Cyrus Chothia

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Cyrus Chothia
FRS
Chothia in 2015
Born
Cyrus Homi Chothia

(1942-02-19)19 February 1942[18]
Died26 November 2019(2019-11-26) (aged 77)[19]
EducationAlleyn's School[20]
Alma mater
Awards
Scientific career
Institutions
ProQuest 301370414 The crystal structures of some molecules active at cholinergic nerve receptors] (1973)
Doctoral advisorPeter J. Pauling[4]
Other academic advisorsMichael Levitt[5]
Frederic M. Richards[5]
Doctoral students
Other notable students
postdoc
)
Websitewww2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/cyrus-chothia

Cyrus Homi Chothia (19 February 1942 – 26 November 2019)

Laboratory of Molecular Biology (LMB) at the University of Cambridge[22][23] and emeritus fellow of Wolfson College, Cambridge.[21][24][25][26][27][28][29]

Education

Chothia was educated at Alleyn's School,[20] then went to study at Durham University graduating with a Bachelor of Science degree in 1965.[18] Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a PhD from University College London[30] under the supervision of Peter Pauling [Wikidata],[31] the son of Linus Pauling.

Research and career

After his PhD Chothia worked in the

Institut Pasteur in Paris.[34]

In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk[3][35] he showed that proteins adapt to mutations by changes in structure.

In 1992 he proposed that most proteins are built of domains that come from a small number of families.

Hidden Markov models
to identify protein sequences that are related to those of known structures.

During his career, Chothia supervised 19 successful PhD students to completion

Mark Bender Gerstein,[11] Julian Gough,[13] Sarah Teichmann,[15] Bissan Al-Lazikani,[41][42][43] Goga Apic,[44] Samantha Barré[citation needed][45] Matthew Bashton,[46][47][48][49] Dan Bolser,[50] Michael Bremang,[51] Bernard de Bono,[52][53] Emma Ganley (née Hill),[54][55][56] Martin Madera,[57][58] Siarhei Maslau,[59] Susan Miller,[60][61][62] Jong Park (aka Jong Bhak),[63][64][65] Rajkumar Sasidharan,[66][67] and Christine Vogel.[68][69]

Awards and honours

Chothia was elected a

Fellow of the Royal Society (FRS) in 2000.[18] His certificate of election and candidature reads:

Dr Chothia has shown how the amino sequences of proteins determine their structure, function and evolution. From an analysis of their structural regularities, he has developed a classification of protein structures that is now in general use. His picture of protein evolution suggests how proteins diverge and gain new functions. He has helped us to understand how their apparently limited set of slightly different structures allow immunoglobin to recognise an almost limitless variety of different antigens.[70]

In 2015, Chothia was elected a Fellow of the

ISCB Accomplishment by a Senior Scientist Award in honour of his work in using computational methods to understand protein structure.[1][72]

Alongside David Haussler and Michael Waterman, Chothia was awarded the 2015 Dan David Prize for his contributions to the field of bioinformatics.[2]

