Metabotropic glutamate receptor 8
Appearance
GRM8 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 7: 126.44 – 127.25 Mb | Chr 6: 27.28 – 28.14 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.[5][6]
Function
splice variants of GRM8 have been described but their full-length nature has not been determined.[6]
Ligands
- (S)-3,4-DCPG: agonist[7]
- AZ12216052: positive allosteric modulator[8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179603 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024211 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8824806.
- ^ a b "Entrez Gene: GRM8 glutamate receptor, metabotropic 8".
- S2CID 2872874.
- PMID 20385173.
Further reading
- Scherer SW, Soder S, Duvoisin RM, Huizenga JJ, Tsui LC (September 1997). "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1". Genomics. 44 (2): 232–236. PMID 9299241.
- Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, et al. (January 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Research. Molecular Brain Research. 53 (1–2): 88–97. PMID 9473604.
- Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RL, Mutel V (April 1999). "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8". Brain Research. Molecular Brain Research. 67 (2): 201–210. PMID 10216218.
- Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (March 2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology. 40 (3): 311–318. S2CID 2872874.
- Enz R (March 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Letters. 514 (2–3): 184–188. S2CID 44474808.
- Tang Z, El Far O, Betz H, Scheschonka A (November 2005). "Pias1 interaction and sumoylation of metabotropic glutamate receptor 8". The Journal of Biological Chemistry. 280 (46): 38153–38159. PMID 16144832.
- Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, et al. (February 2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatric Genetics. 17 (1): 9. PMID 17167337.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.