Acute eosinophilic leukemia
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (June 2014) |
| Acute eosinophilic leukemia | |
|---|---|
| Specialty | Hematology, oncology |
Acute eosinophilic leukemia (AEL) is a rare subtype of
are more common than in other variants of AML.Diagnosis
A specific histochemical reaction, cyanide-resistant peroxidase, permits identification of leukemic blast cells with eosinophilic differentiation and diagnosis of acute eosinoblastic leukemia in some cases of AML with few identifiable eosinophils in blood or marrow.
Treatment and prognosis
When there is eosinophilia with increased immature precursors along with blasts; one need to identify lineage of blasts. As per old FAB classification most of the time blast lineage will be myeloid and may fall in M4EO of FAB classification.[3] This entity need treatment like acute myeloid leukemia. However more rarely Eosinophilic leukemia may have underlying lymphoid blasts with t(5;14) (IL3;IGH).[4] with this gene fusion and eosinophilic cytokine comes under control of immunoglobulin heavy chain (IgH) locus. This entity need treatment as ALL. Overall prognosis is not dependent on eosinophilia but underlying lineage and genetic abnormalities.
References
- PMID 25858537.
- PMID 27166925.
- ^ "Acute Myeloid Leukemia (AML) Subtypes and Prognostic Factors". www.cancer.org. Retrieved 2022-02-03.
- PMID 31921638.
External links
 | This oncology article is a stub. You can help Wikipedia by expanding it. |