Helmy Eltoukhy

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Helmy Eltoukhy
Alma materStanford University
BS, Electrical engineering
MS, Electrical engineering
PhD, Electrical engineering
Stanford Genome Technology Center (Postdoc)
Known forCo-Founder & CEO, Guardant Health
Co-Founder & CEO, Avantome
SpouseCarson Eltoukhy (? - 2020)
Scientific career
FieldsGenomics
Electrical engineering
Thesis An integrated system for de novo DNA sequencing
Doctoral advisorAbbas El Gamal[1][2]

Helmy Eltoukhy is an American

semiconductor DNA sequencing, and personalized medicine. His startups were acquired by Illumina in 2008. Avantome was founded to develop and commercialize semiconductor-based DNA sequencing, during the race for the $1,000 genome.[3] Guardant Health was founded to pioneer non-invasive liquid biopsy approaches for cancer diagnosis, monitoring, personalized medicine treatment, and research.[4][5]

Education

Eltoukhy attended

image sensors coupled to light-emitting DNA sequencing reactions could form the basis for building a less expensive, portable DNA sequencer.[6]

Career

Genome Technology Center

After graduation, Eltoukhy completed a

semiconductor-based approaches for DNA sequencing. That research was funded, in part, by one of the first National Human Genome Research Institute grants awarded for massive parallel sequencing (also known as Next Generation Sequencing or NGS).[12][13]

Avantome and Illumina

In 2007, Eltoukhy and Mostafa Ronaghi co-founded the biotechnology startup company Avantome, to accelerate the commercialization of semiconductor sequencing technologies and affordable high-throughput DNA sequencing.[3][8] Eltoukhy was president and CEO of the new company until 2008, when Avantome was acquired by Illumina.[3][14] As part of the acquisition terms, Ronaghi and Eltoukhy joined Illumina, where Eltoukhy continued pioneering genomic research as director of Advanced Sequencing Development until 2012.[8] At Illumina, Avantome’s CMOS/semiconductor sequencing platform became the basis for Project Firefly, a program to develop an "integrated sequencing solution simple and affordable enough to install in hospitals for routine testing".[3][15] In 2018, Illumina launched iSEQ, a new product developed using Avantome’s CMOS sensor approach combined with nanowell technology; iSEQ delivered on the original Avantome goals of low cost instrumentation and reduced per-sample processing cost in a long read format.[14][16]

Guardant Health

In 2012, Eltoukhy and

ctDNA) fragments released into the bloodstream of people who have cancer, enabling cancer detection and monitoring using minimally-invasive blood tests (liquid biopsies) which are lower cost and lower risk compared to traditional tissue biopsies.[18][19][20]

Under Eltoukhy’s direction as CEO, Guardant Health raised over one billion dollars (US) in financing,

epigenetic signatures of ctDNA in early stage and recurring cancers.[29][31][34]

In 2017, a

went public (IPO) on October 4, 2018.[37] In January 2019, Guardant Health entered a partnership with pharmaceutical company AstraZeneca to develop companion diagnostics.[38][39] In October 2019, the company initiated ECLIPSE, a 10,000 patient colorectal cancer study, in an effort to evaluate the effectiveness of using blood tests to screen for colorectal cancer in the general population.[40][41]

Eltoukhy was named to Time Magazine’s inaugural 50 Most Influential People in Healthcare (2018)[42][43] and Fortune’s 40 under 40 (2017).[44][45]

Representative publications

Journal articles

Patents

  • Engineered luciferases, (2009).[49]
  • Biological analysis arrangement and approach therefor, (2012).[50]
  • Multibase delivery for long reads in sequencing by synthesis protocols, (2012).[51]
  • Methods and systems for detecting genetic variants, (2015).[52]
  • Methods to detect rare mutations and copy number variation, (2016).[53]
  • Methods for multi-resolution analysis of cell-free nucleic acids, (2017).[54]

