Ligandrol

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Ligandrol
Clinical data
Other namesLGD4033; VK5211; VK-5211; Ligandrol; Anabolicum
Routes of
administration		By mouth[1][2]
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Elimination half-life24–36 hours[3][2][4]
Identifiers
  • 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
JSmol)
  • FC([C@H](O)[C@H]1CCCN1C2=CC(=C(C#N)C=C2)C(F)(F)F)(F)F
  • InChI=1S/C14H12F6N2O/c15-13(16,17)10-6-9(4-3-8(10)7-21)22-5-1-2-11(22)12(23)14(18,19)20/h3-4,6,11-12,23H,1-2,5H2/t11-,12-/m1/s1
  • Key:OPSIVAKKLQRWKC-VXGBXAGGSA-N

LGD-4033, also known by the developmental code name VK5211 and by the black-market name Ligandrol, is a

muscle strength in preliminary clinical trials, but is still being developed and has not been approved for medical use.[5][6][7][8] The drug is taken by mouth.[1][2]

Known possible

prostate gland.[12][3][13]

LGD-4033 was first described in 2010.[12][4] It is less clinically studied than other SARMs like enobosarm, with only a few small clinical trials having been conducted and reported.[14][11][9][2][8] LGD-4033 has not yet completed clinical development or been approved for any use.[5][10][3] As of 2023, it is in phase 2 clinical trials for the treatment of hip fracture and muscle atrophy.[5] LGD-4033 was developed by Ligand Pharmaceuticals, and is now being developed by Viking Therapeutics.[5]

Aside from its development as a potential

safety.[3][9] Many products sold online that are purported to be LGD-4033 either contain none or contain other unrelated substances.[3][16] Social media has played an important role in facilitating the widespread non-medical use of SARMs.[17]

Medical uses

LGD-4033 is not approved for any medical use and is not available as a licensed

pharmaceutical drug as of 2023.[5][10][3]

Side effects

heart attack and stroke.[18]

alanine aminotransferase (ALT), have not been reported with LGD-4033 in the few conducted clinical trials thus far.[6][9] However, multiple case reports of hepatotoxicity with LGD-4033 in the setting of non-medical use have been published.[11][6][9][19]

LGD-4033 and other SARMs are largely uncharacterized in terms of their potential for

safety of high doses of LGD-4033 and other SARMs, which are often used in non-medical contexts, are unknown.[3] Anecdotal reports of masculinization with black-market SARMs in women exist in online forums.[17]

The United States Food and Drug Administration (FDA) claims that "liver toxicity, adverse effects on blood lipid levels, and a potential to increase the risk of heart attack and stroke" are among the potential adverse health effects of SARMs including LGD-4033.[20]

Overdose

LGD-4033 has been assessed in clinical trials at single doses ranging from 0.1 to 22 mg and at repeated doses ranging from 0.1 to 2 mg/day for 3 to 12 weeks.[11] The drug sold via black-market Internet suppliers and used non-medically is often taken at much higher doses than those used in repeated-dose clinical trials (e.g., 5–10 mg/day), with unknown adverse effects and risks.[3][9][11]

Pharmacology

Pharmacodynamics

LGD-4033 is a

prostate gland and sebaceous glands.[12][3][13][24][25]

