Anthony Cashmore

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Anthony R. Cashmore
Plant biology
Molecular biology
InstitutionsUniversity of Pennsylvania (Professor Emeritus)
Rockefeller University
(Associate Professor)
Websitelive-sas-bio.pantheon.sas.upenn.edu/people/anthony-cashmore

Anthony R. Cashmore (b. 22 Jan 1941)

molecular biologist, best known for identifying cryptochrome photoreceptor proteins.[1][3][4][5] These specialized proteins are critical for plant development and play an essential role in circadian rhythms of plants and animals.[4][5][6][7] A Professor emeritus in the Department of Biology at the University of Pennsylvania, Cashmore led the Plant Science Institute from the time of his appointment in 1986 until his retirement in 2011.[8] He was elected to the National Academy of Sciences in 2003.[9]

Early life and education

Born in Auckland (New Zealand) in 1941, Cashmore grew up in Manawaru and Te Aroha. As a teenager, Cashmore worked in Palmerston North in the Grasslands Division of New Zealand's Department of Scientific and Industrial Research (DSIR).[10]

Cashmore enrolled at the

Research Associate in the laboratory of Michael Chamberlin at the University of California, Berkeley before returning to New Zealand.[2][9]

In 1979, Cashmore took a position at the Rockefeller University (New York), first as a visiting scientist in the laboratory of Nam-Hai Chua, and then as an assistant professor, then Associate Professor.[11] In 1986, Cashmore was appointed the Director of the Plant Science Institute at the University of Pennsylvania (Philadelphia).[4][2] He retired in 2011 and is currently an Emeritus Professor of Biology at the University of Pennsylvania.[8]

Career

Prostratin

During his

co-carcinogenic phorbol esters of croton oil, a relationship that was subsequently confirmed using chemical synthesis[12] and x-ray crystallography approaches.[13]

Nucleic acid chemistry

Hydrazine degradation

Working with George Petersen (a New Zealand biochemist) at New Zealand's Department of Scientific and Industrial Research (DSIR) (Palmerston North), Cashmore was introduced to the study of nucleic acids and how selective chemical reagents could be used to determine the nucleic acid sequence of DNA.[10] Cashmore and Petersen examined the use of hydrazine as a tool to measure purine nucleotides in samples of DNA.[14][15] Recognizing that hydrazine-treated DNA subsequently exposed to alkali conditions undergoes degradation, Cashmore defined a quantitative technique for measuring purine nucleotides in DNA samples.[14] Subsequently, Allan Maxam and Walter Gilbert employed the hydrazine degradation approach to develop Maxam–Gilbert sequencing, the first widely adopted method for DNA sequencing.[16]

tRNA

Working with Dan Brown

Fred Sanger to identify the reactive cytosine residues in a tyrosine suppressor tRNA of Escherichia coli.[18] Studying a mutant of this tRNA, Cashmore identified a new reactive cytosine residue at the base of loop III.[19] This finding suggested that base pairing of conserved residues occurred supporting one of the early models proposed for the three dimensional structure of transfer RNA.[20]

Biosynthesis of RuBisCO

inhibitors of protein synthesis Cashmore showed that in contrast to the RuBisCO large subunit (which was known to be synthesized on chloroplast ribosomes), the small subunit of RuBisCO was produced as a soluble precursor protein on cytoplasmic ribosomes.[25] The soluble precursor protein is subsequently processed and imported into chloroplasts.[26][27]

Light-regulated enhancer sequences

At Rockefeller University, Cashmore studied DNA sequences associated with light regulated expression of a pea nuclear RuBisCO small subunit gene.[28] For these studies, Cashmore collaborated with scientists in the laboratory of Jeff Schell and Marc Van Montagu in Ghent (Belgium).[29] Using transgenic plant cells, they demonstrated that in the pea plant, light-regulated expression was mediated by a 1 kilobase (kb) promoter fragment.[28] In a second study, this DNA fragment was shown to have the properties of an enhancer sequence, functioning in either orientation and when fused to a normally non-light-regulated promoter.[30]

