Isethionic acid

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Isethionic acid
Skeletal formula
ball-and-stick model
Isethionic acid
Names
Preferred IUPAC name
2-Hydroxyethane-1-sulfonic acid
Identifiers
3D model (
JSmol
)
ChEBI
ChemSpider
ECHA InfoCard
 100.003.169 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6) checkY
    Key: SUMDYPCJJOFFON-UHFFFAOYSA-N checkY
  • InChI=1/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6)
    Key: SUMDYPCJJOFFON-UHFFFAOYAO
  • O=S(=O)(O)CCO
Properties
C2H6O4S
Molar mass 126.13 g/mol
Density 1.63 g/cm3
Acidity (pKa) 1.39 (predicted)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Isethionic acid is an

hydroxy group. Its discovery is generally attributed to Heinrich Gustav Magnus, who prepared it by the action of solid sulfur trioxide on ethanol in 1833.[1]
It is a white water-soluble solid used in the manufacture of certain surfactants and in the industrial production of taurine. It is most commonly available in the form of its sodium salt (sodium isethionate).

Synthesis

The original synthesis of the compound, involving the reaction of sulfur trioxide with ethanol, has largely been replaced by more advanced methods. An alternative production method involves the hydrolysis of carbyl sulfate, which is derived from the sulfonation of ethylene.

However the most common route is the reaction of ethylene oxide with aqueous sodium bisulfite, which produces the sodium salt (sodium isethionate):

Reactions

Isethionic acid is used as a starting material in the industrial production of taurine.

Dehydration of isethionic acid gives vinylsulfonic acid.[2]

Derivatives

sodium lauryl sulfate)[4]
making them popular for use in make-up, shampoos and detergent bars including those made by Dove.

Isethionic acid is also used as a

counter ion in certain pharmaceutical formulations, including the antimicrobials hexamidine and pentamidine.[5]

Biological importance

Studies made on dog heart slices suggested that heart tissue may be capable of converting taurine to isethionic acid, further experiments demonstrated that this tissue may synthesize taurine from cystine.[6]

See also

References

  1. ISSN 0003-3804
    .
  2. ISBN 3-527-30673-0
    .
  3. S2CID 41819056
    .
  4. S2CID 418996
    .
  5. ^ Wicho, H, ed. (2009). Austria-Codex Stoffliste (in German) (42 ed.). Vienna: Österreichischer Apothekerverlag.
  6. PMID 14490797
    .
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