Margaret Buckingham

Source: Wikipedia, the free encyclopedia.
Margaret Buckingham
ForMemRS
Born (1945-03-02) 2 March 1945 (age 79)
UK
Citizenshipdual French-British
Alma materLady Margaret Hall, Oxford[1]
Websitehttps://www.pasteur.fr/en/developmental-and-stem-cell-biology

Margaret Buckingham,

Centre national de la recherche scientifique (CNRS).[2] She is a member of the European Molecular Biology Organization, the Academia Europaea and the French Academy of Sciences
.

Biography

Margaret Buckingham was educated in

Centre national de la recherche scientifique (CNRS). She is a member of the scientific council of the ERC[3] and chairs the prize committee of the Lefoulon-Delalande Foundation for cardiovascular research. In 2013, she was awarded the gold medal of the CNRS.[4][5] She is a member of the French Academy of sciences,[6] a foreign/honorary member of the Royal Society of London/Edinburgh and a foreign associate of the National Academy of Sciences of the USA. She is also a member of EMBO and of the Academia Europaea.[7][circular reference
] She has French and British nationality, and is married to Richard Buckingham, Editor-in-Chief of Biochimie until December 2020, with three children.

Scientific research

Margaret Buckingham is a developmental biologist who is interested in how naïve multipotent cells acquire tissue specificity during

embryogenesis. She has studied both the formation of skeletal muscle and of the heart, using the tools of mouse molecular genetics to characterise cell behaviour and to identify the genes
that govern cell fate choices.

From pioneering research on the in vivo expression, structure and regulation of muscle genes,

Mrf4, cells fail to form skeletal muscle and acquire other mesodermal cell fates.[10] Characterisation of Myf5 enhancers revealed a direct role for Pax3 in their transcriptional activation at different sites of myogenesis.[11] From genetic screens, they identified other Pax3 targets, demonstrating the central role of Pax3 in the gene regulatory network that leads to the onset of myogenesis in the embryo.[12][13] They discovered a population of Pax3/Pax7-positive progenitors that are essential for foetal muscle development[14] and showed that Pax-positive satellite cells associated with adult fibres constitute stem cells for muscle regeneration.[15] They identified genes, including Pitx2/3, that affect the behaviour of these cells and showed that Myf5 mRNA, present in quiescent satellite cells is sequestered until these cells are activated after injury.[16]

Her main contribution to cardiogenesis is the identification of the second heart field (SHF) as a major source of cardiac progenitor cells that form specific regions of the heart.[17][18] The behaviour of these cells is controlled by gene regulatory networks and signalling pathways, exemplified by the FGF10 gene.[19] Retrospective clonal analysis complemented their work on the SHF and established a lineage tree for the myocardium, where the second lineage defines the SHF contribution whereas the first lineage contributes all the left ventricular myocardium.[20] This analysis revealed the clonal relationships between different sublineages that contribute to both cardiac muscle at the poles of the heart and anterior skeletal muscles[13][21] which are not under Pax3-control.[13][22] In addition to its conceptual importance for cardiogenesis, this work also has biomedical implications for congenital heart malformations.

Awards and honours

External links

Amsen, Eva (2011-01-25). "An interview with Margaret Buckingham: President of the French Society of Developmental Biology".

PMID 21266403
.

References

  1. ^ "Prominent alumni". Lady Margaret Hall, Oxford. Retrieved 30 November 2020.
  2. ^ "Developmental biologist Margaret Buckingham is awarded the 2013 CNRS Gold Medal". Consulate General of France in Vancouver. Retrieved 4 November 2013.
  3. ^ "ERC".
  4. ^ Communiqué de presse du CNRS publié le 18 septembre 2013.
  5. ^ "Article La Croix, Médaille d'or du CNRS". La Croix. 18 September 2013.
  6. ^ "Académie des sciences".
  7. ^ "Academia europaea".
  8. S2CID 28853102
    .
  9. S2CID 4335995
    .
  10. S2CID 4337095
    .
  11. PMID 16951257
    .
  12. PMID 20059958
    .
  13. ^
    PMID 28584083
    .
  14. S2CID 4415583
    .
  15. S2CID 39333234
    .
  16. PMID 22770245
    .
  17. PMID 11702954
    .
  18. S2CID 28455128
    .
  19. PMID 23093675
    .
  20. S2CID 25041610
    .
  21. PMID 20823066
    .
  22. S2CID 18747744
    .
  23. ^ "Professor Margaret Elizabeth Buckingham FRS, HonFRSE". The Royal Society of Edinburgh. Retrieved 9 February 2018.
  24. ^ ARTIFICA (18 September 2013). "Developmental biologist Margaret Buckingham is awarded the 2013 CNRS Gold Medal". CNRS (in French). Retrieved 3 November 2017.
  25. CNRS (1999). "Les quinze lauréats de la Médaille d'argent du CNRS 1999". cnrs.fr. Archived from the original
    on 22 February 2014. Retrieved 21 February 2014.
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