HBE1
| HBE1 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 11: 5.27 – 5.51 Mb | Chr 7: 103.49 – 103.49 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.[5]
Function
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two
beta - 3'.[6]
See also
- Hemoglobin
- Human β-globin locus
- Hemoglobin alpha chains (two genes, same sequence):
- HBA1
- HBA2
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213931 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052217 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 2649166.
- ^ "Entrez Gene: HBE1 hemoglobin, epsilon 1".
Further reading
- Clegg JB (1982). "Embryonic hemoglobin: sequence of the epsilon and zeta chains". Tex. Rep. Biol. Med. 40: 23–8. PMID 6172865.
- Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. PMID 7555018.
- Chang JC, Kan YW (1979). "beta 0 thalassemia, a nonsense mutation in man". Proc. Natl. Acad. Sci. U.S.A. 76 (6): 2886–9. PMID 88735.
- Proudfoot NJ, Baralle FE (1980). "Molecular cloning of human epsilon-globin gene". Proc. Natl. Acad. Sci. U.S.A. 76 (11): 5435–9. PMID 160554.
- Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211–4. S2CID 4211839.
- Marotta CA, Forget BG, Cohne-Solal M, et al. (1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019–31. PMID 873928.
- Gelinas R, Endlich B, Pfeiffer C, et al. (1985). "G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin". Nature. 313 (6000): 323–5. S2CID 4353948.
- Collins FS, Metherall JE, Yamakawa M, et al. (1985). "A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin". Nature. 313 (6000): 325–6. S2CID 4315881.
- Lang KM, Spritz RA (1985). "Cloning specific complete polyadenylylated 3'-terminal cDNA segments". Gene. 33 (2): 191–6. PMID 2581851.
- Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells". J. Clin. Invest. 83 (3): 1032–8. PMID 2921315.
- Chabot B, Black DL, LeMaster DM, Steitz JA (1986). "The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein". Science. 230 (4732): 1344–9. PMID 2933810.
- Engelke DR, Hoener PA, Collins FS (1988). "Direct sequencing of enzymatically amplified human genomic DNA". Proc. Natl. Acad. Sci. U.S.A. 85 (2): 544–8. PMID 3267215.
- Fei YJ, Stoming TA, Efremov GD, et al. (1988). "Beta-thalassemia due to a T----A mutation within the ATA box". Biochem. Biophys. Res. Commun. 153 (2): 741–7. PMID 3382401.
- Prchal JT, Cashman DP, Kan YW (1986). "Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine". Proc. Natl. Acad. Sci. U.S.A. 83 (1): 24–7. PMID 3455755.
- van Santen VL, Spritz RA (1985). "mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2885–9. PMID 3857622.
- Ruskin B, Greene JM, Green MR (1985). "Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants". Cell. 41 (3): 833–44. S2CID 41979452.
- Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6384–8. PMID 3879975.
- Orkin SH, Antonarakis SE, Kazazian HH (1984). "Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC". J. Biol. Chem. 259 (14): 8679–81. PMID 6086605.
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