References

Scholia has a profile for Cyrus Chothia (Q5201079).
  1. ^ a b "ISCB Cyrus Chothia, Curtis Huttenhower, and Larry Hunter Named 2015 ISCB Award Winners". Archived from the original on 11 February 2015.
  2. ^ a b "Wikipedia co-founder Jimmy Wales among 2015 Dan David Prize winners". Retrieved 13 February 2015.
  3. ^
    PMID 7373651
    .
  4. ^ a b Cyrus Chothia at the Mathematics Genealogy Project
  5. ^ a b c "Cyrus H. Chothia, Chemistry Tree". Archived from the original on 27 February 2015.
  6. ^ a b Bateman, Alexander George (1997). Evolution of the structure and function of the immunoglobulin superfamily (PhD thesis). University of Cambridge.
  7. ^ "Dr Alex Bateman – Wellcome Trust Sanger Institute". Archived from the original on 7 February 2012.
  8. PMID 8880921
    .
  9. S2CID 20501031
    .
  10. ^
    EThOS uk.bl.ethos.596888
    .
  11. ^ a b Gerstein, Mark Bender (1992). Protein recognition : surfaces and conformational change (PhD thesis). University of Cambridge.
  12. PMID 2067013
    .
  13. ^
    EThOS uk.bl.ethos.599547. Archived from the original
    (PDF) on 11 March 2015.
  14. ^ a b "Dr. Julian Gough's home page at the University of Bristol". Archived from the original on 25 March 2012.
  15. ^ a b Teichmann, Sarah Amalia (1999). Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge.
  16. PMID 9367767
    .
  17. PMID 9843945. Open access icon
  18. ^
    doi:10.1093/ww/9780199540884.013.10866. (Subscription or UK public library membership
    required.)
  19. ^ a b "Cyrus Chothia (1942–2019)". 27 November 2019. Retrieved 27 November 2019.
  20. ^ a b "Dan David Prize Awarded to Dr Cyrus Chothia". Alleyn's School. Archived from the original on 23 March 2015.
  21. ^ a b "Wolfson College: Emeritus Fellow Dr Cyrus Chothia MA MSc FRS". Archived from the original on 5 February 2012.
  22. ^ "Cyrus Chothia: The protein origins of biological complexity, LMB Emeritus". Archived from the original on 15 February 2012.
  23. ^ "Structural genomics and protein structure". Mrc-lmb.cam.ac.uk. Archived from the original on 14 February 2015. Retrieved 24 June 2014.
  24. ^ Cyrus Chothia at DBLP Bibliography Server Edit this at Wikidata
  25. ^ "cyrus chothia". Google Scholar. Retrieved 24 June 2014.
  26. S2CID 4241051
    .
  27. PMID 25348407
    .
  28. S2CID 27681885
    .
  29. ^ Cyrus Chothia's publications indexed by the Scopus bibliographic database. (subscription required)
  30. ProQuest 301370414
    .
  31. PMID 4311249
    .
  32. PMID 270659
    .
  33. S2CID 4154884
    .
  34. PMID 4472048
    .
  35. PMID 7248454
    .
  36. S2CID 4355476
    .
  37. PMID 9016544
    .
  38. ^ "UK government grants awarded to Cyrus Chothia". Research Councils UK. Archived from the original on 15 October 2014.
  39. PMID 11752312
    .
  40. ^ Alex Bateman (2015). "Cyrus Chothia's academic family tree". twitter. Archived from the original on 15 July 2015.
  41. ^ Al-Lazikani, Bissan (1999). Canonical structures of immunoglobulins and T cell receptors (PhD thesis). University of Cambridge.
  42. ^ "Dr Bissan Al-Lazikani Team leader". The Institute of Cancer Research. Archived from the original on 5 March 2015.
  43. PMID 10656805
    .
  44. EThOS uk.bl.ethos.619919
    .
  45. S2CID 39728494
    .
  46. ^ Bashton, Matthew (2004). Functional analysis of domain combinations (PhD thesis). University of Cambridge.
  47. ^ "Dr Matthew Bashton: Research Associate: INSTINCT project". Archived from the original on 5 March 2015.
  48. PMID 11812158
    .
  49. PMID 17223535
    .
  50. ^ Bolser, Daniel Murray (2007). The surfaces involved in the formation of protein complexes (PhD thesis). University of Cambridge.
  51. ^ Bremang, Michael Anthony (2012). The mouse protein repertoire : studies on alternative splicing, function and quality (PhD thesis). University of Cambridge.
  52. ^ de Bono, Bernard (2004). Immunoglobulin superfamily proteins in human and mouse (PhD thesis). University of Cambridge.
  53. PMID 14576296
    .
  54. ^ Hill, Emma Elizabeth (2002). Evolution of protein families: genome sequences and three dimensional structures (PhD thesis). University of Cambridge.
  55. ^ "Emma Hill's Homepage". University of California, Berkeley. Archived from the original on 13 July 2006.
  56. ^ "Emma Ganley (née Hill) PLOS staff". PLOS. Archived from the original on 24 April 2015.
  57. ^ Madera, Martin (2005). Hidden Markov models for detection of remote homology (PhD thesis). University of Cambridge.
  58. PMID 14681402
    .
  59. ^ Maslau, Siarhei (2007). Formation of the small molecule metabolism of Escherichia coli (PhD thesis). University of Cambridge.
  60. OCLC 59769936
    .
  61. PMID 3681970
    .
  62. S2CID 4349684
    .
  63. ^ Park, Jong Hwa (1997). Genome sequence analysis and methods (PhD thesis). University of Cambridge.
  64. ^ Cyrus Chothia publications indexed by Google Scholar
  65. ^ "Jong Bhak's home page: An entrepreneur and a scientist". jongbhak.com. Archived from the original on 20 December 2014.
  66. ^ Sasidharan, Rajkumar (2004). Protein evolution : the selection of acceptable mutations (PhD thesis). University of Cambridge.
  67. PMID 17540730
    .
  68. ^ Vogel, Christine (2004). A domain perspective on the evolution of the protein repertoire (PhD thesis). University of Cambridge.
  69. PMID 16733546. Open access icon
  70. ^ "EC/2000/04: Chothia, Cyrus". London: Royal Society. Archived from the original on 29 March 2022. Retrieved 18 November 2013.
  71. PMID 26002905
    .
  72. ^ "Meet the ISCB Fellows Class of 2015". Archived from the original on 20 February 2015. Retrieved 15 February 2015.

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