Cyclothiazide

Source: Wikipedia, the free encyclopedia.
Cyclothiazide
Clinical data
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-(bicyclo[2.2.1]hept-5-en-2-yl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
JSmol)
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NC(N2)C4[C@@H]3\C=C/[C@@H](C3)C4)N
  • InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1 ☒N
  • Key:BOCUKUHCLICSIY-QJWLJZLASA-N ☒N
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Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran), sometimes abbreviated CTZ, is a

antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan.[1][2] Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide.[3]

In 1993, it was discovered that cyclothiazide is a

epileptiform activity and inducing seizures, but without producing any apparent neuronal death.[8][9]

Cyclothiazide has been found to act as a

mGluR1.[10] It is selective for mGluR1 over other metabotropic glutamate receptors.[10]

Synthesis

Cyclothiazide synthesis:[11][12]

See also

References

  1. ISBN 978-3-88763-075-1
    .
  2. ISBN 978-0-8155-1144-1
    .
  3. ^
    ISBN 978-0-8493-8307-6
    .
  4. PMID 8103555
    .
  5. PMID 7915948
    .
  6. ISBN 978-3-540-22568-3
    .
  7. PMID 14534329
    .
  8. PMID 16423850
    .
  9. PMID 20678492
    .
  10. ^
    PMID 17095021
    .
  11. doi:10.1021/jo01066a046
    .
  12. ^ US 3275625, Müller E, Hasspacher K, issued 1966, assigned to Boehringer Ingelheim