Bordetella

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Bordetella
Flagellated "Bordetella bronchiseptica"
Flagellated Bordetella bronchiseptica
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
Moreno-López 1952
Species[2]

Bordetella (

coccobacilli bacteria of the phylum Pseudomonadota. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described (B. pertussis, B. parapertussis, B. bronchiseptica); are sometimes referred to as the 'classical species'. Two of these (B. pertussis and B. bronchiseptica) are also motile.[3][4]

There are about 16 different species of Bordetella likely descending from ancestors who lived in soil and/or water environments.

pertussis (whooping cough) in humans, and some B. parapertussis strains only colonize sheep.[5] It has also been known to cause bronchitis in cats and bronchopneumonia in pigs.[5]

B. bronchiseptica rarely infects healthy humans, though disease in

atrophic rhinitis in pigs. Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium
).

The genus Bordetella is named after Jules Bordet.

Pathogenesis

The three most common species of Bordetella are B. pertussis, B. parapertussis and B. bronchiseptica. These species are known to accumulate in the respiratory tracts of mammals. This is most commonly seen in human infants as a product of an illness known as whooping cough. The particular species responsible for this illness is B. pertussis, and can only be found in humans. Even with extensive vaccination research on B. pertussis, whooping cough is still considered endemic in many countries. Due to the fact B. pertussis is only found in humans and shows little genetic variation from the other Bordetella species, it is thought that it was derived from a common ancestor in recent years.

B. parapertussis can affect both humans and other mammals, primarily sheep. Similar to B. pertussis, it causes whooping cough in babies. Yet, when strains found in sheep are isolated there is a strong distinction between those found in humans. This suggests that the varying strains of this species evolved independently of one another, the one found in humans and the one found in sheep. With this particular distinction it means that there is little to no transmission between the two reservoirs.

The species B. bronchiseptica (gram-negative, aerobic) however has a broader host range, causing similar symptoms in a wide range of animals, while only occasionally affecting humans. These symptoms often manifest as chronic and

peritrichous flagella that enables it to be motile. On a petri dish, colonies of this species appear small, grayish-white, smooth, and shiny. This species is also typically associated with kennel cough (Canine Respiratory Infectious Disease (CRID)) in dogs.[7][8]

Molecular structure of pertussis toxin complex (protein) highlighting alpha helices and beta pleated sheets. Also including the 5 different sub-units.

The most thoroughly studied of the Bordetella species are B. bronchiseptica, B. pertussis and B. parapertussis, and the pathogenesis of respiratory disease caused by these bacteria has been reviewed.

fimbriae, and pertussis toxin (though expression of pertussis toxin is unique to B. pertussis). As well as assisting in adherence to epithelial cells, some of these are also involved in attachment to immune effector cells
.

The initial

cyclic AMP. Recently discovered activities of adenylate cyclase toxin, including transmembrane pore formation and stimulation of calcium influx
, may also contribute to the intoxication of phagocytes.

Virulence factors

The virulence factors identified in the Bordetella are common to all three species. These include

dermonecrotic toxin and tracheal cytotoxin. These factors are then expressed and regulated most often by environmental stimuli. Differences in virulence factors relate to the loss of regulatory or control functions. Bordetella sp. is typically found to live within the hosts' respiratory tract and immune system and can transmit to new hosts.[5] Bordetella pertussis also affects human adults and even with an 85% vaccination coverage over 160,000 related deaths occur each year all around the globe.[5] There are few antimicrobial susceptibility testing methods but no change or progress have been discovered as of 2018.[5]
Most studies performed using Bordetella vaccines have many flaws and fail to come to an official conclusion.

Regulation of virulence factor expression

The expression of many Bordetella adhesins and toxins is controlled by the two-component regulatory system BvgAS.[10][11] Much of what is known about this regulatory system is based on work with B. bronchiseptica, but BvgAS is present in B. pertussis, B. parapertussis and B. bronchiseptica and is responsible for phase variation or phenotypic modulation.