LGD-4033 has shown robust selectivity for stimulation of the levator ani muscle relative to stimulation of the prostate in rats.[12] At the highest assessed dose in castrated male rats, levator ani weight was increased to around 140% of that of gonadally intact controls, whereas prostate weight was only increased to around 45% of that of intact controls.[13] The tissue selectivity of LGD-4033 was independent of local tissue drug concentration, suggesting that its selectivity was intrinsic.[12][13] The muscle-stimulating effects of LGD-4033 have also been confirmed in humans in preliminary clinical trials.[10][26] The data also allow comparison between different SARMs and other AR agonists.[10][26] In a phase 1 clinical trial in 76 healthy young men, 1 mg/day LGD-4033 increased lean body mass by 1.2 kg after 3 weeks of treatment.[10][26][2] For comparison, enobosarm, another SARM, increased lean body mass by 1.3 kg at a dose of 3 mg/day after 12 weeks in healthy elderly men and postmenopausal women.[2][26][27] It was concluded that the employed dose of LGD-4033 produced similar increases in lean body mass compared to enobosarm despite a substantially shorter treatment period.[2] In a phase 2 clinical trial in 108 women and men with hip fracture, LGD-4033 increased lean body mass by 4.8% at 0.5 mg/day, 7.2% at 1 mg/day, and 9.1% at 2 mg/day after 12 weeks of treatment.[8] For comparison, lean body mass with enobosarm 3 mg/day after the same time period of 12 weeks increased by about 0.30% at 0.1 mg/day, 0.40% at 0.3 mg/day, 1.2% at 1 mg/day, and 3.1% at 3 mg/day, with only the latter change achieving statistical significance.[27] Relative to SARMs, supraphysiological doses of testosterone (300–600 mg/week intramuscular testosterone enanthate) over similar timeframes, like 20 weeks, have been found to result in lean body mass gains of 5 to 8 kg in healthy young men.[28][3][29]

In addition to selectivity for muscle and bone over the prostate gland, LGD-4033 has also been stated by Ligand Pharmaceuticals researchers to have reduced strength in the sebaceous glands.[12][4] Reduced activity in stimulating sebaceous gland formation, to about 30 to 50% of that produced by DHT at doses with similar anabolic potency in rats, has also been reported for certain other SARMs, like the steroidal agents TFM-4AS-1 and MK-0773.[12] In addition, enobosarm and MK-0773 have been reported to limitedly stimulate the sebaceous glands in small short-term clinical studies in women.[30][27][31]

Pharmacokinetics

LGD-4033 showed

elimination half-life of LGD-4033 is 24 to 36 hours.[3][2][4] Pharmacokinetic studies of LGD-4033 for purposes of doping detection have also been conducted.[32][33][34][35]

Chemistry

LGD-4033 is a

tricyclic quinoline, was the predecessor compound of LGD-4033.[10] The chemical structure of LGD-4033 had not been disclosed as late as 2013.[12][26] LGD-4033 has sometimes been confused with other structurally related Ligand Pharmaceuticals SARMs including LGD-2226, LGD-2941, and LGD-3303,[10][5] but is a different compound from these agents.[12][10]

LGD-4033 is a

molecular weight = 338.3 g/mol) and highly lipophilic (predicted log P = 3.6–3.7) compound.[36][37]

History

The predecessor of LGD-4033,

bicyclic quinoline SARM, was subsequently developed by Ligand Pharmaceuticals and TAP Pharmaceuticals in 2001.[39] Other quinoline SARMs, like LGD-2941 and LGD-3303, were also subsequently developed by Ligand Pharmaceuticals prior to the development of LGD-4033.[12][40]

LGD-4033 was developed by Ligand Pharmaceuticals and was first described in the literature in 2010.

acute illness was being prepared by Ligand Pharmaceuticals.[12][1] On 22 May 2014, Viking Therapeutics licensed the developmental rights of LGD-4033 from Ligand Pharmaceuticals and intended to advance the compound into mid-to-late-stage clinical trials.[10] The phase 2 study of LGD-4033 for muscle wasting was finally initiated in November 2016[41] and was completed with results reported in 2017 and 2018.[14][10][8] As of March 2023, LGD-4033 (VK5211) continues to be under development by Viking Therapeutics and continues to be in phase 2 clinical trials for treatment of muscle atrophy and hip fracture.[5]

Society and culture

Regulatory information

In the United States, LGD-4033 is an Investigational New Drug and is not approved for any medical use.[5]

Non-medical use

Though not an approved drug, LGD-4033 (Ligandrol) has been sold on the black market in countries where it is classified as an illegal substance.[42][43] Along with enobosarm (ostarine; GTx-024, S-22), andarine (GTx-007; S-4), and vosilasarm (RAD140; "testolone"), LGD-4033 is one of the most popular and common non-medically-used SARMs.[9][44] Many products sold online that are purported to be LGD-4033 either contain none or contain other unrelated substances, and doses are also frequently not as labeled.[3][16] Social media has played an important role in facilitating the widespread non-medical use of SARMs.[17]