Recognition

Eltoukhy was named to Time Magazine’s inaugural 50 Most Influential People in Healthcare in 2018, Fortune’s 40 under 40 in 2017,[44][45] and the San Francisco Business Times 40 under 40 in 2019.[55] He has served as an invited speaker or panelist at the World Economic Forum,[56] Fortune Brainstorm Health 2017,[57] The Business of Personalized Medicine Summit 2018,[58][59] HLTH (healthcare innovation) 2018,[60] and the World Medical Innovation Forum 2016.[61]

References

  1. ^ a b "Stanford Engineering, Abbas El Gamal - Previous Students". Stanford University. 2019. Retrieved 5 Nov 2019.
  2. ^ a b c Shinal, John (20 Feb 2015). "More-accurate cancer tests based on computer math". USA Today. Retrieved 5 Nov 2019.
  3. ^ a b c d Carroll, John (23 Jul 2008). "Illumina snares sequencing tech in $60M buyout". fiercebiotech.com. Questex, LLC. Retrieved 19 Oct 2019.
  4. ^ a b Hay, Timothy (17 Jul 2015). "Liquid Biopsy the Key to 'Active Surveillance' of Cancer, Guardant Health Says". The Wall Street Journal. USA. Retrieved 18 Oct 2019.
  5. ISBN 978-1-351-98433-1
    . Retrieved 19 October 2019.
  6. ^ a b c Hindery, Robin (2015). "Keeping Pace with Cancer: Helmy Eltoukhy's startup, Guardant Health, is making waves in the healthcare world by using cutting-edge DNA sequencing technology to track cancer in real time". Gentry Health. California, USA: The Golden State Company. pp. 108–109. Retrieved 19 Nov 2019.
  7. ^ "BellarmineBells". Instagram. Bellarmine College Preparatory. 23 Mar 2016. Retrieved 19 Nov 2019.
  8. ^ a b c d e "Illumina to Buy Avantome for Up to $60M; Long, Cheap Reads Will Target Sanger". genomeweb.com. 29 Jul 2008.
  9. OCLC 71209106
    .
  10. ISBN 978-0-8194-4766-1
    . Retrieved 22 October 2019.
  11. ^ "Human Genome Project Completion: Frequently Asked Questions". genome.gov. National Human Genome Research Institute. Retrieved 22 Oct 2019.
  12. ^ "NHGRI Seeks Next Generation of Sequencing Technologies". genome.gov. 14 Oct 2004. Retrieved 22 Oct 2019. Mostafa Ronaghi, Stanford Genome Technology Center, $1.8 million (3 years) "Pyrosequencing Array for DNA Sequencing"
  13. ^ Ron Kerr, Helmy Eltoukhy, Bambi Francisco (23 Feb 2016). $1,000 is the "right price" for human genome (video). Vator. Retrieved 22 Oct 2019.
  14. ^ a b "Illumina Unveils Mini Targeted Sequencer, Semiconductor Sequencing Project at JP Morgan Conference". GenomeWeb. USA. 11 Jan 2016. Retrieved 16 Oct 2019.
  15. ^ "At AGBT, Illumina Provides Additional Details on Project Firefly". genomeweb.com. 12 Feb 2016.
  16. ^ "Illumina Launches Semiconductor Sequencer, Partners With Thermo Fisher, Releases Prelim Earnings". genomeweb.com. 9 Jan 2018.
  17. ^ a b Medeiros, Joao (7 Feb 2019). "How SoftBank ate the world: Led by the charismatic Masayoshi Son, Japanese conglomerate SoftBank's Vision Fund is taking over tech, one company at a time. This is the story of what happens if the disruptors are disrupted". Wired. Retrieved 25 Oct 2019.
  18. ^ a b Leuty, Ron (11 May 2017). "Blood money: Peninsula liquid biopsy company gets $360M injection". San Francisco Business Times. Retrieved 3 Nov 2019.
