CDH8
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| Location (UCSC) | Chr 16: 61.65 – 62.04 Mb | Chr 8: 99.75 – 100.14 Mb | |||||||
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Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.[5][6][7]
Function
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.[7]
Clinical significance
Disruptions of CDH8 in humans have been implicated in
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150394 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036510 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9615235.
- PMID 2059658.
- ^ a b "Entrez Gene: CDH8 cadherin 8, type 2".
- PMID 20972252.
- PMID 27018473.
Further reading
- Tanihara H, Sano K, Heimark RL, St John T, Suzuki S (Apr 1994). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhesion and Communication. 2 (1): 15–26. PMID 7982033.
- Kido M, Obata S, Tanihara H, Rochelle JM, Seldin MF, Taketani S, Suzuki ST (Mar 1998). "Molecular properties and chromosomal location of cadherin-8". Genomics. 48 (2): 186–94. PMID 9521872.
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (Jul 2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". The Biochemical Journal. 349 (Pt 1): 159–67. PMID 10861224.
- Blaschke S, Mueller CA, Markovic-Lipkovski J, Puch S, Miosge N, Becker V, Mueller GA, Klein G (Oct 2002). "Expression of cadherin-8 in renal cell carcinoma and fetal kidney". International Journal of Cancer. 101 (4): 327–34. S2CID 7052911.
External links
- CDH8 human gene location in the UCSC Genome Browser.
- CDH8 human gene details in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P97291 (Mouse Cadherin-8) at the PDBe-KB.
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