KIAA0408
![]() | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (May 2019) |
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Gene
Location and Features
Gene KIAA0408 is located on chromosome Chr 6orf174, which is considered to be a "complex locus" as it merges two NCBI genes and produces multiple proteins that have no sequence overlap.[1] It has 6 exons, 4 are non-overlapping and 2 are "cassette exons".[1] c6orf174 694 amino acids long.[2]
The
Variants and Aliases
KIAA0408 has at least 11 spliced variants.1 Aliases include C6orf174andKIAA0408, FLJ43995, RP3-403A15.2,dJ403A15.3, C6orf174, LOC 9729, jajer, barspoyby, gyperbu.1 It has been described as hypothetical protein LOC9729, OTTHUMP00000017174, and hypothetical protein LOC 387104.1 UniProtKB refers to it as K0408_HUMAN,Q6ZU52.[citation needed]
Expression
KIAA0408 appears to be expressed highest in the brain, fat, and lung tissues. KIAA0408 is also associated with the
Regulation of Expression
According to the SUMO-sumoylation prediction in
Protein
KIAA0408 has 694 amino acids and a
Interacting Proteins
KIAA0408 has 42 total interacting proteins.[citation needed]
Orthologs
The
All birds had very little variation in gene length, % identity, and % similarity. The two turtles that had the gene were also similar in those areas. All mammals aside from the lemur and the monkey had around the same gene lengths, % identity, and % similarity. The lemur and the monkey varied from each other.[citation needed]
Human and mouse KIAA0408 are 53.531% similar and have 149 similar positions. There is a large region that is missing in mouse in the C-terminus, and another smaller chunk missing in the N-terminus. This could be an evolutionary sign of humans' erroneous development of more genes to make them more complex individuals. The areas before and after both deletions are highly conserved, so these are likely very critical regions of the gene.[citation needed]
Clinical Significance
KIAA0408 is highly expressed in the brain, but has also been found in tissue of the breast, testes, eye, kidney, and
References
- ^ a b c d "Homo sapiens complex locus C6orf174andKIAA0408, encoding KIAA0408 and chromosome 6 open reading frame 174".
- ^ a b "KIAA0408 KIAA0408 [Homo sapiens (Human)] - Gene - NCBI".
- ^ "KIAA0408 Gene - GeneCards | K0408 Protein | K0408 Antibody".
- ^ a b c "KIAA0408 Single Gene - Clinical test - NIH Genetic Testing Registry (GTR) - NCBI".
External links
- "UniProt entry on Q6ZU52 (K0408_HUMAN)".
- Zhao, Jingming; Cheng, Wei; He, Xigang; Liu, Yanli; Li, Ji; Sun, Jiaxing; Li, Jinfeng; Wang, Fangfang; Gao, Yufang (May 2018). "Construction of a specific SVM classifier and identification of molecular markers for lung adenocarcinoma based on lncRNA-miRNA-mRNA network". OncoTargets and Therapy. 11: 3129–3140. PMID 29872324.
- Nakamura, Seiji; Kawai, Kozo; Takeshita, Yumie; Honda, Masao; Takamura, Toshinari; Kaneko, Shuichi; Matoba, Ryo; Matsubara, Kenichi (February 2012). "Identification of blood biomarkers of aging by transcript profiling of whole blood". Biochemical and Biophysical Research Communications. 418 (2): 313–318. PMID 22266314.