  19. ^ a b "Blood-based liquid biopsies are the new frontier in cancer diagnosis". fiercebiotech.com. Questex, LLC. 20 Jul 2015. Retrieved 20 Oct 2019.
  20. ^ a b c Cha, Ariana Eunjung (28 Apr 2016). "There's a new sheriff in town in Silicon Valley — the FDA". The Washington Post. San Francisco, CA, USA. Retrieved 20 Oct 2019.
  21. ^ Terry, Mark (10 Sep 2018). "2 Bay Area Biotechs Launch IPOs Worth a Combined $200 Million". biospace.com. BioSpace. Retrieved 12 Nov 2019.
  22. ^ Fox, Michelle (4 Oct 2018). "Guardant Health soars almost 70% in first day of trading". CNBC. USA. Retrieved 12 Nov 2019.
  23. ^ a b Tansey, Burnadette (19 Sep 2014). "Forum Highlights Innovators Working in Global Public Interest". xconomy.com. Xconomy, Inc. Retrieved 24 Oct 2019.
  24. ^ Leuty, Ron (22 Jan 2015). "9 potential life science IPOs to watch". San Francisco Business Times. USA. Retrieved 25 Oct 2019.
  25. ^ Al Idius, Amirah (11 Dec 2017). "FierceMedTech's Fierce 15, 2017". Fiercebiotech.com. Questex, LLC.
  26. ^ a b c Sawers, Paul (11 May 2017). "Cancer screening firm Guardant Health raises US$360 million to sequence tumor DNA of 1 million patients". VentureBeat. USA. Retrieved 22 Oct 2019.
  27. ^ Regalado, Antonio (24 Jun 2015). "The Great Cancer Test Experiment". MIT Technology Review. MIT. Retrieved 12 Oct 2019.
  28. ^ a b Harper, Matthew (12 Nov 2018). "A $3 Billion Startup's Shares Gain On Hopes For A Cancer Blood Test". Forbes. Retrieved 11 Nov 2019.
  29. ^ a b O'Connor, Leo (9 Jan 2019). "JP Morgan Healthcare, Day 2: Thermo Fisher, Exact Sciences, Guardant, Hologic, Caris, and More". Retrieved 6 Nov 2019.
  30. ISBN 978-1-4903-3040-2
    . Retrieved 8 November 2019.
  31. ^ a b c Philippidis, Alex (27 Mar 2019). "Five-Year Super Successes in Genomics and Precision Medicine". ClinicalOmics. Retrieved 8 Nov 2019.
  32. ^ Teichert, Erica (20 Aug 2016). "Innovations: Startup's liquid biopsies match cancer patients with trials". Modern Healthcare. Crain Communications. Retrieved 22 Oct 2019.
  33. ^ "FDA Grants EAP Designation to Guardant's NGS-Based Liquid Biopsy". fdanews.com. FDA News. 22 Feb 2018. Retrieved 10 Nov 2019.
  34. ^ a b Philippidis, Alex (14 Jan 2019). "Guardant Health Launches Blood-Based Early Cancer Assay for Research Use". Genetic Engineering and Biotechnology News. Mary Ann Liebert. Retrieved 6 Nov 2019.
  35. ^ Baker, Liana; Roumeliotis, Greg (19 May 2017). "Dealmakers aplenty, SoftBank's Son looks for wonks". Reuters. Retrieved 25 Oct 2019.
  36. ^ Terry, Mark (28 Feb 2019). "Guardant Health's Liquid Biopsy Wins in Head-to-Head Trial in Lung Cancer". biospace.com. Retrieved 3 Oct 2019.
  37. ^ "Opening Bell, October 4, 2018: Ringing today's opening bells are Mateusz Morawiecki, Republic of Poland prime minister, at the NYSE, and Guardant Health with CEO Helmy Eltoukhy and President AmirAli Talasaz at the Nasdaq". CNBC. 4 Oct 2018. Retrieved 18 Oct 2019.
  38. ^ Hale, Connor. "Guardant's blood test tracks microsatellite instability status on par with tissue biopsy in new study". FierceBiotech. Quantex, LLC. Retrieved 25 Oct 2019.
  39. ^ "Guardant Health to Develop Blood-Based CDx for AstraZeneca Drugs". genomeweb.com. GenomeWeb. 13 Dec 2018. Retrieved 10 Nov 2019.
