Endocardial cushions
Endocardial cushions | |
---|---|
Details | |
Carnegie stage | 14 |
Days | 27 |
Precursor | Lateral plate mesoderm[1] |
Gives rise to | Septum intermedium |
Identifiers | |
Latin | tubera endocardiaca atrioventricularia |
MeSH | D054089 |
TE | cushions_by_E5.11.1.6.0.0.4 E5.11.1.6.0.0.4 |
Anatomical terminology |
Endocardial cushions, or atrioventricular cushions, refer to a subset of cells in the development of the heart that play a vital role in the proper formation of the heart septa.
They develop on the atrioventricular canal[2] and conotruncal region of the bulbus cordis.[3]
During heart development, the heart starts out as a tube. As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial cushions are a subset of cells found in the developing heart tube that will give rise to the heart's primitive valves and septa, critical to the proper formation of a four-chambered heart.[4]
Development
The
Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the
Clinical significance
A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect.
See also
References
This article incorporates text in the public domain from page 512 of the 20th edition of Gray's Anatomy (1918)
- PMID 11376439.
- ^ "endocardial cushions" at Dorland's Medical Dictionary
- OCLC 51258190.
- ISBN 978-0-12-801238-3, retrieved 2020-12-05