Hanah Margalit

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Hanah Margalit
Systems Biology[3]
InstitutionsHebrew University of Jerusalem
National Institutes of Health
Doctoral advisorNorman Grover
Other academic advisorsCharles DeLisi
Websitemargalit.huji.ac.il

Hanah Margalit is a

gene regulation in bacteria and eukaryotes.[3]

Education

Margalit earned her B.Sc degree (in Mathematics and Biology, 1974) and MSc degree (in Genetics, with distinction, 1977) from the Hebrew University of Jerusalem.

PhD in computational molecular biology, under the supervision of Norman Grover, the Hebrew University of Jerusalem.[citation needed
]

Career and research

Margalit completed

mathematical biology under the supervision of Charles DeLisi, where she developed the first computational algorithm to predict antigenic peptides recognized by immune cells.[6]
In 1989, she returned to Israel and established her independent research group at the Faculty of Medicine, the Hebrew University of Jerusalem.

Her early research included development of computational algorithms for predicting binding of antigenic peptides to

protein-DNA interactions[12] (in collaboration with Uri Alon), as well as computational models for predicting small regulatory RNA molecules in bacteria,[13]
which were verified experimentally in collaboration with Shoshy Altuvia and Gerhart Wagner.

More recently, Margalit's lab studied the dynamics of regulation by small RNAs [14] (in collaboration with Ofer Biham), and computationally predicted that there are viral microRNA molecules that repress the human immune system, a mechanism that was experimentally validated in collaboration with Ofer Mandelboim.[15] Since 2012, Margalit has combined experimental and computational research for studying small RNA-target interactions in bacteria.[16]

Margalit was one of pioneering researchers of Bioinformatics and Computational Biology in Israel and worldwide. At the Hebrew University she co-founded the "Computer Science and Life Sciences" program in Bioinformatics and Computational Biology (in 1999) and the graduate "Genomics and Bioinformatics" program (in 2000). In 2002 she was elected as the first president of the Israeli Society of Bioinformatics and Computational Biology (2002-2004). Margalit has mentored over 50 graduate students, many of them holding faculty positions in bioinformatics in Israel and abroad.[17]

Awards and honors

In 2008 she was awarded the

fellow of the International Society for Computational Biology (ISCB) for outstanding contributions to the fields of computational biology and bioinformatics.[1]
In 2020, Prof. Margalit was awarded the Rothschild Prize in Computational Biology.[19]

Personal life

Margalit is married to Avi and a mother of three children.[citation needed]

References

  1. ^ a b Anon (2018). "ISCB Fellows". iscb.org. International Society for Computational Biology. Archived from the original on 2015-04-15. Retrieved 2018-03-13.
  2. ^ "The Rothschild Prize". The Rothschild Prize. Retrieved 7 March 2020.
  3. ^ a b Hanah Margalit publications indexed by Google Scholar Edit this at Wikidata
  4. ^ a b "Keynotes Details". www.iscb.org. Retrieved 2018-11-28.
  5. ^ "Hanah Margalit's Lab". margalit.huji.ac.il.
  6. PMID 2435793
    .
  7. PMID 7540211
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  8. PMID 7563096
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  9. PMID 9580679
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  10. PMID 16103898
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  11. PMID 11518523
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  12. PMID 15079056
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  13. PMID 11448770
    .
  14. PMID 17893699
    .
  15. PMID 17641203
    .
  16. PMID 27588604
    .
  17. ^ "Hanah Margalit's Lab". margalit.huji.ac.il. Retrieved 2018-11-28.
  18. ^ "קרן לנדאו - פרס למדעים ומחקר" (in Hebrew). 2012-06-17. Archived from the original on 2012-06-17. Retrieved 2018-11-28.
  19. ^ "The Rothschild Prize". The Rothschild Prize. Retrieved 7 March 2020.
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