CD37
| CD37 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 49.34 – 49.34 Mb | Chr 7: 44.88 – 44.89 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[5][6]
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.[7][8][9][10] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms.[6] CD37 controls both humoral[11][12] and cellular immune responses.[13][14][15] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma,[16] and patients with CD37-negative lymphomas have a worse clinical outcome.[17]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000104894 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030798 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 8899453.
- ^ a b "Entrez Gene: CD37 CD37 molecule".
- S2CID 1756810.
- PMID 19426143.
- S2CID 5906694.
- PMID 28620035.
- PMID 19282981.
- S2CID 21237789.
- PMID 10891477.
- S2CID 5620186.
- S2CID 46297687.
- PMID 26784544.
- PMID 27760757.
Further reading
- Horejsí V, Vlcek C (August 1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Letters. 288 (1–2): 1–4. S2CID 26316623.
- Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. PMID 11739647.
- Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (September 1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 172 (3): 1007. PMID 2388030.
- Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (April 1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 169 (4): 1497–502. PMID 2466944.
- Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (February 1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". Journal of Immunology. 140 (3): 905–14. S2CID 23948434.
- Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics. 39 (4): 249–56. S2CID 20252327.
- Wright MD, Rochelle JM, Tomlinson MG, Seldin MF, Williams AF (February 1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". PMID 8452817.
- Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, et al. (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 (1): 103–11. PMID 10229664.
- Okochi H, Mine T, Nashiro K, Suzuki J, Fujita T, Furue M (July 1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". Journal of Clinical Gastroenterology. 29 (1): 63–7. PMID 10405235.
- Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". International Archives of Allergy and Immunology. 120 (Suppl 1): 38–44. S2CID 39289159.
- van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, et al. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. S2CID 5620186.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. PMID 15342556.
- Meyer-Wentrup F, Figdor CG, Ansems M, Brossart P, Wright MD, Adema GJ, et al. (January 2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". Journal of Immunology. 178 (1): 154–62. PMID 17182550.
- Zhao X, Lapalombella R, Joshi T, Cheney C, Gowda A, Hayden-Ledbetter MS, et al. (October 2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood. 110 (7): 2569–77. PMID 17440052.
External links
- CD37+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD37 genome location and CD37 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.