  40. ^ Lovelace, Berkeley Jr. (3 Jun 2019). "We're not far from using blood tests to detect early-stage cancer, says CEO of Silicon Valley oncology firm". CNBC. Retrieved 15 Oct 2019.
  41. ^ Columbus, Gina (24 Oct 2019). "Pivotal Study Examines Blood Test as CRC Screening Method". onclive.com. Intellisphere, LLC. Retrieved 12 Nov 2019.
  42. ^ "The Health Care 50: The 50 most influential people in health care (2018)". Time. 18 Oct 2018. Retrieved 25 Oct 2019.
  43. ^ "The Health Care 50: The 50 most influential people in health care (2018) - Helmy Eltoukhy and AmirAli Talasaz". Time. 18 Oct 2018. Retrieved 25 Oct 2019.
  44. ^ a b "Fortune's 40 under 40 (2017)". Fortune. 2017. Retrieved 22 Oct 2019.
  45. ^ a b "Fortune Magazine – Guardant Health CEO And President On This Year's "40 Under 40" List". califesciences.org. California Life Sciences Association. 2017. Retrieved 21 Oct 2019.
  46. S2CID 8813059
    . Retrieved 9 Nov 2019.
  47. S2CID 12890520
    .
  48. PMID 26474073
    .
  49. ^ US application 2009286299, Ronaghi, Mostafa; Eltoukhy, Helmy & Bazargan, Leila, "Engineered luciferases", published 2009-11-19 
  50. The Board of Trustees of the Leland Stanford Junior University
    & inventors.     
  51. ^ US 8236532, Ronaghi, Mostafa & Eltoukhy, Helmy, "Multibase delivery for long reads in sequencing by synthesis protocols", published 2012-08-07, assigned to Illumina, Inc. & inventors. 
  52. ^ EP 3087204, Eltoukhy, Helmy & Talasaz, AmirAli, "Methods and systems for detecting genetic variants", published 2015-07-15, assigned to Guardant Health, Inc. 
  53. ^ EP 2893040, Talasaz, AmirAli & Eltoukhy, Helmy, "Methods to detect rare mutations and copy number variation", published 2016-11-02, assigned to Guardant Health Inc. 
  54. ^ US 9850523, Chudova, Darya; Eltoukhy, Helmy & Mortimer, Stefanie Ann Ward et al., "Methods for multi-resolution analysis of cell-free nucleic acids", published 2017-12-26, assigned to Guardant Health Inc. 
  55. ^ "40 Under 40 Awards". evanta.us. eventa.us. 2019. Retrieved 25 Oct 2019.
  56. ^ "Convening Innovators from the Science and Technology Communities" (PDF). weforum.org. World Economic Forum. 2014. Retrieved 22 Oct 2019.
  57. ^ Mukhurjee, Sy (3 May 2017). "This Simple Cancer Test Comes With a Big Caveat". Fortune. Fortune Media IP Limited. Retrieved 22 Oct 2019.
  58. ^ "The Business of Personalized Medicine". personalizedmedicinesummit.com. BPM Summit. 2018. Retrieved 2 Oct 2019.
  59. ^ "Very Brief Blog: Bay Area "Business of Personalized Medicine Summit" - December 6, 2018". discoveriesinhealthpolicy.com. Discoveries in Health Policy: Ideas for or from an evolving healthcare system. 2018. Retrieved 6 Nov 2019.
  60. ^ "HLTH Announces First 150+ Senior Healthcare Executive Speakers, Including 100+ CEOs and Founders". thekennedyforum.org. The Kennedy Forum. 5 Oct 2017. Retrieved 5 Oct 2019.
  61. ^ "World Medical Innovation Forum 2016" (PDF). neuroscienceinnovationforum.org. World Medical Innovation Forum. 2016. Retrieved 3 Oct 2019.

External links

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