Sequence Similarity to Human Protein %
Homo sapein
 		Human Primates/Hominidae 0 NP_001129052.1 209 100 100
Pan troglodyte
 		Chimpanzee Primates 6.4 XP_003316050.1 209 98.1 98.6
Mus musculus
 Mouse Rodentia 87 NP_001014836.2 217 45.6 60.4
Bos taurus
 		Cow Artiodactyla 94 NP_001070550 208 76.6 84.2
Panthera tigris
 		Tiger Carnivora 94 XP_042833719.1 210 34.1 38.9
Orcinus orca
 		Killer whale Cetacea 94 XP_012394771.2 216 63 73.1
Phascolarctos cinereus
 		Koala Diprodontia 160 XP_020824948.1 211 52.9 67.4
Haliaeetus leucocephalus
 		Bald Eagle Accipitiformes 319 XP_010580112.1 206 41.4 52
Dromaius novaehollandiae
 		Emu Aves 319 XP_025961204.1 190 44.8 56.7
Gallus gallus domesticus
 		Chicken Aves 319 XP_015155269.2 188 38.2 48.4
Crocodylus porosus
 		Saltwater Crocodile Crocodilia 319 XP_019406144.1 210 54.3 68.3
Caretta caretta
 		Loggerhead Sea Turtle Testudines 319 XP_048687032.1 216 47.8 57.3
Zootoca vivipara
 		Common lizard Squamata 319 XP_034975173.1 200 48.8 59.5
Crotalus tigris
 		Tiger Rattlesnake Squamata 319 XP_039190693.1 199 45.8 57.5
Protobothrops mucrosquamatus Venomous Pit Viper Squamata 319 XP_015665555.1 199 45.1 56.7
Bufo bufo
 		Common Toad Salientia 353 XP_040276375 136 24.7 34.3
Geotrypetes seraphini Gaboon Caecilian Caecilians 353 XP_033813379.1 156 36.1 45.8
Microcaecilia unicolor Tiny Caecilian Caecilians 353 XP_030074922.1 142 34.3 42.6
Protopterus annectens
 		West African Lungfish Actinopterygii 408 XP_043910031.1 142 28.6 39
  1. ^ a b c d "Homo sapiens tektin bundle interacting protein 1 (TEKTIP1), mRNA". 2022-08-14. {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ "PREDICTED: Homo sapiens tektin bundle interacting protein 1 (TEKTIP1), transcript variant X1, mRNA". 2022-04-05. {{cite journal}}: Cite journal requires |journal= (help)
  3. ^ a b c "tektin bundle interacting protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  4. ^ a b c d "TEKTIP1 tektin bundle interacting protein 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-12-14.
  5. PMID 20176812. {{cite journal}}: Check date values in: |date= (help
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  6. PMID 7739537. {{cite journal}}: Check date values in: |date= (help
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  7. PMID 8405995. {{cite journal}}: Check date values in: |date= (help
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  8. PMID 20176812. {{cite journal}}: Check date values in: |date= (help
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  9. PMID 7739537. {{cite journal}}: Check date values in: |date= (help
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  10. PMID 10473598.{{cite journal}}: CS1 maint: unflagged free DOI (link
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  11. PMID 29477841
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  12. PMID 32763439. {{cite journal}}: Check date values in: |date= (help
    )
  13. PMID 27392435
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  14. PMID 25895662.{{cite journal}}: CS1 maint: unflagged free DOI (link
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  15. PMID 26079696
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  16. PMID 29154799
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  17. ^ "Expasy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-12-14.
  18. ^ "uncharacterized protein C19orf71 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  19. ^ "uncharacterized protein C19orf71 isoform X2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  20. ^ "tektin bundle interacting protein 1 isoform X1 [Macaca thibetana thibe - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  21. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Pan troglodytes] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  22. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Papio anubis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  23. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Papio anubis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  24. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Cebus imitator] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  25. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Callithrix jacchu - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  26. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Rhinopithecus rox - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  27. ^ "PREDICTED: uncharacterized protein C19orf71 homolog isoform X1 [Rhinop - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  28. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Rhinopithecus rox - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  29. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Cervus canadensis - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  30. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Cervus canadensis - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  31. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Cervus elaphus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  32. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Cervus elaphus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  33. ^ "tektin bundle interacting protein 1 isoform X1 [Rhinolophus ferrumequi - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  34. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Myotis myotis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  35. ^ "PREDICTED: uncharacterized protein C19orf71 homolog [Myotis brandtii] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  36. ^ "tektin bundle interacting protein 1 isoform X2 [Rhinolophus ferrumequi - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  37. ^ "uncharacterized protein C19orf71 homolog isoform X1 [Vulpes vulpes] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  38. ^ "uncharacterized protein C19orf71 homolog isoform X2 [Ursus maritimus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  39. ^ Kelley, Lawrence. "PHYRE2 Protein Fold Recognition Server". www.sbg.bio.ic.ac.uk. Retrieved 2022-12-14.
  40. ^ Kelley, Lawrence. "PHYRE2 Protein Fold Recognition Server". www.sbg.bio.ic.ac.uk. Retrieved 2022-12-16.
  41. ^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-12-16.
  42. ^ "C19orf71 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2022-12-14.
  43. ^ "Phylogeny.fr: Home". www.phylogeny.fr. Retrieved 2022-12-15.
  44. ^ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2022-12-15.
  45. ^ "uncharacterized protein C19orf71 homolog [Protopterus annectens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-12-15.
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