Y chromosome microdeletion

Y chromosome microdeletion (YCM) is a family of

The mechanism of mutation is not different for Y-chromosome microdeletion. However, the ability to repair it differs from other chromosomes. The human Y chromosome is passed directly from father to son, and is not protected against accumulating copying errors, whereas other chromosomes are error corrected by recombining genetic information from mother and father. This may leave natural selection as the primary repair mechanism for the Y chromosome.^{[citation needed]}

Diagnosis

Y chromosome microdeletion is currently diagnosed by extracting DNA from

Such procedures can test only the integrity of a tiny part of the overall 23 million base pair long Y chromosome. Therefore, the sensitivity of such tests depends on the choice and number of markers used. Present diagnostic techniques can only discover certain types of deletions and mutations on a chromosome and give therefore no complete picture of genetic causes of infertility. They can only demonstrate the presence of some defects, but not the absence of any possible genetic defect on the chromosome.^{[citation needed]}

The preferred test for genetic mutation, namely complete

• Infertility
• AZF1

References