Magnetic resonance force microscopy
Magnetic resonance force microscopy (MRFM) is an imaging technique that acquires magnetic resonance images (
protein nuclear magnetic resonance spectroscopy. Detection of the magnetic spin of a single electron has been demonstrated using this technique. The sensitivity
of a current MRFM microscope is 10 billion times greater than a medical MRI used in hospitals.
Basic principle
The MRFM concept combines the ideas of
interferometer (laser beam) to create a series of 2-D images of the sample, which are combined to generate a 3-D image. The interferometer measures resonant frequency of the cantilever. Smaller ferromagnetic particles and softer cantilevers increase the signal-to-noise ratio
. Unlike the inductive coil approach, MRFM sensitivity scales favorably as device and sample dimensions are reduced.
Because the signal-to-noise ratio is inversely proportional to the sample size,
proteins
in situ.
Milestones
The basic principles of MRFM imaging and the theoretical possibility of this technology were first described in 1991.nanometer-scale in 2003.[3] Detection of the magnetic spin of a single electron was achieved in 2004.[4] In 2009 researchers at IBM and Stanford announced that they had achieved resolution of better than 10 nanometers, imaging tobacco mosaic virus particles on a nanometer-thick layer of adsorbed
hydrocarbons.[5]
References
- doi:10.1063/1.104757.
- doi:10.1063/1.110460.
- .
- S2CID 4346337.
- PMID 19139397.
External links
- University of Washington Quantum System Engineering and MRFM Home Page, https://web.archive.org/web/20060430032748/http://courses.washington.edu/goodall/MRFM/.
- Magnetic-Resonance Force Microscopy, http://www.medgadget.com/archives/2005/04/magneticresonan.html.
- Degen CL, Poggio M, Mamin HJ, Rettner CT, Rugar D (12 January 2009). "Nanoscale magnetic resonance imaging". PNAS. 106 (5): 1313–7. PMID 19139397.
- "Researchers Create Microscope With 100 Million Times Finer Resolution Than Current MRI". Phys.org. January 13, 2009.
- "IBM team boosts MRI resolution". BBC News. 13 January 2009. Retrieved 2009-01-14.
- Review Article: M. Poggio and C. L. Degen, Nanotechnology 21, 342001 (2010), Poggio, M.; Degen, C. L. (2010). "Force-detected nuclear magnetic resonance: recent advances and future challenges". Nanotechnology. 21 (34): 342001. S2CID 10028988.