Demecarium bromide

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Not to be confused with Decamethonium.
Demecarium bromide
Clinical data
Trade namesHumorsol
Routes of
administration		Topical (ophthalmic solution)
ATC code
Identifiers
  • Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylammoniophenoxy)carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide
JSmol)
  • [Br-].[Br-].O=C(Oc1cccc(c1)[N+](C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)[N+](C)(C)C)C)C
  • InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 checkY
  • Key:YHKBUDZECQDYBR-UHFFFAOYSA-L checkY
 ☒NcheckY (what is this?)  (verify)

Demecarium bromide, trade name Humorsol, is a

parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1]

Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.[3]

Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can be compounded.[5]

Use in dogs

When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[3]

See also

References

  1. ISBN 978-0-323-16916-5
    .
  2. ISBN 9789350253656
    .
  3. ^
    ISBN 978-1-4377-2367-0
    .
  4. ISBN 978-0-323-08790-2
    .
  5. PMID 26319445
    .
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