AMN082
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| Names | |
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| IUPAC name
N,N′-Dibenzhydrylethane-1,2-diamine
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| Identifiers | |
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3D model (
JSmol ) |
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| ChemSpider | |
PubChem CID
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| Properties | |
| C28H28N2 | |
| Molar mass | 392.546 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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AMN082 (N,N′-dibenzhydrylethane-1,2-diamine) is a selective
glutamate. AMN082 is the first selective mGluR7 agonist
and has expanded the potential array of research opportunities on the effects of mGluR7 in the central nervous system.
Significance
The two main types of
G-protein coupled receptors
that mediate slower, longer-lasting effects through second messenger systems and are responsible for other neuronal functions that are not typically controlled by iGluRs. mGluRs are split into 3 separate groups (Group I, Group II, Group III) based on pharmacological profile, sequence homology, and preferred signal transduction pathway. mGlur7 is a member of Group III, the least studied of the groups. AMN082 is pharmacological tool used to expand research on Group III mGluRs.