Nicholas Lydon
Nicholas Lydon | |
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Born | citation needed] | 27 February 1957 [
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Thesis | Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum (1982) |
Website | royalsociety |
Nicholas B. Lydon
Education
Lydon was educated at
Career
In 1982, Lydon accepted a position with Schering-Plough based in France as Chargé de Récherche.[3] Three years later, he moved to Switzerland to work with Ciba-Geigy Pharmaceuticals, with whom he developed Gleevec.[8] In 1997, he established Kinetex Pharmaceuticals in Boston which was acquired by Amgen in 2000, with whom he worked until 2002.[8] Thereafter, he established several companies that continue to develop drugs to treat various conditions.[8]
Honours and awards
- Warren Alpert Foundation Prize, 2000.[3]
- Twenty First Annual AACR-Bruce F. Cain Memorial Award, 2002.[3]
- Charles F. Kettering Prize, General Motors Cancer Research Foundation, 2002.[3]
- The
- The Japan Prize, with Brian Druker and Janet Rowley, 2012.[3]
- Fellow of the Royal Society, 2013.[10]
- Royal Society GlaxoSmithKline Prize and Lecture, 2014[11]
Lydon's nomination for the Royal Society reads:
Nick Lydon played a decisive role in the development of Gleevec (Imatinib), a drug that has saved the lives of thousands of patients with chronic myelogenous leukaemia (CML) and gastrointestinal stromal tumours (GIST). Gleevec revolutionised the field of cancer drug discovery by changing rapidly fatal diseases into easily treatable conditions, and showed that, by targeting an oncogene that is the molecular cause of a specific cancer, the defective cancer cells can be killed without any major side effects on normal cells. The remarkable efficacy of Gleevec profoundly changed the perception of protein kinases as therapeutic targets. From being considered to be virtually "undruggable" in 1994, they have become the pharmaceutical industry's most popular class of drug target today, accounting for over 50% of cancer drug discovery R&D. The international prizes that Nick Lydon has received include, most recently, the Lasker-DeBakey Clinical Medical Research Award from The Lasker Foundation.[10]
References
- ^ "Nicholas Lydon". www.scienceheroes.com. 2010. Retrieved 13 February 2013.
- ^ "Lasker – DeBakey Clinical Medical Research Award: Award Description". Lasker Foundation. Retrieved 16 August 2010.
- ^ a b c d e f g "Laureates of the Japan Prize". The Japan Prize Foundation. 2012. Retrieved 13 February 2013.
- PMID 11287972.
- Microsoft Academic
- S2CID 36102747.
- PMID 10991971.
- ^ a b c d e "Dr Nicholas Lydon". University of Dundee. 2011. Archived from the original on 17 May 2013. Retrieved 13 February 2013.
- ^ Lydon, Nicholas B. (1982). Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum (PhD thesis). University of Dundee.(subscription required)
- ^ a b "Dr Nicholas Lydon". Royal Society. 2013. Retrieved 29 May 2013.
- ^ "GlaxoSmithKline prize". Royal Society. Retrieved 12 September 2013.