Cryptochrome

In 1881, Francis Darwin and Charles Darwin demonstrated that plants exhibited a phototropic response to blue light.[31][32][33] Elusive to discovery, scientists gave the name cryptochrome to the photoreceptor factor(s) responsible for this effect.[34] Interested in adopting the "power of Arabidopsis genetics" for the study of light regulation,[7] in 1980 Cashmore, working with post-doctoral student Margaret Ahmad, identified Arabidopsis mutants that showed reduced sensitivity to blue light. Using DNA sequencing and complementation techniques, Cashmore and Ahmed cloned the gene and discovered that the mutants were alleles of a previously identified hy4 mutant.[5] Ahmad and Cashmore called this blue light photoreceptor "cryptochrome", and it is now referred to as CRY1.[5][35] Cashmore's research group identified a second member of the cryptochrome family (CRY2) using cDNA library screening.[4] This research was the foundation that led to the identification of CRY proteins in other plant species, bacteria, fungi, animals, and humans, as well as research that defined the pivotal role of these proteins in circadian clock regulation across species[7][36] and as the primary sensory molecule enabling light-dependent magnetic compass orientation in migratory birds.[37] Today, light-based diagnostic and therapeutic wearable photonic healthcare devices, are based on the function of the cryptochrome photoreceptors.[38]

Human behavior, free will and consciousness

In recent years, Cashmore turned his attention to the topic of human behavior, studying the concepts of

nature vs nurture, an element that is commonly missing is awareness that individuals are responsible for neither their genetic inheritance nor their environment.[39] Based on this observation, he therefore asked "where does this notion of free will come from?" and challenged the scientific community to reconsider the concept of free will.[39][40]

Applying the

behavioral sciences, and philosophy.[43] Scientist and author Jerry Coyne stated that after reading this article on determinism and the criminal justice system, he was ‘instantly converted to determinism’.[44][45][46]

Honors and awards

Cashmore was a Professor of Biology at the University of Pennsylvania and Director of the Plant Science Institute there until his retirement in 2011.[9] Since 2011, he has been a Professor emeritus at the University of Pennsylvania (Department of Biology).[9] Cashmore has authored more than 100 refereed research papers and has served on the editorial boards of the publications Plant Molecular Biology, The Plant Journal, and the Proceedings of the National Academy of Sciences of the United States of America.[9][47] He was elected to the National Academy of Sciences in 2003.[9][48]

Selected publications

Journal articles

Patents

Book chapters

  • Jarillo J, Capel J, and Cashmore AR (2004) Chapter 8: Physiological and molecular characteristics of plant circadian clocks, in Molecular Biology of Circadian Rhythms[49]

Personal life

Cashmore was born in Auckland (New Zealand), to parents Nancy and Norman Cashmore.[50] He is married to American Neuroscientist and Geneticist Nancy Bonini.[51]

