Zeranol

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Zeranol
Clinical data
Trade namesFrideron, Ralabol, Ralgro, Ralone, Zerano
Other namesZearanol; α-Zearalanol; Zearalanol; MK-188; P-1496
Routes of
administration		By mouth
Drug classNonsteroidal estrogen
Identifiers
  • (3S,7R)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10,11,12-decahydro-1H-2-benzoxacyclotetradecin-1-one
JSmol)
  • C[C@H]1CCC[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1
  • InChI=1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1 ☒N
  • Key:DWTTZBARDOXEAM-GXTWGEPZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Zeranol (

anabolic agent in veterinary medicine.[1][2][3]

Zeranol is approved for use as a growth promoter in livestock, including beef cattle, under the brand name Ralgro (by

Merck Animal Health) in the United States.[4] In Canada, it is approved for use in beef cattle only.[5] Its application is not approved for use in the European Union. However, it is marketed under the brand name Ralone in Spain.[2]

Although zeranol may increase cancer cell proliferation in already existing breast cancer,[6] dietary exposure from the use of zeranol-containing implants in cattle is insignificant.[7] Zeranol may be found as a contaminant in fungus-infected crops. It is 3 to 4 times more potent as an estrogen than the related compound zearalenone.[8] It is a metabolite of zearalenone.[9]

See also

References

  1. ISBN 978-1-4757-2085-3
    .
  2. ^
    ISBN 978-3-88763-075-1
    .
  3. ISBN 978-94-011-4439-1
    .
  4. ^ Nichols W, Hutcheson J, Streeter M, Corrigan M, Nuttelman B. "Implant Strategies for Finishing Cattle using Revalor® (trenbolone acetate and estradiol), Finaplix® (trenbolone) and/or Ralgro® (zeranol)" (PDF).
  5. ^ Health Canada, Questions and Answers - Hormonal Growth Promoters
  6. PMID 20032412
    .
  7. PMID 2931335
    .
  8. PMID 161492
    .
  9. doi:10.1021/jf9601325
    .
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