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PHCCC
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Српски / srpski
Srpskohrvatski / српскохрватски
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Source: Wikipedia, the free encyclopedia.
Chemical compound
PHCCC
Identifiers
IUPAC name
(−)-N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
JSmol)
Interactive image
SMILES
c4ccccc4NC(=O)C1(CC1C2=NO)Oc3ccccc23
(verify)
PHCCC
is a research drug which acts as a
positive allosteric modulator at the
mGluR
4
subtype,
[1]
as well as an agonist at
mGluR
6
.
[2]
It has anxiolytic effects in animal studies.
[3]
PHCCC and similar drugs have been suggested as novel treatments for
Parkinson's disease
.
[4]
See also
CPCCOEt
References
S2CID
17446511
.
PMID
18593581
.
PMID
15363989
.
PMID
18664603
.
v
t
e
Metabotropic glutamate receptor
modulators
Group I
mGluR
1
Tooltip Metabotropic glutamate receptor 1
Agonists:
ACPD
DHPG
Glutamate
Ibotenic acid
Quisqualic acid
Ro01-6128
Ro67-4853
Ro67-7476
VU-71
Theanine
Antagonists:
BAY 36-7620
CPCCOEt
Cyclothiazide
LY-367,385
LY-456,236
MCPG
NPS-2390
mGluR
5
Tooltip Metabotropic glutamate receptor 5
Agonists:
ACPD
ADX-47273
CDPPB
CHPG
DFB
DHPG
Glutamate
Ibotenic acid
Quisqualic acid
VU-1545
Antagonists:
CTEP
DMeOB
LY-344,545
Mavoglurant
MCPG
NPS-2390
Remeglurant
SIB-1757
SIB-1893
;
Negative allosteric modulators:
AZD9272
Basimglurant
Dipraglurant
Fenobam
GRN-529
MPEP
MTEP
Raseglurant
Group II
mGluR
2
Tooltip Metabotropic glutamate receptor 2
Agonists:
BINA
CBiPES
DCG-IV
Eglumegad
Glutamate
Ibotenic acid
LY-379,268
LY-404,039 (pomaglumetad)
LY-487,379
LY-566,332
MGS-0028
Pomaglumetad methionil (LY-2140023)
JNJ-40411813 (ADX-71149)
Antagonists:
APICA
CECXG
EGLU
HYDIA
LY-307,452
LY-341,495
MCPG
MGS-0039
PCCG-4
;
Negative allosteric modulators:
Decoglurant
RO4491533
mGluR
3
Tooltip Metabotropic glutamate receptor 3
Agonists:
CBiPES
DCG-IV
Eglumegad
Glutamate
Ibotenic acid
LY-379,268
LY-404,039 (pomaglumetad)
LY-487,379
MGS-0028
Pomaglumetad methionil (LY-2140023)
Talaglumetad
Antagonists:
APICA
CECXG
EGLU
HYDIA
LY-307,452
LY-341,495
MCPG
MGS-0039
;
Negative allosteric modulators:
Decoglurant
RO4491533
Group III
mGluR
4
Tooltip Metabotropic glutamate receptor 4
Agonists:
Glutamate
L
-AP4
LSP2-9166
PHCCC
VU-001,171
VU-0155,041
;
Positive allosteric modulators:
Foliglurax
MPEP
Antagonists:
CPPG
MAP4
MPPG
MSOP
MTPG
UBP-1112
mGluR
6
Tooltip Metabotropic glutamate receptor 6
Agonists:
Glutamate
L
-AP4
Antagonists:
CPPG
MAP4
MPPG
MSOP
MTPG
UBP-1112
mGluR
7
Tooltip Metabotropic glutamate receptor 7
Agonists:
AMN082
Glutamate
L
-AP4
LSP2-9166
Antagonists:
CPPG
MAP4
MMPIP
MPPG
MSOP
MTPG
UBP-1112
XAP044
;
Negative allosteric modulators:
ADX71743
mGluR
8
Tooltip Metabotropic glutamate receptor 8
Agonists:
DCPG
Glutamate
L
-AP4
;
Positive allosteric modulators:
AZ12216052
Antagonists:
CPPG
MAP4
MPPG
MSOP
MTPG
UBP-1112
See also:
Receptor/signaling modulators
•
Ionotropic glutamate receptor modulators
•
Glutamate metabolism/transport modulators
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