Minimally differentiated acute myeloblastic leukemia
| Minimally differentiated acute myeloblastic leukemia | |
|---|---|
.jpg) | |
| The appearance of acute myeloblastic leukemia, M0 under microscope. Blasts show no Auer rods. | |
| Specialty | Hematology, oncology |
Minimally differentiated acute myeloblastic leukemia is a subtype of AML. It is classified as M0 by FAB. It represents 2–3% of all cases of AML.[1] Although minimally differentiated AML was recognized earlier, criteria for FAB M0 were developed in 1987.[2] The blasts in these cases cannot be recognized as myeloid based on morphology and cytochemistry, but immunophenotyping demonstrates myeloid antigens.[3]
Cytochemistry and molecular features
In acute myeloblastic leukemia (M0), the blasts are agranular and nonreactive when stained for
CD13, CD33, and CD34. Human leukocyte antigen (HLA)-DR is positive in most patients. Occasional cases require in situ hybridization to identify the myeloperoxidase gene315 or genomic profiling for early myeloid-associated genes.[4] Abnormal and unfavorable karyotypes (e.g., loss of the long arm of chromosome 5 (5q-) and 7q-) and higher expression of the multidrug resistance glycoprotein (p170) are frequent.[5] In general, minimally differentiated acute myeloblastic leukemia has a poor prognosis.[6]
See also
- Acute myeloid leukemia
- FAB) — M9873/3
- FAB) — M9874/3
References
- ^ Kumar V, Abbas AK, Fausto N, Mitchel RN (2007). Robbins basic Pathology (8th ed.). Saunders.
- PMID 3663939.
- ^ Greer JP, Foerster J, Lukens JN (2003). Wintrobe's Clinical Hematology (11th ed.). Lippincott Williams & Wilkins.
- PMID 12036900.
- ^ Lichtman M, et al. (2005). Williams Hematology (7th ed.). McGraw-Hill.
- PMID 7780152.