C5orf22
C5orf22 | ||||||
---|---|---|---|---|---|---|
Identifiers | ||||||
Ensembl | ||||||
UniProt | ||||||
RefSeq (mRNA) | ||||||
RefSeq (protein) | ||||||
Location (UCSC) | Chr 5: 31.53 – 31.56 Mb | Chr 15: 12.81 – 12.82 Mb | ||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Chromosome 5
Gene
C5orf22 is located on the
Expression and regulation
C5orf22 displays ubiquitous
C5orf22 contains 1 predicted
Neighboring elements
C5orf22 closest neighboring element is
Structure
C5orf22 contains 2 globular domains and 3 small disordered regions.
Subcellular distribution
C5orf22 is most likely to exist as a
Function
The precise function of C5orf22 is still unknown however it is hypothesized to be a component of a DNA splicing complex.[18] Proteomic research implicated the protein product as a novel component of the WBP11/PQBP1 splicing complex which regulates expression of genes involved in a spectrum of processes ranging from DNA repair to immunomodulation.[18] C5orf22 knockdown was associated with downregulation of alternative splicing events that led to aberrant gene expression of select genes and ultimately cell cycle dysfunction.[18] Cell localization evidence and the presence of a NLS further support this hypothesized function.
Interacting proteins
Experimental evidence has indicated over 20 interactors with C5orf22. [19][20][21] Interactants are localized to both the nucleus and cytoplasm.[22] The most likely interactors are WBP11, OSM, Surf2, ELOF1, and DDITL4.[20]
Evolution & homology
C5orf22 initially appeared in
UPF0489 C5orf22 is slow
Taxonomic Class
|
Common Name | Genus species | Date of Divergence
Millions of Years Ago (MYA) |
Sequence
Identity (%) |
Sequence
Similarity (%) |
Sequence
Length (AA) |
Query Coverage
(%) |
Accession Number |
---|---|---|---|---|---|---|---|---|
Mammal | Human | Homo sapiens | N/A | 100 | 100 | 442 | 100 | NP_060826.2 |
Mouse | Mus musculus | 90 | 78 | 86 | 442 | 100 | NP_084274.1 | |
Whale | Balaenoptera musculus | 96 | 89 | 94 | 467 | 100 | XP_036705025.1 | |
Aves
|
Chicken | Gallus gallus | 312 | 68 | 79 | 446 | 98 | XP_418996.3 |
Reptile | Tiger rattlesnake | Crotalus tigris | 312 | 65 | 75 | 476 | 98 | XP_039212189.1 |
Amphibian | African clawed frog | Xenopus laevis | 352 | 67 | 78 | 459 | 95 | XP_018121838.1 |
Fish | Zebrafish | Danio rerio | 435 | 57 | 71 | 439 | 95 | NP_956625.1 |
Sea lamprey | Petromyzon marinus | 615 | 51 | 69 | 589 | 89 | XP_032827184.1 | |
Invertebrate | Fruit fly | Drosophila suzukii | 797 | 33 | 50 | 481 | 95 | XP_036671373.1 |
Clinical significance
Recent studies on miRNA's role in breast cancer pathogenesis has correlated upregulation of C5orf22 with reduced survival of breast cancer patients.[26]
Patient's with
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000082213 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022195 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e f g "C5orf22 chromosome 5 open reading frame 22 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-18.
- ^ "Human C5orf22". www.genecards.org. Archived from the original on 2011-11-26. Retrieved 2021-09-20.
- ^ "Transcript: ENST00000325366.14 (C5orf22-201) - Summary - Homo_sapiens - Ensembl genome browser 105". useast.ensembl.org. Retrieved 2021-12-18.
- ^ a b c d e "Genomatix Annotation (ElDorado)". Genomatix. Archived from the original on 2012-01-14.
- ^ a b "Tissue expression of C5orf22 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2021-12-18.
- ^ "DROSHA drosha ribonuclease III [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-18.
- ^ "DROSHA - Ribonuclease 3 - Homo sapiens (Human) - DROSHA gene & protein". www.uniprot.org. Retrieved 2021-12-18.
- ^ a b c d "ELM - Search the ELM resource". elm.eu.org. Retrieved 2021-12-18.
- ^ a b "C5orf22 - UPF0489 protein C5orf22 - Homo sapiens (Human) - C5orf22 gene & protein". www.uniprot.org. Retrieved 2021-12-18.
- ^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2021-12-18.
- ^ "PSORT II Prediction". psort.hgc.jp. Retrieved 2021-12-18.
- ^ "DeepLoc1.0 C5orf22". DTU Health Services. Archived from the original on 2020-08-15.
- ^ "NLS Mapper". nls-mapper.iab.keio.ac.jp. Archived from the original on 2021-11-22. Retrieved 2021-12-18.
- ^ PMID 31846293.
- ^ "IntAct Portal". www.ebi.ac.uk. Retrieved 2021-12-18.
- ^ a b "C5orf22 Result Summary | BioGRID". thebiogrid.org. Retrieved 2021-12-18.
- ^ "Results - mentha: the interactome browser". www.mentha.uniroma2.it. Retrieved 2021-12-18.
- ^ "Motif Scan". myhits.sib.swiss. Retrieved 2021-12-18.
- ^ a b c "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2021-12-18.
- ^ a b "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2021-12-18.
- ^ "miRDB - MicroRNA Target Prediction Database". www.mirdb.org. Retrieved 2021-12-18.
- S2CID 226312590.
- ^ "GDS4843 / 1552660_a_at". www.ncbi.nlm.nih.gov. Retrieved 2021-12-18.