Lily Jan
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Lily Yeh Jan | |
---|---|
Born | Yeh Kung-chu January 20, 1947 developmental neuroscience |
Spouse | Yuh Nung Jan |
Awards |
|
Scientific career | |
Fields | Neuroscience |
Institutions | University of California, San Francisco |
Doctoral advisor | Max Delbrück |
Lily Yeh Jan (Chinese: 葉公杼; pinyin: Yè Gōngzhù; Wade–Giles: Yeh Kung-chu;[1] born January 20, 1947) is a Taiwanese-American neuroscientist. She is the Jack and DeLoris Lange Professor of Physiology and Biophysics at the University of California, San Francisco, where she collaborates with her husband Yuh Nung Jan as co-PIs of the Jan Lab.[2]
Early life, education, and career
Lily Yeh was born Yeh Kung-chu (Ye Gongzhu) in
Jan attended
Lily Jan would go on to hold postdoctoral positions in the laboratory of Seymour Benzer at Caltech and subsequently in the laboratory of Stephen Kuffler at Harvard Medical School. Jan and her husband joined the faculty at University of California, San Francisco in 1979 where are leaders of a joint research group. She has been a HHMI investigator since 1984.[4]
Research
After graduating from
Jan and her husband joined the faculty as assistant professors at
The early years of the Jans' research group at UCSF was distinguished by their efforts on cloning the Shaker channel and studies of neural development. In the 1980s, their work on neural development was performed in collaboration with Alain Ghysen and Christine Dambly-Chaudiere. The Jans were tenured in 1983 and were selected as Howard Hughes Medical Institute Investigators in 1984. They have shared that from 1983 to 1986 their research goals were challenged by difficulties cloning the Shaker gene. In 1987, they were successful with cloning Shaker and enabling their team to perform functional studies on single potassium ion channels. Their neural development research has been particularly distinguished by breakthroughs in neurogenesis and cell fate specification (cut, numb, atonal, and daughterless).
Since 1994, the Jan lab has been organized in function and development subgroups led by each co-PI. The function group of the laboratory is led by Lily and largely focuses on the studies of ion channels, their assembly, and their dynamic response to neural activity.[9] The development subgroup led by Yuh Nung has been engaged with questions surrounding dendrite morphogenesis.[10]
Awards
- Vilcek Prize in Biomedical Science (2017)[11]
- Gruber Prize in Neuroscience (2012)[12]
- Wiley Prize in Biomedical Sciences(2011)
- Albert and Ellen Grass Lecture, Society for Neuroscience (2010)
- Edward M. Scolnick Prize in Neuroscience, Massachusetts Institute of Technology(2010)
- Ralph Gerard Prize, Society for Neuroscience (2009)
- Elected member, American Academy of Arts and Sciences (2007)
- Society of Chinese Bioscientists in America Presidential Award (2006)
- National Institute of Health MERIT Award(2006)
- Distinguished Alumni Award, California Institute of Technology (2006)
- K. S. Cole Award, Biophysical Society (2004)
- Stephen W. Kuffler Lecture, Harvard Medical School (1999)
- Harvey Lecture, New York (1998)
- Elected member, Academia Sinica, Taiwan (1998)
- Elected member, National Academy of Sciences (1995)[13]
- 38th Faculty Lecturer Award, University of California, San Francisco (1995)
- W. Alden Spencer Award and Lectureship, Columbia University (1988)
- Klingstein Fellowship Award (1983-1983)
- Alfred P. Sloan Research Fellowship (1977-1979)
Select publications
- Jan LY, Revel JP (August 1974). "Ultrastructural localization of rhodopsin in the vertebrate retina". The Journal of Cell Biology. 62 (2): 257–73. PMID 4139160.
- Jan LY, Jan YN (October 1976). "L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction". The Journal of Physiology. 262 (1): 215–36. PMID 186587.
- Jan LY, Jan YN (October 1976). "Properties of the larval neuromuscular junction in Drosophila melanogaster". The Journal of Physiology. 262 (1): 189–214. PMID 11339.
Personal and family life
In 1967, Lily Jan traveled to Shitou, Taiwan for a hiking trip to celebrate her college graduation. This trip resulted in her meeting
The Jans had their first child together a daughter, Emily Huan-Ching Jan, on August 6, 1977. Lily was still involved in research leading up to her due date and went into early stages of labor in the midst of the group meeting of her postdoctorate lab.[3] Just seven weeks later after celebrating the arrival of Emily, the Jans would move across the country to begin the next stages of their research careers at Harvard Medical School.
Just a few years later, the Jans had established their independent research group at
The Jans have shared that before their children went to college they rarely attended scientific meetings together such that there was always one parent at home with their children.[3] Outside of the lab, they have continued to enjoy their shared interests in hiking, exploration, and nature throughout their careers. And in 2011, after their visiting professorship at the Chinese Academy of the Sciences the Jans accomplished one of their lifelong goals, seeing Mt. Everest together from the base camp in Tibet.[3][12]
References
- ^ "葉公杼 Lily Yeh Jan" (in Chinese (Taiwan)). Academia Sinica. Retrieved 2018-02-08.
- ^ "Jan Lab-HHMI/UCSF". physio.ucsf.edu. Retrieved 2019-05-17.
- ^ a b c d e f g h i j "Jans' Autobiography and Lab History". UCSF. Retrieved 2018-02-08.
- ^ a b c "Archived copy". Archived from the original on 2016-07-23. Retrieved 2016-12-12.
{{cite web}}
: CS1 maint: archived copy as title (link) - PMID 28167753.
- PMID 4139160.
- PMID 186587.
- PMID 11339.
- ^ "Jan Lab-Function Group Research". physio.ucsf.edu. Retrieved 2019-05-17.
- ^ "Jan Lab-Development Group Research". physio.ucsf.edu. Retrieved 2019-05-17.
- ^ "The Vilcek Foundation - Lily & Yuh-Nung Jan - 2017 Vilcek Prize in Biomedical Science". www.vilcek.org. Retrieved 2019-05-17.
- ^ a b "Lily Jan". Gruber Foundation. Yale University. Retrieved 2019-05-17.
- ^ "Lily Jan". Nasonline.org. Retrieved 6 November 2018.