On 23 October 2017, a nutritional supplement company in Missouri called Infantry Labs was warned by the FDA that the distribution of two of its products violated the

prescription drugs" and were instructed to document the steps they would take in order to cease the violation.[20]

Also on 23 October 2017, the FDA sent a warning letter to a New Jersey company called Panther Sports Nutrition. The company's marketing approach for the product was similar to that of the Infantry Labs case, and the product was advertised as a "mass builder" and "physique enhancing agent".[45]

Doping in sport

LGD-4033 is on the

metabolites present in human urine, and suggested an expansion of the WADA regime.[47] LGD-4033 has been found in WADA samples and in racehorses as well.[48]

List of doping cases

Further information:
List of doping in sport cases § Ligandrol

In 2015, the quarterback of the Florida Gators, Will Grier, was suspended for testing positive for LGD-4033, a claim that the University of Florida denies.[49]

In 2017,

NBA for testing positive for LGD-4033.[50]

In 2019, Australian swimmer Shayna Jack tested positive for LGD-4033. She denies knowingly taking the substance.[51]

In August 2019, it came to light that Canadian sprint canoeist

Laurence Vincent Lapointe tested positive for LGD-4033; the athlete denies knowingly taking a forbidden substance that resulted in her suspension from competition. The athlete remarked that the National Team Training Centre purchased nutritional supplements for its athletes and denied buying or taking nutritional supplements on her own. [52] On January 27, 2020, she was cleared of all charges. The substance was found in her results because of an exchange of bodily fluids with her boyfriend, who took LGD-4033.[53]

In January 2020, Chilean ATP tennis singles competitor Nicolás Jarry tested positive for both LGD-4033 and stanozolol. He protested at the time that the multi-vitamins from Brazil that he took on the advice of an unnamed doctor were contaminated.[54]

On 3 September 2022, sprinter Nzubechi Grace Nwokocha was provisionally suspended for the use of banned substances enobosarm and LGD-4033[55] by the Athletics Integrity Unit (AIU).

On 23 January 2024, Tristan Thompson was suspended for 25 games by the NBA for testing positive for ibutamoren and LGD-4033.[56]

On 12 March 2024, curler Briane Harris was provisionally suspended for up to four years after testing positive for LGD-4033. She denies this after being tested by doping control officers on Jan. 24 and notified of her positive test on Feb. 15. A second sample, called the B sample, also confirmed the positive test. She plans to appeal the ban to the Court of Arbitration for Sport, arguing she was unknowingly exposed to it through bodily contact. [57]

On 15 March 2014 cyclist Christos Volikakis was informed of an Adverse Analytical Finding on a re-analysis of a sample from the 2016 Rio Olympics. The athlete has since requested an analysis of the B sample.[58]

Research

Oral administration of LGD-4033 to cynomolgus monkeys at daily doses varying from 0 to 75 mg/kg over 13 weeks demonstrated significant body weight gain in both males and females. After 48 days, the 75 mg/kg dose testing was halted due to toxicity concerns, but this did not negatively impact development of the drug as this dose is significantly higher than the doses being utilized in a phase 2 clinical trial.[59]

Two

muscle strength in 76 healthy young men over 21 days.[2] It was generally well-tolerated in this study, with no significant adverse effects reported.[2]

A

muscle strength and was reported to be safe and well-tolerated.[6][7][8] Placebo-adjusted lean body mass was increased by 4.8% at 0.5 mg/day, 7.2% at 1 mg/day, and 9.1% at 2 mg/day after 12 weeks.[8]

As of 2023, LGD-4033 has been less studied than other SARMs like enobosarm, with only three small phase 1 clinical trials and one phase 2 trial, or a total of four clinical studies, having been conducted and reported.[14][11][9][2][8]