BvgS is a

plasma membrane-bound sensor kinase which responds to stimulation by phosphorylating a cytoplasmic helix-turn-helix-containing protein, BvgA. When phosphorylated, BvgA has increased affinity for specific binding sites in Bvg-activated promoter sequences and is able to promote transcription in in vitro assays.[13][14]

Most of the toxins and adhesins under BvgAS control are expressed under Bvg+ conditions (high BvgA-Pi concentration). But there are also genes expressed solely in the Bvg− state, most notably the

coding sequences of at least some Bvg-repressed genes. Binding of this protein to the consensus sequence represents gene expression by reducing transcription.[17]

It is not known what the physiological signals for BvgS are, but

nicotinic acid, or by reduction of the incubation temperature to ≤ 26 °C.[18][19]

The identification of a specific point mutation in the BvgS gene which locks B. bronchiseptica in an intermediate Bvg phase revealed a class of BvgAS-regulated genes that are exclusively transcribed under intermediate concentrations of BvgA-Pi. This intermediate (Bvgi) phenotype can be reproduced in wild-type B. bronchiseptica by growth of the bacteria in a medium containing intermediate concentrations of the BvgAS modulator,

nicotinic acid. In these conditions, some, but not all of the virulence factors associated with the Bvg+ phase are expressed, suggesting this two-component regulatory system can give rise to a continuum of phenotypic states in response to the environment.[18]

Vaccines

The Bordetella vaccine is non-essential, but highly recommended for dogs especially if they are expected to come into contact with other dogs at dog parks, boarding facilities, dog shows, training classes, etc.[20] In fact, it can be required at certain facilities for entry. The vaccine can also be given to cats, but it is less commonly done because infection appears to be uncommon in adult cats. However, it may be a good idea to vaccinate a kitten if it is in a high-risk environment (i.e. living with multiple other cats).[21]

The Bordetella vaccine specifically targets Bordetella bronchiseptica, the species typically responsible for kennel cough. The vaccine introduces the bacteria (live or dead) to the body in order to develop an

parainfluenza virus, even after being vaccinated for B. bronchiseptica.[20] The Bordetella vaccine is also only about 70% effective.[22]

There are three licensed ways to deliver the Bordetella vaccine to dogs: orally,

control group. After 42 days, the dogs were exposed to Bordetella bronchiseptica. This study determined that the live intranasal Bordetella vaccine was more effective than the killed subcutaneous vaccine, and the live oral vaccine works equally as well as the live intranasal vaccine.[23]

References

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  2. ^ "Bordetella". NCBI taxonomy. Bethesda, MD: National Center for Biotechnology Information. Retrieved 16 January 2019.
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    ISBN 978-0-12-304220-0. {{cite book}}: |journal= ignored (help
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  11. ^
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  12. S2CID 22884606
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  14. PMID 8598192
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  16. PMID 7751282
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  18. ^
    S2CID 285961
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  19. PMID 9513272
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  20. ^ a b Burke A (May 26, 2017). "5 Facts About the Bordetella Vaccine for Dogs". American Kennel Club. Retrieved 2023-04-21.
  21. ^ Gardiner J (2019-03-27). "Vaccination Guidelines for Dogs and Cats". Animal Health Topics / School of Veterinary Medicine. Retrieved 2023-04-21.
  22. ^ "How Bordetella Vaccines Work". HowStuffWorks. 2009-01-23. Retrieved 2023-04-21.
  23. ^ Larson, Laurie & Thiel, Bliss & Sharp, Patricia & Schultz, Ronald. (2013). A Comparative Study of Protective Immunity Provided by Oral, Intranasal and Parenteral Canine Bordetella bronchiseptica Vaccines. International Journal of Applied Research in Veterinary Medicine. 11. 153-160.

[1] [2] [3] [4] [5]

  1. ^ Bryant, C. (2009, January 23). How Bordetella Vaccines Work. Retrieved November 18, 2020, from https://animals.howstuffworks.com/pets/pet-travel/bordetella-vaccine1.htm.
  2. ^ Burke, A. (2018, July 13). 5 Facts About the Bordetella Vaccine for Dogs. Retrieved October 22, 2020, from https://www.akc.org/expert-advice/health/facts-bordetella-vaccine-dogs/
  3. ^ Gardiner, J. (2020, August 11). Vaccination Guidelines for Dogs and Cats. Retrieved November 18, 2020, from https://healthtopics.vetmed.ucdavis.edu/health-topics/feline/vaccination-guidelines-dogs-and-cats
  4. ^ Kadlec, K., & Schwarz, S. (2018). Antimicrobial Resistance in Bordetella bronchiseptica (1062719807 809797198 L. Cavaco & 1062719808 809797198 J. Shen, Eds.). Antimicrobial Resistance in Bacteria from Livestock and Companion Animals, 365-375. doi:10.1128/9781555819804.ch16
  5. ^ Larson, Laurie & Thiel, Bliss & Sharp, Patricia & Schultz, Ronald. (2013). A Comparative Study of Protective Immunity Provided by Oral, Intranasal and Parenteral Canine Bordetella bronchiseptica Vaccines. International Journal of Applied Research in Veterinary Medicine. 11. 153-16
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