Myelin proteolipid protein
| Myelin proteolipid protein (PLP or lipophilin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Myelin_PLP | ||||||||
| Pfam | PF01275 | ||||||||
| InterPro | IPR001614 | ||||||||
| SMART | SM00002 | ||||||||
| PROSITE | PDOC00497 | ||||||||
| |||||||||
Myelin proteolipid protein (PLP or lipophilin)[1] is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation or maintenance of the multilamellar structure of myelin. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the efficiency of axonal impulse conduction.[2]
In humans,
point mutations in PLP are the cause of Pelizaeus–Merzbacher disease (PMD), a neurologic disorder of myelin metabolism. In animals demyelinating diseases
such as mouse 'jimpy' or dog 'shaking pup' are also caused by mutations in PLP.
PLP is a highly conservedpalmitate groups in mammals).[4] PLP is highly related to GPM6A, a neuronal membrane glycoprotein.[5]
Human proteins containing this domain
PLP1
;