References

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    . LGD-4033 is a potent SARM that binds the human androgen receptor with Kd =0.9 nM. In animal models, it has anabolic effects on skeletal muscle and bone, but spares prostate, sebaceous glands, and female genitalia. In a double-blind, placebo-controlled, first-in-human Phase I trial, ascending single oral doses of LGD-4033 ranging from 0.1 mg to 22 mg were administered to healthy males. LGD4033 was safe and well tolerated up to the highest tested dose with no serious adverse events reported. LGD-4033 exhibited dose-proportional, sustained systemic exposure (AUC0-48hr: 24 to 7000 ng. hr/ mL for 0.1 and 22 mg doses, respectively). The elimination half-life (t1/2) was 31 hrs, indicating LGD-4033 is amenable for once daily dosing. PK-PD studies were conducted in orchiectomized (ORDX) rats, a model of androgen action, to determine the LGD-4033 efficacious exposure level. Subcutaneous minipumps were used to mimic the 10-fold longer t1/2 in humans vs. rats. A dose that produced an AUC of 80 ng. hr/mL restored the atrophied muscle mass of ORDX rats to the eugonadal level (270% increase in levator ani muscle weight with LGD-4033 vs. vehicle) and reduced the elevated luteinizing hormone level of ORDX rats by 98%. The efficacious range predicted by the preclinical model will be achieved by repeated daily doses ca. 0.25 mg in humans. Conclusion: LGD-4033 is a well-tolerated and highly tissue-specific, potential new treatment for sarcopenia (e.g., cancer cachexia or the frail elderly) and osteoporosis that is predicted to be effective using low, daily oral doses. A Phase I multi-dose study is in progress.
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    . Other molecules have been developed including LGD-4033 which increased muscle mass and strength in healthy males after 3 weeks (Basaria et al. 2013) [...] Recently, a phase 2 trial on the agent VK211 demonstrated dose-dependent increases in lean body mass, and improvements in physical performance in patients who had sustained hip fracture (Ristic et al. 2018). Whilst SARMs hold great promise as anabolic agents that may offer an effective therapy for osteosarcopenia, long-term side effects of these agents are unknown, studies are generally small and of short duration. Regulation of these products poses immense challenges with their high uptake on the black market and via the internet as performance-enhancing, body-building agents, which may overshadow their potential mainstream application in disorders of aging.
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    . Introduction Hip fractures are a leading cause of disability and morbidity in older people. Post-facture, an increased catabolic state often leads to loss of muscle, which can impair balance and endurance, potentially increasing the risk of further injury. Anabolic steroids have been shown to improve muscle mass in certain settings. Selective androgen receptor modulators (SARMs) could be similarly effective in older patients who have suffered muscle loss following hip fracture, while potentially avoiding undesired side effects associated with broad-acting anabolic agents. VK5211 is a novel, non-steroidal, orally available SARM that has been shown to improve muscle mass and bone mineral density in animal models. In humans, a prior Phase 1 study demonstrated increases in lean body mass after 21 days of dosing. Purpose A 12 week study was conducted to assess the safety and efficacy of VK5211 in patients who had suffered a hip fracture. Methods A randomized, double-blind, placebo-controlled, multicenter, international Phase 2 trial was conducted to evaluate VK5211 in patients recovering from hip fracture. Patients were randomized to receive daily oral VK5211 doses of 0.5 mg, 1.0 mg, 2.0 mg, or placebo, for 12 weeks. The primary endpoint evaluated change from baseline in lean body mass, less head, in patients receiving VK5211 compared with placebo. Secondary and exploratory endpoints included changes in appendicular lean mass, bone density, and functional performance. Results A total of 108 patients were randomized (83 F, 25 M; mean age 77). Patients receiving VK5211 demonstrated significant increases in lean body mass, less head, after 12 weeks. Placebo-adjusted increases were 4.8% at 0.5 mg, 7.2% at 1.0 mg, and 9.1% at 2.0 mg (p < 0.005 for each). The proportions of patients experiencing at least a 2.0 kg increase were 14% with placebo, 57% at 0.5 mg, 65% at 1.0 mg, and 81% at 2.0 mg (p < 0.01 for each). Patients receiving VK5211 demonstrated improvement in certain measures of functional performance, including the 6-minute walk test and short physical performance battery (these endpoints were not powered for significance). The rates of adverse events were similar in cohorts receiving VK5211 as compared with placebo, and no drug-related SAEs were observed in VK5211-treated patients. Conclusion VK5211 was well-tolerated and produced improvements in lean body mass in hip fracture patients following 12 weeks of dosing. Further evaluation in this setting is warranted.
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External links

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