References

  1. ^ a b "It's About Time: Biological Clock Research Keeps Ticking". eurekalaert.org. American Association for the Advancement of Science. 23 Dec 1998. Archived from the original on 21 May 2005. Retrieved 10 Jan 2020.
  2. ^ a b c d e "Curriculum Vitae, ANTHONY R. CASHMORE" (PDF). upenn.edu. University of Pennsylvania. 2019. Retrieved 13 Nov 2019.
  3. ISBN 978-1-4615-5051-8
    . Retrieved 23 January 2020.
  4. ^
    PMID 9482948
    .
  5. ^
    S2CID 4256360
    . Retrieved 25 Jan 2020.
  6. ISBN 978-0-470-99429-0
    . Retrieved 8 April 2021.
  7. ^ a b c Miller, Susan Katz (20 Nov 1993). "Science: Darwin's plants give up their 'blue' secrets". New Scientist. Retrieved 8 Apr 2021.
  8. ^ a b "Retired/Emeritus Faculty". Penn Arts & Sciences Department of Biology. The Trustees of the University of Pennsylvania. 2020. Retrieved 4 Jan 2020.
  9. ^ a b c d e f g "Plant Biologist Anthony Cashmore Elected to National Academy of Sciences". penntoday.upenn.edu. University of Pennsylvania. 5 May 2003. Retrieved 13 Nov 2019.
  10. ^
    PMID 21191100
    .
  11. ^ "Plant Biology Tree: Anthony Robert Cashmore". The Academic Family Tree. 2021. Retrieved 13 Mar 2021.
  12. doi:10.1016/S0040-4039(00)92940-X
    . Retrieved 8 Apr 2021.
  13. doi:10.1016/S0040-4039(00)92939-3
    . Retrieved 7 Jul 2021.
  14. ^
    PMID 4888872
    . Retrieved 28 Jan 2020.
  15. PMID 353742
    .
  16. PMID 265521
    .
  17. S2CID 81639128
    .
  18. PMID 4935788
    . Retrieved 15 Mar 2021.
  19. PMID 5280403
    . Retrieved 10 Jul 2021.
  20. S2CID 983981
    . Retrieved 10 Jul 2021.
  21. PMID 30782794
    .
  22. PMID 265554
    .
  23. ^ Cohen, Mati. "Will Rubisco stop global warming?". www.economarks.com. Economarks. Retrieved 13 Nov 2021.
  24. PMID 1262350
    . Retrieved 19 Jan 2020.
  25. PMID 16592495
    . Retrieved 21 Jul 2021.
  26. S2CID 4188202
    . Retrieved 28 Nov 2021.
  27. S2CID 922287
    . Retrieved 28 Nov 2021.
  28. ^
    S2CID 4307727
    . Retrieved 26 Nov 2021.
  29. PMID 31883186
    .
  30. S2CID 4307881
    . Retrieved 15 Dec 2019.
  31. ^ Miller, Susan Katz (20 Nov 1993). "Science: Darwin's plants give up their 'blue' secrets". New Scientist. Retrieved 8 Dec 2019.
  32. S2CID 42260720
    . Retrieved 5 Jan 2020.
  33. ^ Darwin, Charles (1881). The Power of Movement in Plants. New York: D. Appleton and Company.
  34. S2CID 98643540
    . Retrieved 28 Nov 2021.
  35. S2CID 40649563
    . Retrieved 30 Dec 2021.
  36. ^ Hall, Jeffrey; Rosbach, Michael; Young, Michael (2017). "Scientific Background Discoveries of Molecular Mechanisms Controlling the Circadian Rhythm". nobelprize.org. Nobel Prize Outreach. Retrieved 10 Dec 2021.
  37. PMID 32978454
    .
  38. PMID 32728478
    .
  39. ^
    PMID 20142481
    .
  40. ^ "Anthony Cashmore". informationphilosopher.com. Bob Doyle. Retrieved 28 Jan 2020.
  41. ISBN 978-0-7391-7732-7
    . Retrieved 28 January 2020.
  42. ^ Butt, Kyle (29 Oct 2020). "Atheism & Free Will". mathetis. Retrieved 1 Apr 2021.
  43. ISBN 978-0-19-959542-6
    . Retrieved 28 January 2020.
  44. ^ Harris, Lee (2018). "Meet Jerry Coyne, the University's Most Prolific and Provocative Emeritus Blogger". The Chicago Maroon. Chicago, USA. Archived from the original on 16 November 2018. Retrieved 30 Dec 2019.
  45. ISBN 978-0-19-937164-8
    . Retrieved 5 Jan 2020.
  46. ^ Zyga, Lisa (2010). "Free will is an illusion, biologist says". phys.org. Science X. Retrieved 20 Dec 2019.
  47. ^ "About the PNAS Member Editor: Anthony Cashmore". National Academy of Sciences. National Academy of Sciences. 2021. Retrieved 22 Dec 2021.
  48. ^ "Member Directory: Anthony Cashmore". National Academy of Sciences. National Academy of Sciences. 2021. Retrieved 8 Apr 2021.http://www.nasonline.org/member-directory/members/20002156.html
  49. ISBN 978-0-471-41824-5
    . Retrieved 13 November 2019.
  50. ^ "Town Topics". geneanet.org. Geneanet. 2019. Retrieved 13 Nov 2019.
  51. ^ Kelly, Morgan (3 Jan 2017). "Geoscientist William Bonini, dedicated teacher and genial colleague, dies at 90". Princeton University News. Princeton, NJ, USA. Retrieved 12 Jul 2019.

External links

• Google Scholar - Anthony R. Cashmore

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