Integral monotopic protein

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Integral monotopic proteins are permanently attached to the cell membrane from one side, and are a type of integral membrane protein (IMP).^[1]

Three-dimensional structures of the following integral monotopic proteins have been determined:

• prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)
• lanosterol synthase and squalene-hopene cyclase
• microsomal prostaglandin E synthase
• carnitine O-palmitoyltransferase 2
• Phosphoglycosyl transferase C

There are also structures of integral monotopic domains of transmembrane proteins:

• monoamine oxidases A and B
• fatty acid amide hydrolase
• mammalian
  cytochrome P450 oxidases
• corticosteroid 11-beta-dehydrogenases

References