Cytochrome-c3 hydrogenase
| cytochrome-c3 hydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a cytochrome-c3 hydrogenase (EC 1.12.2.1) is an enzyme that catalyzes the chemical reaction
- 2 H2 + ferricytochrome c3 4 H+ + ferrocytochrome c3
Thus, the two
substrates of this enzyme are H2 and ferricytochrome c3, whereas its two products are H+ and ferrocytochrome c3
.
This enzyme belongs to the family of
Iron-sulfur
.
Structural studies
As of late 2007, 19
structures have been solved for this class of enzymes, with PDB accession codes 1FRV, 1H2R, 1UBH, 1UBJ, 1UBK, 1UBL, 1UBM, 1UBO, 1UBR, 1UBT, 1UBU, 1WUH, 1WUI, 1WUJ, 1WUK, 1WUL, 1YQ9, 1YQW, and 1YRQ
.
References
- DerVartanian DV; Le Gall J (1974). "A monomolecular electron transfer chain: structure and function of cytochrome c3". Biochim. Biophys. Acta. 346 (1): 79–99. PMID 4364940.
- Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H (1987). "Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F". J. Biol. Chem. 262 (6): 2823–5. PMID 3546297.
- Rilkis E; Rittenberg D (1961). "Some observations on the enzyme, hydrogenase". J. Biol. Chem. 236: 2526–2529. PMID 13741672.
- Sadana JC; Morey AV (1961). "Purification and properties of the hydrogenase of Desulfovibrio desulfuricans". Biochim. Biophys. Acta. 50: 153–163. PMID 13745271.
- Fontecilla-Camps JC; Charon, MH; Piras, C; Hatchikian, EC; Frey, M; Fontecilla-Camps, JC (1995). "Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas". Nature. 373 (6515): 580–7. S2CID 4335445.
- Fontecilla-Camps JC; Vernede, X; Hatchikian, EC; Volbeda, A; Frey, M; Fontecilla-Camps, JC (1999). "The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center". Structure. 7 (5): 557–66. PMID 10378275.
