Wen-Hsiung Li
Wen-Hsiung Li | |
|---|---|
| Born | Wen Hsiung Li September 22, 1942 University of Wisconsin-Madison |
| Thesis | Mathematical Studies On Mutational Damages In Finite Populations (1972) |
| Doctoral advisor | Wendell Fleming |
| Other academic advisors | Masatoshi Nei |
| Doctoral students | Brinda K. Rana |
| Website | Li Laboratory at University of Chicago Wen Hsiung Li Profile at Academia Sinica |
Wen-Hsiung Li (
James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan
.
Biography
Li was born in 1942 in Taiwan. In 1968 he received a M.S. in geophysics from
The University of Chicago
.
Scientific contributions
Li is best known for his studies on the molecular clock (i.e. rates and patterns of DNA sequence evolution[8]) and on the patterns and consequences of gene duplication.[9]
In 2003, he received the international
National Academy of Sciences, who cited his role in "establishing theoretical foundations for molecular phylogenetics and evolutionary genomics"[1]. He is the author of the first textbook in the field of molecular evolution, Molecular Evolution and Fundamentals of Molecular Evolution (co-authored with Dan Graur
), and an author on more than 200 peer-reviewed publications.
Honors
- Academician, Academia Sinica Taiwan, 1998
- Member, American Academy of Arts and Sciences, 1999
- President of the “Society for Molecular Biology and Evolution”, 2000
- Member, National Academy of Sciences, 2003
- Balzan prize 2003 for genetics and evolution (The third recipient, following Sewall Wright (1984) and John Maynard Smith(1991)).
- Inaugural Chen Award for Achievement in Human Genetic and Genomic Research, Human Genome Organisation, 2008
- 2019 SMBE Motoo Kimura Lifetime Contribution Award[10]
Selected publications
- Chu, T. -C.; Lu, C. -H.; Liu, T.; Lee, G. C.; Li, W. -H.; Shih, A. C. -C. (2013). "Assembler for de novo assembly of large genomes". Proceedings of the National Academy of Sciences. 110 (36): E3417–E3424. PMID 23966565.
- Gu, Z.; Steinmetz, L. M.; Gu, X.; Scharfe, C.; Davis, R. W.; Li, W. H. (2003). "Role of duplicate genes in genetic robustness against null mutations". Nature. 421 (6918): 63–6. S2CID 4348693.
- Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature. 416 (6881): 624–6. S2CID 4386652.
- Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature. 409 (6822): 847–9. PMID 11237007.
- Tan, Y.; Li, W. H. (1999). "Vision: Trichromatic vision in prosimians". Nature. 402 (6757): 36. PMID 10573416.
- Shyue, S.; Hewett-Emmett, D.; Sperling, H.; Hunt, D.; Bowmaker, J.; Mollon, J.; Li, W.H. (1995). "Adaptive evolution of color vision genes in higher primates". Science. 269 (5228): 1265–7. S2CID 25245772.
- Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature. 362 (6422): 745–7. S2CID 4345931.
- Graur, D.; Hide, W. A.; Li, W. H. (1991). "Is the guinea-pig a rodent?". Nature. 351 (6328): 649–52. S2CID 4344039.
- Graur, D. A. N.; Li, W.H. (1991). "Neutral mutation hypothesis test". Nature. 354 (6349): 114–6. S2CID 4267912.
- Wolfe, K. H.; Sharp, P. M.; Li, W. H. (1989). "Mutation rates differ among regions of the mammalian genome". Nature. 337 (6204): 283–5. S2CID 4336541.
- Gouy, M.; Li, W. H. (1989). "Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree". Nature. 339 (6220): 145–7. S2CID 4315004.
- Sharp, P.; Shields, D.; Wolfe, K.; Li, W.H. (1989). "Chromosomal location and evolutionary rate variation in enterobacterial genes". Science. 246 (4931): 808–10. PMID 2683084.
- Sharp, P. M.; Li, W.H. (1988). "Understanding the origins of AIDS viruses". Nature. 336 (6197): 315. PMID 3194016.
- Li, W. H.; Tanimura, M. (1987). "The molecular clock runs more slowly in man than in apes and monkeys". Nature. 326 (6108): 93–6. S2CID 4368098.
- Li, W. H.; Gojobori, T.; Nei, M. (1981). "Pseudogenes as a paradigm of neutral evolution". Nature. 292 (5820): 237–9. S2CID 23519275.
- Nei, M.; Li, W. H. (1979). "Mathematical model for studying genetic variation in terms of restriction endonucleases". Proceedings of the National Academy of Sciences. 76 (10): 5269–73. PMID 291943.
Selected books
- Li, W.-H. (2006). Molecular Evolution. Sinauer. ISBN 0-87893-480-4.
- Dan Graur; Wen-Hsiung Li (2000). Fundamentals of Molecular Evolution: Second Edition. Sinauer Associates, Inc. 1st edition. 1991.[11]
References
- ^ "Balzan Prize for Genetics and Evolution". International Balzan Prize Foundation website. International Balzan Prize Foundation. Retrieved February 8, 2014.
- ^ "Mendel Medal". The Genetics Society website. The Genetics Society. Retrieved February 8, 2014.
- S2CID 4345931.
- S2CID 4386652.
- ^ "Males' DNA propels evolution, study says". Chicago Tribune. 11 April 2002. Retrieved June 1, 2014.
- PMID 3983640.
- PMID 11237007.
- S2CID 4368098.
- S2CID 10823014.
- ^ "SMBE Motoo Kimura Lifetime Contribution Award". Society of Molecular Biology and Evolution. Retrieved April 12, 2019.
External links
- Official research profile
- Lab web site
- National Academy of Sciences citation
- Balzan Foundation profile
- Academia Sinica website reference for the HUGO/ "Chen Award" 2008
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