Meiomitosis
In cell biology, Meiomitosis is an aberrant cellular division pathway that combines normal mitosis pathways with ectopically expressed meiotic machinery resulting in genomic instability.[1]
Description
Meiotic pathways are normally restricted to germ cells. Meiotic proteins drive double stranded DNA breaks, chiasma formation, sister chromatid adhesion and rearrange the spindle apparatus.[2]
During meiosis, there are 2 sets of cell divisions, the second division is similar to
Role in cancer
Meiotic proteins have been noted to be expressed in cancer particularly melanoma[3] and lymphoma. In cutaneous T-cell lymphoma meiosis proteins have been shown to be regulated with the cell cycle.[4] Lymphoma cell lines have also been noted to up-regulate meiosis specific genes with irradiation and a correlation with mitotic arrest and polyploidy has been noted.[5] The overall role of meiomitosis in cancer development and evolution has yet to be determined.
References
Sources
- Grichnik, JM (2008). "Melanoma, Nevogenesis, and Stem Cell Biology". Journal of Investigative Dermatology. 128 (10): 2365–80. PMID 18787546.
- Scott, L; Byrnes, D; Eller, M; Rosa, A; Escandon, J; Grichnik, J (2013). "Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability". Journal of Skin Cancer. 2013: 190109. PMID 23840955.