Neuroglobin
| Neuroglobin | |||||||
|---|---|---|---|---|---|---|---|
Chr. 14 q24 | |||||||
| |||||||
Neuroglobin is a member of the vertebrate
astrocytes in certain pathologies of the rodent brain[1][2] and in the physiological seal brain.[3] This is thought to be due to convergent evolution.[4] It is of ancient evolutionary origin, and is homologous to nerve globins of invertebrates. Recent research confirmed the presence of human neuroglobin protein in cerebrospinal fluid (CSF).[5]
Neuroglobin was first identified by Thorsten Burmester et al. in 2000.[6]
The 3D structure of human neuroglobin was determined in 2003.murine neuroglobin was determined at a higher resolution.[8]
A practical treatment for carbon monoxide poisoning based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q) appears to be possible.[9]
See also
References
- S2CID 8563830.
- S2CID 12425782.
- S2CID 207246404.
- ^ science.gov, Neuroglobins, Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity by Lechauve, Christophe; Jager, Muriel; Laguerre, Laurent; Kiger, Laurent; Correc, Gaelle; Leroux, Cedric; Vinogradov, Serge; Czjzek, Mirjam; Marden, Michael C.; Bail
- PMID 15730566.
- S2CID 4337897.
- PMID 12962627.
- S2CID 29990150.
- PMID 29566507.
External links
- neuroglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)