Leonard R. Stephens

Source: Wikipedia, the free encyclopedia.

Len Stephens
Nationality
British
Alma materUniversity of Birmingham
Scientific career
Fieldsimmunology, signal transduction
InstitutionsBabraham Institute

Leonard (Len) R Stephens

molecular biologist, senior group leader and associate director at the Babraham Institute
.

Len Stephens has contributed much to the understanding of

neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.[2]
Together with his long-time collaborator
PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.[3]
They identified and isolated the
Ras, and proved its role in inflammatory events in vivo.[4]
They – in parallel with Dario Alessi – identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival.[5] Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter.[6]

Life

Len Stephens received a

PhD in Physiology (1984) from the University of Birmingham. After a post-doctoral training in S.K. & F. Research Ltd, he joined the AFRC IAPGR (now Babraham Institute). He became a staff scientist in the Inositide laboratory in 1992 and took the leadership of the laboratory in 1996. In 2008, he became associate director of the Babraham Institute
.

Awards and recognition

Len Stephens has received several awards, including:

  • 2011, elected
    Fellow of the Royal Society of London
  • 2009, elected member of the
    European Molecular Biology Organisation
    (EMBO)

References

  1. ^ royalsociety.org http://royalsociety.org/people/leonard-stephens/. Retrieved 12 January 2014. {{cite web}}: Missing or empty |title= (help)[title missing]
  2. S2CID 12322154
    .
  3. S2CID 4310878
    .
  4. S2CID 53255676
    .
  5. PMID 9445477
    .
  6. PMID 9228007
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Leonard_R._Stephens&oldid=1206948122"